Αρχειοθήκη ιστολογίου

Παρασκευή 14 Δεκεμβρίου 2018

Explaining European Union effectiveness (goal achievement) in the Convention on Biological Diversity: the importance of diplomatic engagement

Abstract

Recent scholarly work on the European Union (EU) in international environmental agreements has thus far lacked a focus on explaining variation in EU performance/effectiveness in different negotiation processes within one agreement, especially when it comes to less prominent issue areas such as biodiversity. To fill that gap, this article seeks to explain the EU's effectiveness (goal achievement—GA) as a negotiator in the Convention on Biological Diversity (CBD) in three key negotiation processes: (1) the negotiations on the coming into being of the CBD (1990–1992); (2) the negotiations towards a Cartagena Protocol on biosafety (1995–2000); and (3) the negotiations towards a Nagoya Protocol on the access to and benefit-sharing of genetic resources (2004–2010). For each case, the article measures EU effectiveness/GA by comparing the EU's objectives for the international negotiations at the early stages of the process with the outcome of these negotiations. It tries to explain the degree of EU GA by considering EU diplomatic engagement and the EU's position in the constellation of all negotiating parties in terms of issue-specific bargaining power and interests. It highlights the EU's successful performance as a mediator and bridge builder in the negotiations on the Cartagena and Nagoya Protocols. This diplomatic engagement resulted in a high degree of EU GA as it was well adapted to the EU's position in the constellation of all negotiating parties in terms of bargaining power and interests. This article emphasises the need to adapt EU diplomatic engagement to this position to boost EU GA.



from Energy Ecology Environment Ambio via Terpsi Hori on Inoreader https://ift.tt/2S1MtaZ

Synergy potential between climate change mitigation and forest conservation policies in the Indonesian forest sector: implications for achieving multiple sustainable development objectives

Abstract

There has been growing interest in achieving multiple Sustainable Development Goals (SDGs) by identifying effective interactions or synergy potential among measures/policies on sustainable development. The simultaneous implementation of climate change mitigation (SDG 13) and forest protection (SDG 15) is an example of an interaction where the measures/policies that contribute to both goals can be identified and the overlaps eliminated. However, there are limited studies that quantitatively evaluate the synergy potential in the forest sector. This study is the first attempt to examine the synergy potential in the forest sector in Indonesia focusing on climate change mitigation and forest protection. We evaluated four scenarios that differentiated climate and forest policy options and assessed the effectiveness of implementing these two policies simultaneously by 2030, using a computable general equilibrium model and a land-use model. We found that the additional efforts needed for emission reduction were larger for the scenario not considering forest protection than for that considering forest protection. This caused differences in the mitigation measures introduced and the resulting land use that depended on the scenario. Consequently, mitigation costs would be reduced by implementing mitigation and forest protection policies simultaneously, suggesting that the synergy effect in the forest sector in Indonesia does exist. This also implies simultaneous contributions to SDGs 13 and 15 (Targets 13.2 and 15.2). To realize such synergies, which have not yet been considered, it is necessary for policymakers to fill the institutional gaps between the policies/strategies of mitigation and forest conservation and enforce the policies for SDGs.



from Energy Ecology Environment Ambio via Terpsi Hori on Inoreader https://ift.tt/2En8eOv

The effect of hyperosmolality application time on production, quality, and biopotency of monoclonal antibodies produced in CHO cell fed-batch and perfusion cultures

Abstract

Hyperosmolality has been commonly investigated due to its effects on the production and quality characteristics of monoclonal antibodies (mAbs) produced in CHO cell fed-batch cultures. However, the application of hyperosmolality at different times and its effect on biopotency have seldom been researched, especially in perfusion culture. In our study, different degrees of hyperosmolality induced by sodium chloride were investigated in anti-IgE rCHO cell fed-batch cultures and anti-CD52 rCHO cell perfusion cultures during the initial and stable phases. The results showed that the initial hyperosmolality group (IHG) in fed-batch and early phase of perfusion cultures exhibited significant suppression of the viable cell density yet an enhancement in specific productivity, whereas the stable hyperosmolality group (SHG) achieved higher mAb production in both fed-batch and perfusion cultures. Additionally, the SHG produced less aggregates and acidic charge variants than IHG in fed-batch culture, which differed from perfusion cultures. However, the contents of non-glycosylation heavy chain (NGHC) and man5 were higher in SHG than in IHG in fed-batch cultures at plus 60 and 120 mOsm/kg, which was similar to perfusion cultures. Furthermore, the biopotency in the IHG was higher than in the SHG at plus 60 and 120 mOsm/kg in fed-batch cultures, which is similar to complement-dependent cytotoxicity (CDC) efficacy in perfusion cultures. The biopotency of all group was acceptable, except FI3. Thus, the study shows that hyperosmolality at a certain level could be beneficial for both mAb production, quality and biopotency, which could play an important role in process development for commercial production.



from A via a.sfakia on Inoreader https://ift.tt/2UHPjDQ

Genome analysis and -omics approaches provide new insights into the biodegradation potential of Rhodococcus

Abstract

The past few years observed a breakthrough of genome sequences of bacteria of Rhodococcus genus with significant biodegradation abilities. Invaluable knowledge from genome data and their functional analysis can be applied to develop and design strategies for attenuating damages caused by hydrocarbon contamination. With the advent of high-throughput -omic technologies, it is currently possible to utilize the functional properties of diverse catabolic genes, analyze an entire system at the level of molecule (DNA, RNA, protein, and metabolite), simultaneously predict and construct catabolic degradation pathways. In this review, the genes involved in the biodegradation of hydrocarbons and several emerging plasticizer compounds in Rhodococcus strains are described in detail (aliphatic, aromatics, PAH, phthalate, polyethylene, and polyisoprene). The metabolic biodegradation networks predicted from omics-derived data along with the catabolic enzymes exploited in diverse biotechnological and bioremediation applications are characterized.



from A via a.sfakia on Inoreader https://ift.tt/2QW3y98

Relationship Between Health Literacy in Parents and Asthma Control in Their Children: A Prospective Study in a Diverse Suburban Population

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 4, Page 221-225, December 2018.


from A via a.sfakia on Inoreader https://ift.tt/2Cf1mkQ

Comparison of 3 Indices for Assessing the Severity of Bronchial Asthma Exacerbations in Children

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 4, Page 215-220, December 2018.


