Αρχειοθήκη ιστολογίου

Πέμπτη 27 Ιουλίου 2017

Salient-but-irrelevant stimuli cause attentional capture in difficult, but attentional suppression in easy visual search

Abstract

Search for a shape target is difficult when its shape is similar to the shape of the surrounding nontargets and easy when it is dissimilar. We asked whether interference from a salient but irrelevant color singleton depended on search difficulty as manipulated by target-nontarget similarity. We found that interference was strong in difficult searches, and the occurrence of an electrophysiological index of attentional selectivity (the N2pc component) confirmed that attention was captured by the distractor. In contrast, interference from the distractor was weak with easy searches, and the occurrence of the PD component confirmed that saliency signals from the distractor were suppressed. The results suggest that attentional suppression of salient but irrelevant distractors is only possible when search is efficient (i.e., with low target-nontarget similarity), otherwise, attentional capture occurs. Further, we analyzed the Ppc component, a positivity occurring between 100 and 200 ms after stimulus onset contralateral to a salient feature discontinuity. It has been suggested that the Ppc reflects bottom-up saliency signals, but we found the Ppc to occur only when the salient stimulus was unlikely to be selected, as in efficient searches. Thus, attentional requirements modulate the Ppc component.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2v4Lm1N
via IFTTT

Age-related shifts in hemispheric dominance for syntactic processing

Abstract

Recent ERP data from young adults have revealed that simple syntactic anomalies elicit different patterns of lateralization in right-handed participants depending upon their familial sinistrality profile (whether or not they have left-handed biological relatives). Right-handed participants who do not have left-handed relatives showed a strongly lateralized response pattern, with P600 responses following left-hemisphere-biased presentations and N400 responses following right-hemisphere-biased presentations. Given that the literature on aging has documented a tendency to change across adulthood from asymmetry of function to a more bilateral pattern, we tested the stability of this asymmetric response to syntactic violations by recording ERPs as 24 older adults (age 60+) with no history of familial sinistrality made grammaticality judgments on simple two-word phrases. Results showed that the asymmetric pattern observed in right-handed adults without familial sinistrality indeed changes with age, such that P600 responses come to be elicited not only with left-hemisphere-biased but also with right-hemisphere-biased presentations in older adults. These findings suggest that, as with many other cognitive functions, syntactic processing becomes more bilateral with age.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2eSwAVJ
via IFTTT

Choice predicts the feedback negativity

Abstract

Choosing the appropriate response given the circumstance is integral to all aspects of human behavior. One way of elucidating the mechanisms of choice is to relate behavior to neural correlates. Electrophysiological evidence implicates the ERP feedback-negativity (FN) and the P300 as promising neural correlates of reward processing, an integral component of learning. However, prior research has not adequately addressed how the development of a preference to select one option over another (choice preference) relates to the FN and the P300. We assessed whether variation in choice preference predicted the FN and P300 amplitude within subjects. We used a discrete-trials two-alternative choice procedure, where the reinforcer rate for each option was dependently scheduled by a concurrent variable interval. The reinforcer ratio for selecting each option was varied between sessions. Choice was quantified using both the generalized matching law sensitivity and the log odds of staying on the same versus switching to the other alternative (stay preference). The relationship between stay preference, FN, and P300 amplitudes was assessed using the innovative application of hierarchical Bayesian linear regression. The results demonstrate that stay preference was controlled by the reinforcer ratios and credibly predicted the FN amplitude but not P300 amplitude. The findings are consistent with the view that reinforcers may guide behavior by what they signal about future reinforcement, with the FN related to such a process.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2h8biE4
via IFTTT

Auditory-visual integration modulates location-specific repetition suppression of auditory responses

