Use of antidepressants after colon cancer diagnosis and risk of recurrence.

Use of antidepressants after colon cancer diagnosis and risk of recurrence.

Psychooncology. 2019 Jan 31;:

Authors: Pocobelli G, Yu O, Ziebell RA, Aiello Bowles EJ, Fujii MM, Sterrett AT, Boggs JM, Chen L, Boudreau DM, Ritzwoller DP, Hubbard RA, Chubak J

Abstract
OBJECTIVES: Prior research examining the association between use of antidepressants after colon cancer diagnosis and risk of recurrence is scant. We evaluated this association among colon cancer patients diagnosed at two integrated health care delivery systems in the United States.
METHODS: We conducted a cohort study of stage I-IIIA colon cancer patients diagnosed at ≥18 years of age at Kaiser Permanente Colorado and Kaiser Permanente Washington during 1995-2014. We used pharmacy records to identify dispensings for antidepressants, and tumor registry records and patients' medical charts to identify cancer recurrences. Using Cox proportional hazards models, we estimated the adjusted hazard ratio (HR) of colon cancer recurrence comparing patients who used antidepressants after diagnosis to those who did not. We also evaluated the risk associated with use of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) separately.
RESULTS: Among the 1,923 eligible colon cancer patients, 807 (42%) used an antidepressant after diagnosis and 139 had a colon cancer recurrence during an average 5.6 years of follow-up. Use of antidepressants after colon cancer diagnosis was not associated with risk of recurrence (HR: 1.14, 95% confidence interval [CI]: 0.69-1.87). The HR for use of SSRIs was 1.22 (95% CI: 0.64-2.30) and for TCAs it was 1.18 (95% CI: 0.68-2.07).
CONCLUSIONS: Our findings suggest that use of antidepressants after colon cancer diagnosis was common and not associated with risk of recurrence. Future larger studies with greater power to examine risk associated with individual antidepressants would be valuable additions to the evidence base.

PMID: 30703275 [PubMed - as supplied by publisher]

from A via a.sfakia on Inoreader http://bit.ly/2HLdyyC