from A via a.sfakia on Inoreader https://ift.tt/2CfC6Lj

Direct Observed Therapy of Inhaled Corticosteroids for Asthma at School or Daycare

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 4, Page 226-229, December 2018.


from A via a.sfakia on Inoreader https://ift.tt/2Cd0MnA

Making the Case for Sesame: A Major U.S. Food Allergen

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 4, Page 241-242, December 2018.


from A via a.sfakia on Inoreader https://ift.tt/2Lgm7iV

Pediatric Spontaneous Pneumothorax: Our Experience and a Review of the Literature

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 4, Page 208-214, December 2018.


from A via a.sfakia on Inoreader https://ift.tt/2CdaYfM

Angiopoietin-1, Angiopoietin-2, and Periostin Levels in Children with Recurrent Wheeze

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 4, Page 230-235, December 2018.


from A via a.sfakia on Inoreader https://ift.tt/2Lijugt

Looking Towards the Future

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 4, Page 207-207, December 2018.


from A via a.sfakia on Inoreader https://ift.tt/2LklhS8

Role of the Airway Microbiome in Respiratory Infections and Asthma in Children

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 4, Page 236-240, December 2018.


from A via a.sfakia on Inoreader https://ift.tt/2Liha9p

Highlights from the U.S. Asthma Summit 2018

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 4, Page 243-244, December 2018.


from A via a.sfakia on Inoreader https://ift.tt/2LjaxDU

Assessment of oral mucosal conditions among beedi workers residing in beedi workers colonies in Karnataka, India

pae.gif

Padma K Bhat, Amit Kumar, CN Aruna, Bhumika Kamal Badiyani, MY Jayachandra

Journal of Oral and Maxillofacial Pathology 2018 22(3):298-302

Background and Objectives: Beedi workers are an important part of our society. Due to their occupation of beedi making, they face different types of health hazards. This study was undertaken to assess the oral mucosal conditions among beedi workers residing in beedi workers' colonies in Karnataka. Methodology: A cross-sectional study was carried out among 700 beedi workers in the age group of 18–60 years residing in five beedi workers' colonies in Karnataka. The information was recorded regarding personal history by personal interview by the investigator. The clinical examination was done using WHO 1997 "Oral Health Assessment Form." Significance is assessed at 5% level of significance. Results: It was found that 26.9% of study population had different oral mucosal lesions. Interpretation and Conclusion: The present study showed that oral mucosal conditions of beedi workers residing in beedi workers' colonies in Karnataka were relatively poor.

from A via a.sfakia on Inoreader https://ift.tt/2QSbFTZ

Physaliphorous cells

pae.gif

Deepak Pandiar, Smitha Thammaiah

Journal of Oral and Maxillofacial Pathology 2018 22(3):296-297



from A via a.sfakia on Inoreader https://ift.tt/2QT16Qt

Dr. Purshotam P. Nainani

pae.gif

Leela S Poonja

Journal of Oral and Maxillofacial Pathology 2018 22(3):292-292



from A via a.sfakia on Inoreader https://ift.tt/2QTAGhE

Evaluation of glutathione peroxidase in the blood and tumor tissue of oral squamous cell carcinoma patients

pae.gif

Kshipra Chandrakant Deshpande, Mina Milind Kulkarni, Dinesh V Rajput

Journal of Oral and Maxillofacial Pathology 2018 22(3):447-447

Aims and Objectives: The lowered antioxidant capacity and the oxidant–antioxidant imbalance have been considered to play a role in multistage carcinogenesis. The deleterious effects produced by reactive oxygen species depend on the imbalance between oxidant and antioxidant status in the body, so this study is aimed to evaluate the levels of antioxidant enzyme, glutathione peroxidase (GPx), in the blood and tumor tissues of oral squamous cell carcinoma (OSCC) patients in comparison with healthy controls. Materials and Methods: The study comprised of 38 participants divided into two groups. Group 1 comprised of 20 patients with OSCC and Group 2 comprised of age- and sex-matched 18 healthy individuals free of any habits and systemic illness. The levels of GPx were estimated in the blood and tissue samples in both groups by Paglia and Valentine method using a Commercial Biochemical assay kit (RANDOX), by ultraviolet-visible spectrophotometer. Results: The GPx levels were elevated in the whole blood and the tissue samples of OSCC cases as compared to the control group. It was also found that the GPx levels were increased in the tumor tissue with respect to the histopathological grading of the OSCC cases. Conclusion: Detection of antioxidant status may be useful to choose correct radiotherapy or chemotherapy, to monitor the effectiveness of the therapeutic strategy and to determine tumor resistance to therapy. Hence, the evaluation of GPx enzyme level can be used as a prognostic marker in patients with OSCC.

from A via a.sfakia on Inoreader https://ift.tt/2SRdZYU

Private practice of oral and maxillofacial pathology: A career option

pae.gif

Kabita Chatterjee

Journal of Oral and Maxillofacial Pathology 2018 22(3):290-291



from A via a.sfakia on Inoreader https://ift.tt/2QUMbWb

Experimental model of oral ulcer in mice: Comparing wound healing in three immunologically distinct animal lines

pae.gif

Paulo Goberlânio de Barros Silva, Érian Bezerra Belo de Codes, Milena Oliveira Freitas, Joyce Ohana de Lima Martins, Ana Paula Negreiros Nunes Alves, Fabrício Bitu Sousa

Journal of Oral and Maxillofacial Pathology 2018 22(3):444-444

Background: The oral wound healing is dependent of immune participation and the absence or augment of one specific immune profile can delayed wound healing. Objectives: So, the objective of this study was t evaluate the wound healing of oral traumatic ulcer (OTU) in cheek mucosa of swiss, balb/c and c57bl6J mice. Materials and Methods: A total of 144 mice (25-30g) were distributed in three groups: swiss (n = 48), balb/c (n = 48) and c57bl/6j (n = 48). An OTU was performed using a dermatological punch in left cheek mucosa. The animals were euthanized daily (n = 6/group/day by 8 days) for evaluation of the ulcer area, weight loss and histological analysis. Results: There are no differences between ulcer area in three groups; however only swiss group showed total wound healing. Swiss group showed weight loss in 2nd and 3rd days recovering the body mass in 4th day (P < 0.01). Balb/c group showed the greater weight loss (P < 0.05) and c57bl/6j did not show body mass variation (P = 0.258). Histologically swiss group was the only group that showed total reepithelization (P < 0.001). Balb/c (P = 0.022) and c57bl/6j (P < 0.001) showed decrease in histological scores, chronic inflammation on the 8th day. Actinomyces was significantly more observed in surface of OTU of balb/c. Conclusion: Balb/c mice showed high infection of OTU surface delaying wound healing, and greater weight loss. C57bl/6J mice showed low infection of OTU, but not healing along the eight days. Only the Swiss mice showed wound healing of OTU.