Abstract

Space is a dimension shared by different modalities, but at what stage spatial encoding is affected by multisensory processes is unclear. Early studies observed attenuation of N1/P2 auditory evoked responses following repetition of sounds from the same location. Here, we asked whether this effect is modulated by audiovisual interactions. In two experiments, using a repetition-suppression paradigm, we presented pairs of tones in free field, where the test stimulus was a tone presented at a fixed lateral location. Experiment 1 established a neural index of auditory spatial sensitivity, by comparing the degree of attenuation of the response to test stimuli when they were preceded by an adapter sound at the same location versus 30° or 60° away. We found that the degree of attenuation at the P2 latency was inversely related to the spatial distance between the test stimulus and the adapter stimulus. In Experiment 2, the adapter stimulus was a tone presented from the same location or a more medial location than the test stimulus. The adapter stimulus was accompanied by a simultaneous flash displayed orthogonally from one of the two locations. Sound-flash incongruence reduced accuracy in a same-different location discrimination task (i.e., the ventriloquism effect) and reduced the location-specific repetition-suppression at the P2 latency. Importantly, this multisensory effect included topographic modulations, indicative of changes in the relative contribution of underlying sources across conditions. Our findings suggest that the auditory response at the P2 latency is affected by spatially selective brain activity, which is affected crossmodally by visual information.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2eSw7Tt
via IFTTT

Updates in the Evaluation of Older Women with Pelvic Floor Disorders

Abstract

Purpose of Review

Pelvic floor disorders (PFDs) are common among older women, and pose a unique challenge to the healthcare provider. The onset of PFDs in older women is gradual resulting from an inter-related process of anatomic, hormonal, and functional changes that occur over time and often impacted by concomitant medical co-morbid conditions. In this evidenced-based review, we provide an update on the epidemiology and provide an evidence-based approach to the evaluation of women with PFDs with a specific focus on the impact of aging.

Recent Findings

Physical function impairment is prevalent among older women with pelvic floor symptoms. The decline in physical function is likely the consequence of global changes in skeletal muscle health with aging, but may uniquely impact the pelvic floor muscle physiology and function.

Summary

Providers caring for older women with PFDs must account for the impact of the aging process on symptom presentation and evaluation.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2h813Qu
via IFTTT

Comparative Effectiveness for Glycemic Control in Older Adults with Diabetes

Abstract

Purpose of Review

The purpose of this review is to summarize the current data for comparative effectiveness of glycemic control in older adults.

Recent Findings

In the last several years, professional societies have released guidelines for glycemic control in older adults, generally recommending individualized HbA1c goals. However, recent observational studies demonstrate that many older adults remain aggressively managed and are at increased risk of hypoglycemia. Large randomized trials of older adults with diabetes have failed to show convincing cardiovascular benefit from intensive glycemic control and suggest some microvascular benefit. Additionally, a few studies suggest that suboptimal glycemic control can increase the risk for geriatric syndromes. Emerging research suggests similar safety and efficacy of glucose-lowering therapies in older versus younger adults.

Summary

Overall, there is a paucity of data supporting the benefit of intensive glycemic control in older adults. More research is needed in this vulnerable population.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2eS3A0s
via IFTTT

NHS director who was arrested on suspicion of voyeurism resigns

Jonathan Fielden, NHS England's deputy medical director and director of specialised commissioning services, has resigned. In February he was arrested by police on suspicion of voyeurism.1In a...

recent?d=yIl2AUoC8zA recent?d=dnMXMwOfBR0 recent?i=29ASqRtHeLA:kt1MW2OkNTE:V_sGLiP recent?d=qj6IDK7rITs recent?i=29ASqRtHeLA:kt1MW2OkNTE:gIN9vFw recent?d=l6gmwiTKsz0 recent?d=7Q72WNTAKBA recent?i=29ASqRtHeLA:kt1MW2OkNTE:F7zBnMy recent?i=29ASqRtHeLA:kt1MW2OkNTE:-BTjWOF


from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2h7WoOl
via IFTTT

Diagnosis and early management of inflammatory arthritis

What you need to knowConsider inflammatory arthritis in anyone with acute or subacute onset of joint pain, early morning stiffness, and soft tissue swellingEarly diagnosis and treatment with disease...