from A via a.sfakia on Inoreader https://ift.tt/2SMwvBu

The importance of ctokeratins in the early detection of oral squamous cell carcinoma

pae.gif

Aiman A Ali, Badr A Al-Jandan, CS Suresh

Journal of Oral and Maxillofacial Pathology 2018 22(3):441-441

Background: Oral cancer is usually diagnosed at advanced stages. The pattern of keratin expression in normal epithelia and the change in their expression in premalignant lesions and carcinomas have suggested the possibilities of improving diagnosis. The aim of this study is to determine the use of acidic cytokeratins (CKs) as biomarkers of histopathological progression in oral carcinogenesis. Materials and Methods: A total of 50 paraffin blocks of histological specimens diagnosed as hyperplastic epithelium, dysplastic epithelium, well-differentiated squamous cell carcinoma (SCC) and poorly-differentiated SCC (10 specimens each) were included in this study, in addition to 10 normal oral mucosal samples. All samples were stained immunohistochemically with CKs (10-ab1, 14, 16-ab1, 18-dc10 and 19-abs10) using Ventana Medical Systems (Arizona-USA). The expression of CKs antigen was evaluated as absent, mild, moderate and severe. Results: CK10-ab1 was found to be positive in the suprabasal layers of all specimens in normal and hyperplastic epithelium, while it was moderate in dysplastic epithelium and mild in well-differentiated SCC. CK10-ab1 was negative in all samples with poorly-differentiated SCC (P < 0.005). CK14 was positive in all specimens of all groups whereas CK16-ab1 was negative in all specimens of all groups. The stain of CKs 18-dc10 and 19-abs10 was restricted to the basal cells only in normal, hyperplastic and dysplastic epithelium, while it was mild in well-differentiated and poorly-differentiated SCC (P < 0.01). Conclusion: CK10-ab1 disappeared gradually with the progression of malignant changes of squamous cells whereas CKs 18-dc10 and 19-abs10 increased gradually at the same time. Such changes in the protein mapping of squamous cells need more investigation for a better understanding of oral SCC.

from A via a.sfakia on Inoreader https://ift.tt/2SJKl7I

A rare case report of craniofacial fibrous dysplasia

pae.gif

Vidyadevi Chandavarkar, Pavan Manohar Patil, Deepak Bhargava, Mithilesh N Mishra

Journal of Oral and Maxillofacial Pathology 2018 22(3):406-409

Fibrous dysplasia (FD) is a fibro-osseous lesion of the osseous structures of the body. The exact cause is unknown; however, recently, the cause has been reported to be postzygomatic somatic mutation in guanine nucleotide-binding protein, alpha stimulating 1 gene located at chromosome 20q13.2. The three subtypes of FD are monostotic, polyostotic and craniofacial. The term craniofacial FD (CFD) is used to describe FD where the lesions are confined to contiguous bones of the craniofacial skeleton. This report describes the case of CFD of a 20-year-old male patient who had unusual presentation involving right maxilla and frontal bone of the left side of the face. The clinical features, radiological findings and treatment have been discussed.

from A via a.sfakia on Inoreader https://ift.tt/2SSJnq1

Microarray-based gene expression profiling for early detection of oral squamous cell carcinoma

pae.gif

Shwetha Hulimavu Ramaswamyreddy, T Smitha

Journal of Oral and Maxillofacial Pathology 2018 22(3):293-295



from A via a.sfakia on Inoreader https://ift.tt/2QSyiYp

The cusp of Carabelli: Frequency, distribution and type in the Bengaluru population

pae.gif

T Smitha, Deepak Venkatesh, M Veeresh, KN Hema, HS Sheethal, MA Vidya

Journal of Oral and Maxillofacial Pathology 2018 22(3):418-422

Aims: Detailed description and study of teeth traits could provide valuable information regarding phylogeny of man and distinctions between races and subraces. But morphological variations of the human dentition have not been utilized to their full potential by anthropologists concerned with patterns of human biological variation in Indian population. The aim of the present study is to detect the frequency and degree of expression of Carabelli's trait in Bengaluru population, this helps to develop a probabilistic model to distinguish individuals from specific human populations, particularly for forensic purposes. Materials and Methods: A total number 400of age and sex matched individuals from four different ethnic groups – Hindu, Islam, Christian and Iranians were examined clinically and study casts were made. Permanent maxillary first molars were examined for the expression of Carabelli's trait, Dahlberg classification system was used to score the trait on the teeth. The scores were recorded on Osteoware Dental Morphology software. The cast were examined by 2 observers independently to eliminate intra observer variation in interpretation and mean of 2 was taken for analysis. The data so obtained was statistically analysed especially emphasizing on differences between above mentioned 4 ethnic groups. Results: Cusp of Carabelli was present in 87% of the study population in maxillary first permanent molar. Type 3 was the most frequently expressed and Type 6 was the least frequently expressed and both type being expressed in Islamic groups. The expression of trait was bilateral in 90% of the surveyed groups. Conclusions: It was concluded that the prevalence of cusp of Carabelli in the small population from Bengaluru considered in the present study was found to possess a high degree of Carabelli trait expression.

from A via a.sfakia on Inoreader https://ift.tt/2SP4BEV

Evaluation of canine sexual dimorphism in deciduous and permanent dentition

pae.gif

Pramod Ingaleshwar, Vina Vaswani, Satish Subrao Bhosale, V Deepak, Pramod Redder, T Smitha

Journal of Oral and Maxillofacial Pathology 2018 22(3):450-450

Introduction: Teeth are an excellent material in living and nonliving populations for anthropological, genetic, odontologic and forensic investigations. Among the various calcified structures in the human body, teeth have gained lot of popularity in estimating the sex of an individual as they are highly resistant to destruction and decomposition. The present study aims to assess the importance of canines in sexual dimorphism in both primary and permanent dentition as well as to describe the dimensional characteristics of canines among the population of Bagalkot district of Karnataka, India. Materials and Methods: One hundred and fifty participants belonging to Bagalkot district of Karnataka population, 100 adults (50 males and 50 females) in the age group of 17–30 years and 50 children (25 boys and 25 girls) in the age group of 3–6 years were included in the study. Impressions were made using alginate and study models were prepared using dental stone. Clinical crown height (CCH), maximum mesiodistal diameter (MMD) and maximum buccolingual width (MBL) of maxillary and mandibular canines of both dentitions were measured using digital vernier caliper. Results: In deciduous dentition, significant differences were noted between maxillary and mandibular deciduous canines in male and female children using three dimensions, except mandibular canine, i.e., CCH did not show a significant difference. In permanent dentition, CCH and MMD showed significant differences except mandibular canines not showing significant differences in MBL (P < 0.05). Conclusion: Thus, canines can act as a valuable tool in gender determination as there is significant sexual dimorphism in maxillary and mandibular deciduous and permanent dentition.

from A via a.sfakia on Inoreader https://ift.tt/2SPv1qe

Estimation of serum hepcidin in oral submucous fibrosis before and after supplementation with oral iron: A randomized control clinical trial

pae.gif

Tejavathi Nagaraj, HN Santosh

Journal of Oral and Maxillofacial Pathology 2018 22(3):303-306

Background: Iron-deficiency anemia is synonymous with oral submucous fibrosis (OSMF). The cause for the same has not been ascertained yet. OSMF by way of anemia of chronic disease could be a probable cause of iron deficiency. Aim and Objective: This study was intended to evaluate the level of hemoglobin (Hb) in OSMF and to establish a relationship between serum hepcidin and Hb with OSMF, before and after oral supplementation of iron. Materials and Methods: The clinical trial was registered with the Clinical Trial Registry of India (CTRI/2016/03/006761). Eighty participants were selected. Based on the hematocrit values, they were divided into equal number of case (Group I) and control (Group II). Serum hepcidin was evaluated in these eighty participants with clinically established OSMF. Participants in the case group with low hematocrit values indicative of iron-deficiency anemia were supplemented with oral iron capsules twice daily for 3 months. After an interval of 3 months, serum hepcidin and hematocrit were evaluated. Statistics: Statistical analysis was done using SPSS software version 11.5 (IBM, New York, USA). One-way ANOVA test was done to assess the correlation between Hb% and serum hepcidin. Unpaired t-test was done to correlate Hb% and hepcidin before and after oral supplementation of iron. Clinical significance was established by calculating the effect size. Results: There was a significant correlation between the values of serum hepcidin and Hb (P < 0.001) before and after oral supplementation of elemental iron. After oral supplementation of iron, hematocrit improved in Group I along with reduction in serum hepcidin. Conclusion: It can be concluded that reduction of serum hepcidin is indicative of improvement in iron stores of body. Hence, serum hepcidin can be utilized as a diagnostic marker to assess iron stores in OSMF.

from A via a.sfakia on Inoreader https://ift.tt/2QT15vT

Prevalence of oral potentially malignant disorders and oral malignant lesions: A population-based study in a municipal town of southern Kerala

pae.gif

TT Sivakumar, Nisha Sam, Anna P Joseph

Journal of Oral and Maxillofacial Pathology 2018 22(3):413-414

Oral cancer burden poses a major challenge in India. Oral cancer in the majority of instances arises from preexisting oral potentially malignant disorders (OPMDs). Early detection of OPMD and elimination of primary risk factors such as smokeless and smoking tobacco help in reduction of oral cancer. A study was conducted to find the prevalence and associated risk factors of OPMDs and oral malignant lesions (OMLs) in Punalur township of South Kerala. A total of 2368 patients were screened, out of which 156 were identified with OPMD and 5 with OML. A male predominance was noted for both OPMD and OML. Strong association with smokeless tobacco and smoking tobacco habits was seen with patients having OPMD and OML.

from A via a.sfakia on Inoreader https://ift.tt/2SOq7tz

Detection of human papilloma virus-E6/E7 proteins of high-risk human papilloma virus in saliva and lesional tissue of oral squamous cell carcinoma patients using nested multiplex polymerase chain reaction: A comparative study

pae.gif

Rajbir Kaur Grewal, Keya Sircar, Kishore G Bhat, Dilpreet Singh Grewal, Krishan Kumar Tyagi, Simon David

Journal of Oral and Maxillofacial Pathology 2018 22(3):318-324

Introduction: Human papilloma virus (HPV)-associated oral squamous cell carcinoma (OSCC) shows different biological behavior as compared to tobacco-induced OSCC. Mere presence of HPV in OSCC is of no clinical significance; however, the integration of HPV-DNA through E6/E7 gene into the host genome is important as it affects the development and progression of OSCC. Aim: The aim of this study was to determine the presence of E6/E7 proteins of high-risk (HR) HPV (HPV16 and HPV18) in saliva as well as lesional tissue of OSCC patients and to determine the use of saliva as an alternative to tissue for E6 and E7 proteins in OSCC. Materials and Methods: Histopathologically confirmed 47 cases of OSCC were taken up for the study. The tumor tissue and saliva sample of each patient were obtained to detect the presence of HPV16 and HPV18 along with E6/E7 proteins in both samples by nested multiplex polymerase chain reaction (NMPCR). The data were analyzed using Student t-test (2 tailed) and Wilcoxon signed-ranks test. Results: In tumor tissue, 40.42% of cases showed HPV16 (19/47) positivity while 34.04% were HPV18 (16/47) positive; whereas, in salivary sample, 31.91% showed HPV16 (15/47) positivity while 25.53% of cases were HPV18 positive (12/47). Mean age of participants was 46.7 years, males showed no significant difference from females in the prevalence of HPV 16/18 with tongue being the most common site for the occurrence. There was no statistically significant difference for HPV16/18 presence in tissue and saliva sample of OSCC. Taking lesional tissue sample as standard, sensitivity and specificity for HPV16 and HPV18 in saliva by NMPCR was estimated at 68.42% and 92.86%, respectively. The accuracy level of NMPCR detection for HPV16 was 82.98% and HPV18 was 65.96%. Conclusion: The study revealed no significant difference in the prevalence of HPV (16/18) among tissue and saliva of OSCC patients in Indian population. The study also found no difference in the level of DNA content of HPV in saliva and tissue indicating that saliva can be used as an alternative predictor of HPV positivity in OSCC.