recent?d=yIl2AUoC8zA recent?d=dnMXMwOfBR0 recent?i=aOWw3IQr-qI:VR3jXxerBn4:V_sGLiP recent?d=qj6IDK7rITs recent?i=aOWw3IQr-qI:VR3jXxerBn4:gIN9vFw recent?d=l6gmwiTKsz0 recent?d=7Q72WNTAKBA recent?i=aOWw3IQr-qI:VR3jXxerBn4:F7zBnMy recent?i=aOWw3IQr-qI:VR3jXxerBn4:-BTjWOF


from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2eSKozw
via IFTTT

IDUA mutational profile and genotype-phenotype relationships in UK patients with Mucopolysaccharidosis I

Abstract

Mucopolysaccharidosis Type I is a lysosomal storage disorder with varying degrees of phenotypic severity caused by mutations in IDUA. Over 200 disease-causing variants in IDUA have been reported. We describe the profile of disease-causing variants in 291 individuals with Mucopolysaccharidosis Type I for whom IDUA sequencing was performed, focussing on the UK subset of the cohort. A total of 63 variants were identified, of which 20 were novel, and the functional significance of the novel variants is explored. The severe form of Mucopolysaccharidosis Type I is treated with haematopoietic stem cell transplantation, known to have improved outcomes with earlier age at treatment. Developing genotype-phenotype relationships would therefore have considerable clinical utility, especially in the light of the development of newborn screening programs for Mucopolysaccharidosis Type I. Associations between genotype and phenotype are examined in this cohort, particularly in the context of the profile of variants identified in UK individuals. Relevant associations can be made for the majority of UK individuals based on the presence of nonsense or truncating variants as well as other associations described in this report.

This article is protected by copyright. All rights reserved



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2uDMust
via IFTTT

Dundee boy Benny, 11, shows 'phenomenal courage' after shock leukaemia diagnosis - Evening Telegraph

5979c06f76c58.jpg

Dundee boy Benny, 11, shows 'phenomenal courage' after shock leukaemia diagnosis
Evening Telegraph
"Benny is pretty much house-bound. If his temperature goes to 38 degrees or higher he has to be taken to Ninewells straight away and that's happened twice so far. His white blood cell count is so low." And Benny faces a long battle to overcome the cancer.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2u3ZhAZ
via IFTTT

Incidence and risk of cardiotoxicity in cancer patients treated with targeted therapies

S03057372.gif

Publication date: Available online 28 July 2017
Source:Cancer Treatment Reviews
Author(s): Matteo Santoni, Federico Guerra, Alessandro Conti, Alessandra Lucarelli, Silvia Rinaldi, Laura Belvederesi, Alessandro Capucci, Rossana Berardi
BackgroundCardiotoxicityis a serious side effect of molecularly targeted agents. The purpose of this study was to evaluate the incidence and Relative Risk (RR) of developing all-grade and high-grade cardiotoxicity in patients with solid tumors receiving targeted agents through a revised meta-analysis of available clinical trials.MethodsThe scientific literature regarding cardiotoxicity was extensively analyzed using MEDLINE, PubMed, Embase and Cochrane Central Register of Controlled Trials (CENTRAL). Eligible studies were selected according to PRISMA statement. Summary incidence, RR, and 95% CIs were calculated using random-effects or fixed-effects models based on the heterogeneity of selected studies.ResultsOur search yielded a total of 4998 clinical studies; of them, 31 trials were finally considered for this meta-analysis. A total of 28538 patients were included; 7995 of these patients had breast cancer (28%), 6151 (22%) prostate cancer and 14392 (50%) were treated for other malignancies. The highest RR of high-grade events was observed with Vandetanib (RR=7.71, 95% CI 1.04–56.99), followed by Ramucirumab (RR=5.0) and Aflibercept (RR=4.1). Grouping by drug category, the highest incidence of high-grade cardiotoxicity was shown by anti-VEGFR-TKIs (RR 5.62, 95% CI 1.49–21.24) and anti-VEGF mAbs/VEGF-trap (RR 1.82, 95% CI 1.24–2.69). Grouping by tumor type, the highest incidence of cardiotoxicity was observed in thyroid cancer (8%), followed by gastric cancer (4%).ConclusionsTreatment with targeted agents in cancer patients is correlated with a significant increase in the risk of cardiotoxicity. Frequent clinical monitoring should be emphasized when using these and newer biological agents.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2v2Bea6
via IFTTT