from A via a.sfakia on Inoreader https://ift.tt/2QSwCyh

Bcl-2 and c-Myc expression in oral dysplasia and oral squamous cell carcinoma: An immunohistochemical study to assess tumor progression

pae.gif

N Pallavi, Govind Raj K Nalabolu, Santhosh Kumar S Hiremath

Journal of Oral and Maxillofacial Pathology 2018 22(3):325-331

Introduction: Oral cancer is a multistep process involving foul play of proto-oncogenes that induce cell proliferation, inactivation of tumor suppressor gene and cessation of programmed cell death. Among various proto-oncogenes, the nature and behavior of Bcl-2 and c-Myc in oral precancerous/cancerous lesions were obscured which require further assessment for better understanding of etiology, treatment and prognosis. Aim: The aim of the study is to assess the expression of Bcl-2 and c-Myc in oral epithelial dysplasia and oral squamous cell carcinoma (OSCC). Materials and Methods: This retrospective study of 70 (oral dysplasia [30], OSCC [30] and normal gingiva [10]) is immunohistochemically assessed for Bcl-2 and c-Myc for distribution, intensity, percentage of positive cells, localization and immunoreactive scores using ImageJ software. Results: Bcl-2 showed 60% and 37% positivity within dysplasia and OSCC, respectively (P = 0.03); c-Myc showed 87% and 90% positivity within dysplasia and OSCC, respectively. In OSCC, c-Myc showed moderate intensity (P = 0.04). Average percentage of positive cells expressing c-Myc and Bcl-2 increased proportionally within grades of dysplasia (P = 0.000 and P = 0.008, respectively), whereas in OSCC, only c-Myc showed significant expression (P = 0.021). Localization of c-Myc was seen in the nucleus among OSCC (P = 0.01). c-Myc and Bcl-2 showed moderate immunoreactivity in dysplasia (P = 0.005 and P = 0.013, respectively), whereas in OSCC, moderate immunoreactivity of c-Myc (P = 0.05) was observed. Conclusion: Variable expression of c-Myc and Bcl-2 reveals that these proteins act in synergism in early phases of carcinogenesis, whereas in later stages, due to the diminished activity of Bcl-2, c-Myc interacts incoordination with other oncogenes contributing to tumor progression.

from A via a.sfakia on Inoreader https://ift.tt/2QSs62I

Dentition status and treatment needs and its correlation with oral health-related quality of life among men having sex with men and transgenders in Pune city: A cross-sectional study

pae.gif

Shrikanth Muralidharan, Arunkumar Acharya, Ajit V Koshy, Judy Annie Koshy, TL Yogesh, Bindumadhav Khire

Journal of Oral and Maxillofacial Pathology 2018 22(3):443-443

Introduction: Dental diseases are universal in nature. Their presence and severity may vary from one individual to another and is also affected by multiple factors such as gender, knowledge, attitude and the affordability of dental/oral care. Gay, bisexual and transgender community is one among the socially disadvantaged community in our country. The present study was carried out in the city of Pune, India, to evaluate the prevalence of dentition status and the treatment needs among the men who have sex with men (MSMs) and transgenders (TGs) and its correlation with the oral health-related quality of life. Materials and Methods: The sample size was 270. Convenience sampling was followed. The WHO oral health assessment for 1997 was used to record dentition status and treatment needs. Oral Health Impact Profile-14 was used to record the oral health-related quality of life. SPSS 22.0 (Chicago, IL, USA) was used for statistical analysis. All P < 0.05 were considered to be statistically significant. Results: There was no statistically significant difference seen across the various domains in the overall impact of the oral quality of life. There was a significant correlation between the decayed teeth, missing teeth and overall decayed, missing and filled teeth scores with respect to the seven domains. Problems arising due to past dental experience (dental caries), lost natural tooth structures replaced with restorative material and a cumulative impact significantly affected the outcome of the oral health-related quality of life of the participants. Conclusion: There was an alteration in quality of life of the MSMs and TGS with respect to dental caries. This calls for an intervention that is tailor-made to meet the needs of this group.

from A via a.sfakia on Inoreader https://ift.tt/2SUzHeH

Detection of salivary heat shock protein 27 by enzyme-linked immunosorbent assay and its correlation with histopathology of oral leukoplakia

pae.gif

V Soumya Bhavana, MG Madhura, B Veerendra Kumar, S Suma, Y Sarita

Journal of Oral and Maxillofacial Pathology 2018 22(3):307-313

Context: Salivary analytes may be used as biomarkers for translational and clinical applications. Heat shock proteins (Hsps) are ubiquitous, highly conserved proteins found in all prokaryotic and eukaryotic species. Hsp27, a low molecular weight protein, may act as a salivary biomarker. Leukoplakia is the most common oral potentially malignant disorder and various salivary biomarkers such as interleukin-6, 8, tumor necrosis factor-α and MMPs have been detected in it. Oral leukoplakia presents clinically as homogenous and nonhomogenous forms; the microscopic pattern ranges from simple epithelial hyperplasia to carcinoma in situ. Aims: This study aims to detect salivary Hsp27 in oral leukoplakia by enzyme-linked immunosorbent assay (ELISA) and to correlate its expression pattern with histopathology. Materials and Methods: A total of 45 cases had constituted the study group. Salivary Hsp27 levels were assessed by ELISA in histopathologically confirmed cases of oral leukoplakia and were compared with that of healthy volunteers. Statistical Analysis: Mann–Whitney U-test and Spearman's correlation coefficient were used for the detection of Hsp27 and its correlation with mean absorbance levels. Results: The mean absorbance values had shown elevated expression of Hsp27 in oral leukoplakia when compared to that in healthy volunteers. Conclusions: The present study had shown elevated expression of salivary Hsp27 in oral leukoplakia which could be attributed to altered redox potential.

from A via a.sfakia on Inoreader https://ift.tt/2QVXttd

Assessment of palatal rugae pattern and its significance in orthodontics and forensic odontology

pae.gif

AM Shailaja, IR Umme Romana, Goutham Narayanappa, T Smitha, Nishitha C Gowda, HK Vedavathi