The Effect of Weekly Set Volume on Strength Gain: A Meta-Analysis

Abstract

Background

Strength training set organisation and its relationship to the development of muscular strength have yet to be clearly defined. Current meta-analytical research suggests that different population groups have distinctive muscular adaptations, primarily due to the prescription of the strength training set dose.

Objectives

We conducted a meta-analysis with restrictive inclusion criteria and examined the potential effects of low (LWS), medium (MWS) or high weekly set (HWS) strength training on muscular strength per exercise. Secondly, we examined strength gain variations when performing multi-joint or isolation exercises, and probed for a potential relationship between weekly set number and stage of subjects' training (trained versus untrained).

Methods

Computerised searches were performed on PubMed, MEDLINE, SWETSWISE, EMBASE and SPORTDiscus™ using the terms 'strength training', 'resistance training', 'single sets', 'multiple sets' and 'volume'. As of September 2016, 6962 potentially relevant studies were identified. After review, nine studies were deemed eligible per pre-set inclusion criteria. Primary data were pooled using a random-effect model. Outcomes for strength gain, strength gain with multi-joint and isolation exercise were analysed for main effects. Sensitivity analyses were calculated for several subgroups by separating the data set and by calculation of separate analyses for each subgroup. Heterogeneity between studies was assessed using the Cochran Q and I 2 statistics.

Results

Pre- versus post-training strength analysis comprised 61 treatment groups from nine studies. For combined multi-joint and isolation exercises, pre- versus post- training strength gains were greater with HWS compared with LWS [mean effect size (ES) 0.18; 95% CI 0.06–0.30; p = 0.003]. The mean ES for LWS was 0.82 (95% CI 0.47–1.17). The mean ES for HWS was 1.01 (95% CI 0.70–1.32). Separate analysis of the effects of pre- versus post-training strength for LWS or MWS observed marginally greater strength gains with MWS compared with LWS (ES 0.15; 95% CI 0.01–0.30; p = 0.04). The mean ES for LWS was 0.83 (95% CI 0.53–1.13). The mean ES for MWS was 0.98 (95% CI 0.62–1.34). For multi-joint exercises, greater strength gains were observed with HWS compared with LWS (ES 0.18; 95% CI 0.01–0.34; p = 0.04). The mean ES for LWS was 0.81 (95% CI 0.65–0.97). The mean ES for HWS was 1.00 (95% CI 0.77–1.23). For isolation exercises, greater strength gains were observed with HWS compared with LWS (ES 0.23; 95% CI 0.06–0.40; p = 0.008). The mean ES for LWS was 0.95 (95% CI 0.30–1.60). The mean ES for HWS was 1.10 (95% CI 0.26–1.94). For multi-joint and isolation exercise-specific one repetition maximum (1 RM), marginally greater strength gains were observed with HWS compared with LWS (ES 0.14; 95% CI −0.01 to 0.29; p = 0.06). The mean ES for LWS was 0.80 (95% CI 0.47–1.13). The mean ES for HWS was 0.97 (95% CI 0.68–1.26).

Conclusion

This meta-analysis presents additional evidence regarding a graded dose–response relationship between weekly sets performed and strength gain. The use of MWS and HWS was more effective than LWS, with LWS producing the smallest pre- to post-training strength difference. For novice and intermediate male trainees, the findings suggest that LWSs do not lead to strength gains compared with MWS or HWS training. For those trainees in the middle ground, not a novice and not advanced, the existing data provide a relationship between weekly sets and strength gain as set configurations produced different pre- to post-training strength increases. For well trained individuals, the use of either MWS or HWS may be an appropriate dose to produce strength gains.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2h8dEmm
via IFTTT

Design and evaluation of two multi-pinhole collimators for brain SPECT

Abstract

Objective

SPECT is a powerful tool for diagnosing or staging brain diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) but is limited by its inferior resolution and sensitivity. At the same time, pinhole SPECT provides superior resolution and detection efficiency trade-off as compared to the conventional parallel-hole collimator for imaging small field-of-view (FOV), which fits for the case of brain imaging. In this study, we propose to develop and evaluate two multi-pinhole (MPH) collimator designs to improve the imaging of cerebral blood flow and striatum.

Methods

We set the target resolutions to be 12 and 8 mm, respectively, and the FOV at 200 mm which is large enough to cover the whole brain. The constraints for system optimization include maximum and minimum detector-to-center-of-FOV (CFOV) distances of 344 and 294 mm, respectively, and minimal radius-of-rotation (ROR) of 135 mm to accommodate patients' shoulder. According to the targeted FOV, resolutions, and constraints, we determined the pinhole number, ROR, focal length, aperture acceptance angle, and aperture diameter which maximized the system sensitivity. We then assessed the imaging performance of the proposed MPH and standard low-energy high-resolution (LEHR) collimators using analytical simulations of a digital NCAT brain phantom with 99mTc-HMPAO/99mTc-TRODAT-1 distributions; Monte Carlo simulations of a hot-rod phantom; and a Defrise phantom using GATE v6.1. Projections were generated over 360° and reconstructed using the 3D MPH/LEHR OS-EM methods with up to 720 updates. The normalized mean square error (NMSE) was calculated over the cerebral and striatal regions extracted from the reconstructed images for 99mTc-HMPAO and 99mTc-TRODAT-1 simulations, respectively, and average normalized standard deviation (NSD) based on 20 noise realizations was assessed on selected uniform 3D regions as the noise index. Visual assessment and image profiles were applied to the results of Monte Carlo simulations.

Results

The optimized design parameters of the MPH collimators were 9 pinholes with 4.7 and 2.8 mm pinhole diameter, 73° acceptance angle, 127 mm focal length, 167 mm ROR for 12 mm and 8 mm target resolution, respectively. According to the optimization results, the detection efficiencies of the proposed collimators were 270 and 40% more as compared to LEHR. The Monte Carlo simulations showed that 7.9 and 6.4 mm rods can be discriminated for the MPH collimators with target resolutions of 12 and 8 mm, respectively. The eight 12 mm-thick discs of the Defrise phantom can also be resolved clearly in the axial plane as demonstrated by the image profiles generated with the MPH collimators.

Conclusion

The two collimator designs provide superior image quality as compared to the conventional LEHR, and shows potential to improve current brain SPECT imaging based on a conventional SPECT scanner.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2vd4Zpa
via IFTTT

Grandma covered face cancer with make up for months - Clarence Valley Daily Examiner

b88884027z1_20170726181906_000gqpng9mm2-

Grandma covered face cancer with make up for months
Clarence Valley Daily Examiner
In Queensland more than 740 people are diagnosed with head and neck cancer each year and about 250 people die from the disease. Head and neck cancers occur inside the sinuses, nose, mouth and throat, and salivary glands. Possible symptoms include ...



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2eS3jKG
via IFTTT

Grandma covered face cancer with make up for months - Clarence Valley Daily Examiner

b88884027z1_20170726181906_000gqpng9mm2-

Grandma covered face cancer with make up for months
Clarence Valley Daily Examiner
In Queensland more than 740 people are diagnosed with head and neck cancer each year and about 250 people die from the disease. Head and neck cancers occur inside the sinuses, nose, mouth and throat, and salivary glands. Possible symptoms include ...