Journal of Oral and Maxillofacial Pathology 2018 22(3):430-435

Background: Palatal rugae are nonidentical mucosal elevations seen on anterior third of palate. They are arranged in transverse direction on either side of the mid-palatine raphe. Although they are the most stable anatomical structures in the oral cavity, certain conditions such as expansion in orthodontic treatment contribute to some amount of variations in their pattern qualitatively. The aim of this study was to compare the shape of rugae and its positional changes before and after rapid maxillary expansion. Materials and Methods: Fifteen pairs of pre- and post-maxillary expansion casts showing finer details of palatal rugae from seven males to eight females in the age group of 10 ± 2.5 years were selected for this study with transverse maxillary deficiency reporting to Department of Orthodontics, VS Dental College and Hospital. The shape of rugae and the distance between the median points and lateral points of the first and the last two rugae on either side of the mid-palatal raphe were noted and marked. The data collected was statistically analyzed using SPSS program. Results: There was statistically significant difference in the distance between medial and lateral points of first two and last two rugae. Conclusion: During maxillary expansion, there is stability of palatal rugae with respect to its shape, number but not with respect to its position. Clinically, the orthodontist can quantify the palatal separation after expansion of the maxillary arch using the interruga distance.

from A via a.sfakia on Inoreader https://ift.tt/2SJo9dO

Stress recognition in dental students using smartphone sensor and a software: A pilot study

pae.gif

Santosh Hunasgi, Anila Koneru, Amrutha Rudraraju, Vardendra Manvikar, M Vanishree

Journal of Oral and Maxillofacial Pathology 2018 22(3):314-317

Aims and Objectives: A dental student in his/her life goes through several academic stresses. Mild stress may be beneficial in cognitive tasks and performance, while persistently high stress may lead to anxiety and depression. Thus, the aim is to compare the stress levels in students appearing for previva and postviva during university examinations. Materials and Methods: The study was carried out on 70 3rd year Bachelor of Dental Surgery students who were appearing for their university practical examination. Heart rate, oxygen saturation and stress levels were measured using Android S-HEALTH software. The data were compared and tabulated. Results obtained were statistically analyzed using paired "t"-test. Results: Heart rate, oxygen saturation and stress levels were statistically high in previva of all the students. Conclusion: It can be concluded that examination is a situational stress resulting in anxiety due to increased levels of plasma cortisol reflected by an increased heart rate, oxygen saturation and stress levels. It is important for students to use stress-reducing measures or to reduce them as much as possible to avoid factors that can affect themselves and their patients in stressful way.

from A via a.sfakia on Inoreader https://ift.tt/2QVSVmK

Study of salivary arecoline in areca nut chewers

pae.gif

Deepak Venkatesh, RS Puranik, SS Vanaki, Surekha R Puranik

Journal of Oral and Maxillofacial Pathology 2018 22(3):446-446

Aims: Arecoline, a predominant alkaloid present in arecanut, has been implicated in the pathogenesis of several oral diseases because of its mutagenic and carcinogenic potential. The response of cultured cells to arecoline is highly dependent on its concentration; arecoline stimulates cultured cells above 0.1 μg/ml and is cytotoxic above 10 μg/ ml. Although this alkaloid seems important for areca nut induced oral diseases and carcinogenesis, little is known of the levels achieved before, during and after chewing. Also, it is prudent to understand its effects in arecanut chewers for a comprehensive understanding of its pathogenesis. Accordingly, the present study quantified the salivary arecoline levels in arecanut chewers. Materials and Methods: The study participants were divided into Study Group A & B and Control Group C; unstimulated whole saliva was collected by spitting method for a period of 5 min. Then, participants in Group A and C chewed 0.5 g of areca nut without any other additives while in Group B were asked to chew 0.5 g of inert rubber base impression material. Stimulated whole saliva from all three groups was collected into graduated tubes during chewing at time intervals of 1, 3, 5, 10, 15, 20 and 25 min. Then, all participants were asked to remove nut particles or inert rubber base material from the mouth, and saliva samples were collected further up to 20 min, changing tubes at 5 min interval. Salivary arecoline was quantitated by HPLC-MS. The tabulation and descriptive statistics of the study were carried out. Results: In the present study, baseline levels of arecoline were zero in all three groups, whereas mean salivary arecoline levels during chewing were 76.93 ng/ml, 129.83 ng/ml and 64.83 ng/ml and after chewing were 196.17 ng/ml, 321.12 ng/ml and 43.75 ng/ml in Groups A, B and Control respectively, which were significantly higher than reported threshold levels. Conclusions: The data from this study reveals that a significant amount of arecoline would be trapped in oral cavity, or being re-circulated between blood and saliva might have resulted in surprisingly high levels of arecoline even 10 mins after chewing in both groups after which the levels started declining. The higher levels of salivary arecoline achieved during and after chewing are enough to cause cytotoxic and genotoxic effects on oral tissues over a period of time in chronic chewers. The great differences in salivary arecoline levels achieved during chewing, may contribute to the variable response to areca nut seen in communities where this habit is widespread. Areca nut users have persistent background salivary arecoline levels long after chewing, whereas concentrations achieved are highly variable and consistent with a role in oral pre-malignancy and malignancy..

from A via a.sfakia on Inoreader https://ift.tt/2SSd6iN

miR-487b mitigates allergic rhinitis through inhibition of the IL-33/ST2 signaling pathway

OBJECTIVE: To investigate the potential effect of miR-487b/IL-33-ST2 axis on the pathology of allergic rhinitis (AR) and the relevant mechanism.

PATIENTS AND METHODS: The expression level of interleukin-33 (IL-33), a homolog of sulfotransferase (ST2), and miR-487b were detected in patients with or without allergic rhinitis. Luciferase assay was performed to evaluate the interaction between miR-487b and IL-33, and the effects of miR-487b/IL-33-ST2 axis on allergic rhinitis mice were determined by established allergic rhinitis model in mice by ovalbumin (OVA). The levels of OVA-specific immunoglobulin E (Ig-E), proinflammatory cytokines (IL-4, IL-5, and IL-13), and pathological alterations were detected.

RESULTS: The level of IL-33 and its specific ligand ST2 were found increased in allergic rhinitis patients while miR-487b expression level was markedly repressed. To confirm whether miR-487b has a regulation effect on IL-33, we checked it in three publicly available algorithms, TargetScan, miRDB, and microRNA. We found that IL-33 is a direct target of miR-487b, and Luciferase assays confirmed our hypothesis, the subsequent experiments showed that up-regulation of miR-487b could inhibit expression of IL-33 and ST2, resulting in the decrease of the immunoglobulin E (Ig-E), proinflammatory cytokines and mitigation of pathological alterations.

CONCLUSIONS: Our research discovered the suppressor function of miR-487b in allergic rhinitis and revealed that miR-487b/IL-33-ST2 axis may be a potential therapeutic target for the treatment of allergic rhinitis.

L'articolo miR-487b mitigates allergic rhinitis through inhibition of the IL-33/ST2 signaling pathway sembra essere il primo su European Review.



from A via a.sfakia on Inoreader https://ift.tt/2GdI6bt

Impacts of Shallow Lake Restoration on Vegetation and Breeding Birds in Iowa

Abstract

The Shallow Lakes Restoration Project aims to restore eutrophic shallow lakes throughout the Iowa Prairie Pothole Region (PPR). We compared the vegetation taxa richness and frequency of taxa in three vegetation groups surveyed in 2016 and 2017 across non-restored sites, younger restorations, and older restorations. We also assessed the impact of these groups on numbers of breeding marsh birds. Restored wetlands had between 2.7 (95% CI 2.3, 3.2) and 4.7 (95% CI 3.9, 5.5) more species than non-restored sites among the three vegetation groups. Typha sp. was the most abundant emergent species. Lemna minor and Ceratophyllum demersum were the most abundant floating-leaved and submersed species, respectively. The frequency of submersed aquatic vegetation increased with years since restoration, while floating-leaved vegetation and Typha sp. peaked at 7 years post-restoration. The frequency of Typha sp. positively influenced Marsh Wrens and Yellow-headed Blackbirds. Water depth negatively affected Marsh Wrens, but water depth positively influenced Yellow-headed Blackbirds. Floating-leaved vegetation positively affected Virginia Rails, while water depth had a negative effect on this species. Our results indicate that after about 7 years further management of the vegetation and water levels may need to occur and should include maintaining appropriate conditions for breeding marsh birds.



from Energy Ecology Environment Ambio via Terpsi Hori on Inoreader https://ift.tt/2QuCBdc

Comparable investigation of polyaniline behavior towards gaseous ammonia and toluene adsorption

Abstract

With raising awareness of gaseous air pollutants and their harmful impact, adsorption is considered one of the most prominent techniques for gaseous emissions control. The usage of polyaniline as a gas adsorbent is an innovative idea. This work aims to compare the efficacy of synthesized polyaniline nanotubes (PANT) as a novel adsorbent towards inorganic gases (ammonia NH3) and volatile organic compounds (toluene vapor). PANT was prepared via a sol-gel preparation technique. The molecular structure of prepared PANT was characterized by Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The morphological structure was confirmed using transmission electron microscopy (TEM) and scanning electron microscope (SEM). The PANT adsorbent surface area was determined using Brunner Emmett Teller (BET). Dynamic behavior of simulated feed gas mixture of NH3 and toluene in air were examined using a fixed bed adsorption arrangement. The same adsorption conditions (inlet concentration, gas mixture feed flow rate, and a fixed amount of adsorbent) were applied for both NH3 and toluene adsorption test. The NH3 and toluene removal efficiencies were 100% and 96% respectively. Consequently, PANT is an auspicious adsorbent that can be utilized to control the indoor and outdoor gaseous air emissions.

Graphical Abstracts



from Energy Ecology Environment Ambio via Terpsi Hori on Inoreader https://ift.tt/2CetKDu

Concept Device Designed to Tame Menopausal Hot Flashes

According to the Study of Women's Health Across the Nation (SWAN), up to 80% of women experience vasomotor menopausal symptoms, including hot flashes and night sweats, when transitioning into and through menopause. Most of the women studied rated their symptoms as moderate to severe--significantly affecting quality of life. In fact, vasomotor symptoms are one of the chief menopause-related problems for which women in the United States seek medical treatment. To explore what women in menopa...

from A via a.sfakia on Inoreader https://ift.tt/2BgtySG

Meet the Post-Op Bra That's Long Overdue

Efrat Roman was diagnosed with breast cancer a little more than a decade ago and underwent a total of five different surgeries due to complications. As if going through multiple breast operations weren't challenging enough, Roman was surprised to find out that the post-op breast dressing options were severely lacking. "I realized there wasn't anything designated for the dressing of breasts post-op," Roman told MD+DI. "There are reusable bras that are post-op bras, but the fact that they ar...

from A via a.sfakia on Inoreader https://ift.tt/2BjaCCY

Drying Cabinets with Sliding Doors for Low Material Volumes

It is possible to position this range on a bench or mount on a wall. The range is also available in a variety of finishes. Capacities: 100 and 180 L Standard Features Bench or wall mounted Choice of stainless steel or epoxy-coated finish Temperature up to 85 °C Over-temperature protection Adjustable shelf position

from A via a.sfakia on Inoreader https://ift.tt/2UJGYzo

What is volumetric 3D printing and why it could mean the end of additive manufacturing

Progress moves fast in the 3D printing industry. So much so that new, disrupting technologies are announced almost every month. However, they can't all be disrupting and revolutionary. So it happens that when a truly disruptive new approach to 3D printing is announced it may go somewhat unnoticed – or fully understood for its importance. That may have happened when LLNL researchers first announced and presented volumetric 3D printing last year. But exactly what is volumetric 3D printing? E...

from A via a.sfakia on Inoreader https://ift.tt/2BijZ5K

Warming Cabinets for Clinical Product Storage

A safe and reliable environment is provided by Kingfisher solution and blanket warming cabinets for storing patient clinical products. Featuring the latest key and keypad locking options, the Kingfisher range offers optimum safety to the patient. Capacities: 145 and 228 L (blanket warming cabinets) and 72, 145, 176, and 228 L (solution warming cabinets) Standard Features Anti-bacterial outer coating Stainless steel radiused interior Tamper-proof controls Close temperature control...

from A via a.sfakia on Inoreader https://ift.tt/2UERt78

How CancerIQ helps OSF HealthCare identify patients at high risk of breast cancer

A few years ago, OSF HealthCare was looking for a way to identify women who had a high risk of breast cancer. After looking at another potential solution, the Peoria, Illinois-based system found CancerIQ, a Chicago startup that enables an organization to run a cancer risk assessment program. In a phone interview, CancerIQ co-founder and CEO Feyi Olopade explained her company's approach: "What we do for health systems is help them streamline the evaluation process so they can provide better...

from A via a.sfakia on Inoreader https://ift.tt/2BiKSXk

Colorectal Cancer Screening Pill to Be in US Pilot Study

Check-Cap is getting one step closer to having its capsule-based screening method for colorectal cancer on the U.S. market. The Isfiya, Israel-based company has received FDA conditional approval for an IDE to initiate a pilot study of the C-Scan capsule. FDA's conditional approval of the IDE requires Check-Cap to provide additional information to the agency and the company may begin enrolling patients immediately upon approval by the study site's Institutional Review Board (IRB). The trial...

from A via a.sfakia on Inoreader https://ift.tt/2UNu5Ev

The Case For Sexual Healing In Heart Patients

To understand the sexual status of post-coronary patients enrolled in an exercise-centered rehabilitation program, researchers collected questionnaires on sexual activity from 161 patients. The wives of 100 of these patients were also administered questionnaires for the study.The wives of these patients with reduced sexual activity reported their husbands being less willing to assume responsibility, having increased difficulty adjusting to life at home and in the workplace and being more neur...

from A via a.sfakia on Inoreader https://ift.tt/2BkNAvb

Cylindrical Autoclave for Laboratory Applications

Featuring one programmable cycle and eight preset cycles, the Labclave 23 has been specifically developed to provide fast and effective sterilization of a number of laboratory load types. The Labclave 23 is one of the most compact units available as it occupies a floor area of just 460 mm x 395 mm. Loading: Top Autoclave capacity: 23 L Heating source: In-chamber heaters Section: Cylindrical Standard Features Flexible control system Push-button door closure High-grade stainless st...

from A via a.sfakia on Inoreader https://ift.tt/2UMkr4Z

RESEARCH WORK

This year we celebrated 20-th anniversary of constant clinical research on KRIONs. From the very beginning, from the times when our specialists were working on the creating of the technology for cryosauna operation, the main aim was to find the most effective parameters for the proper WBC procedures. First years (from 1994) all our units were installed in the medical centres and hospitals. Thus, we collected the richest Best Practice in the Industry based on clinical research, clinic...

from A via a.sfakia on Inoreader https://ift.tt/2UNYXVk

New Corindus Technology Successfully Used in Robotic-Assisted Coronary Intervention

The future of robotic-assisted surgery emerges ever closer with the news of Corindus Vascular Robotics's new CorPath GRX System being successfully used to enable robotic-assisted percutaneous coronary interventions (PCI) at the recent Transcatheter Cardiovascular Therapeutics 2018 (TCT) conference. The technology was used to perform the first live transmission of a hybrid chronic total occlusion PCI using both manual and robotic techniques to successfully treat a patient suffering from a comp...

from A via a.sfakia on Inoreader https://ift.tt/2BjLc81

Study Links Air Pollution with Rescue Inhaler Use

A recent study concludes that there is a strong and significant association between daily exposure to fine particulate matter (PM2.5), which refers to tiny particles or droplets in the air that are two and a half microns or less in width, and the frequency of asthma rescue medication usage. Because the particulates are so small, they can get deep into the lungs and greatly affect respiratory conditions. "This study is unique in that it looked at how air pollution impacts someone's day-to-d...

from A via a.sfakia on Inoreader https://ift.tt/2UNu2Zl

Conference attendance boosts authorship opportunities

Conference attendance boosts authorship opportunities

Conference attendance boosts authorship opportunities , Published online: 14 December 2018; doi:10.1038/d41586-018-07772-5

Scientists who travel to meetings are more likely to co-author papers than are those who stay at home.

from A via a.sfakia on Inoreader https://ift.tt/2QNsvDF

[ASAP] Dielectric Behavior as a Screen in Rational Searches for Electronic Materials: Metal Pnictide Sulfosalts

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b10685
jacsat?d=yIl2AUoC8zA


from A via a.sfakia on Inoreader https://ift.tt/2GgyHzP

[ASAP] Reactivity of Solid Rubrene with Potassium: Competition between Intercalation and Molecular Decomposition

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b11231
jacsat?d=yIl2AUoC8zA


from A via a.sfakia on Inoreader https://ift.tt/2rEcYYB

[ASAP] Bioinspired Metal–Organic Framework Catalysts for Selective Methane Oxidation to Methanol

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b11525
jacsat?d=yIl2AUoC8zA


from A via a.sfakia on Inoreader https://ift.tt/2Gjj9eK

[ASAP] Total Enzyme Syntheses of Napyradiomycins A1 and B1

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b10134
jacsat?d=yIl2AUoC8zA


from A via a.sfakia on Inoreader https://ift.tt/2Gf4Xn3

Mini-tumours tell of immune cells’ role in cancer

Mini-tumours tell of immune cells' role in cancer

Mini-tumours tell of immune cells' role in cancer, Published online: 14 December 2018; doi:10.1038/d41586-018-07752-9

3D cultures detail the complex relationship between a tumour and its environment.

from A via a.sfakia on Inoreader https://ift.tt/2CaTDUM

2018: Choice cuts from this year’s News & Views articles

2018: Choice cuts from this year's News & Views articles

2018: Choice cuts from this year's News & Views articles, Published online: 14 December 2018; doi:10.1038/d41586-018-07686-2

Extracts from selected News & Views articles published this year.

from A via a.sfakia on Inoreader https://ift.tt/2QygnHk

[ASAP] Spotlights on Recent Publications

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b13292
jacsat?d=yIl2AUoC8zA


from A via a.sfakia on Inoreader https://ift.tt/2Ggfezl

[ASAP] Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b11891
jacsat?d=yIl2AUoC8zA


from A via a.sfakia on Inoreader https://ift.tt/2rEcYrz

[ASAP] Extended p-Conjugated Structures via Dehydrative C–C Coupling

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b09337
jacsat?d=yIl2AUoC8zA


from A via a.sfakia on Inoreader https://ift.tt/2rDFKZs

[ASAP] Identification of G-Quadruplex-Binding Protein from the Exploration of RGG Motif/G-Quadruplex Interactions

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b09329
jacsat?d=yIl2AUoC8zA


from A via a.sfakia on Inoreader https://ift.tt/2GhuI6g

[ASAP] Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C–C Bond Coupling

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b10136
jacsat?d=yIl2AUoC8zA


from A via a.sfakia on Inoreader https://ift.tt/2rEd0zH

Αναζήτηση αυτού του ιστολογίου

! # Ola via Alexandros G.Sfakianakis on Inoreader