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2h7xgHC
via IFTTT

Cryopreservation of Indian red jungle fowl (Gallus gallus murghi) semen with polyvinylpyrrolidone

Publication date: Available online 27 July 2017
Source:Cryobiology
Author(s): Bushra Allah Rakha, Muhammad Sajjad Ansari, Shamim Akhter, Zartasha Zafar, Iftikhar Hussain, Julian Santiago-Moreno, Elisabeth Blesbois
The Indian red jungle fowl is a sub-species of the genus Gallus native to South Asia; facing high risks of extinction in its native habitat. During cryopreservation, permeable cryoprotectants like glycerol are usually employed and we previously showed encouraging results with 20% glycerol. Because bird spermatozoa contain very little intracellular water, the possibility of replacing an internal cryoprotectant by an external one is opened. In the present study, we tested the replacement of internal cryoprotectant glycerol by the external cryoprotectant Polyvinylpyrrolidone (PVP). PVP is a non-permeable cryoprotectant and keeps the sperm in glassy state both in cooling and warming stages without making ice crystallization within the sperm cell. We evaluated the effect of various levels of polyvinylpyrrolidone (PVP) on Indian red jungle fowl semen quality and fertility outcomes. The qualifying semen ejaculates collected from eight mature cocks were pooled, divided into five aliquots, diluted (37 °C) with red fowl semen extender having PVP [0% (control) 4% (w/v), 6% (w/v), 8% (w/v) and 10% (w/v)]. Diluted semen was cryopreserved and stored in liquid nitrogen. The whole experiment was repeated/replicated for five times independently. Sperm motility, plasma membrane integrity, viability and acrosome integrity were recorded highest (P < 0.05) with 6% PVP at post-dilution, cooling, equilibration and freeze-thawing. Higher (P > 0.05) no. of fertile eggs, fertility, no. of hatched chicks, percent hatch and hatchability was recorded with 6% PVP compared to control. It is concluded that 6% PVP maintained better post-taw quality and fertility of Indian red jungle fowl spermatozoa than glycerol and can be used in routine practice avoiding the contraceptive effects of glycerol.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2u41so1
via IFTTT

Genomic characterization of an extensively-drug resistance Salmonella enterica serotype Indiana strain harboring blaNDM-1 gene isolated from a chicken carcass in China

S09445013.gif

Publication date: Available online 27 July 2017
Source:Microbiological Research
Author(s): Wei Wang, Zixin Peng, Zulqarnain Baloch, Yujie Hu, Jin Xu, Wenhui Zhang, Séamus Fanning, Fengqin Li
ObjectivesThe objective of this study was to genetically characterize the antimicrobial resistance mechanisms of Salmonella enterica serotype Indiana C629 isolated from a chicken carcass in China in 2014.MethodsAntimicrobial susceptibility against a panel of 23 antimicrobial agents was carried out on Salmonella enterica serotype Indiana C629 and assessed according to CLSI standards. Whole-genome sequencing of this isolate was conducted to obtain the complete genome of S. Indiana.ResultsSalmonella Indiana C629 expressed an XDR phenotype being resistant to more than 20 antimicrobial agents, including imipenem and meropenem. From the analysis of the resistance mechanisms, two mutations were identified in subunit A of DNA gyrase within the quinolone resistance determining region, in addition to the acquisition of mobile efflux pumps encoding oqxA/B/R. Additionally, four beta-lactamases resistance genes (blaCTX-M-65, blaTEM-1, blaOXA-1, and blaNDM-1), five aminoglycosides resistance genes (aac(3)-IV, aac(6′)-Ib-cr, aadA2, aadA5, and aph(4)-Ia), two phenicol resistance genes (catB3 and floR), and five trimethoprim/sulfamethoxazole resistance genes (sul1/2/3 and dfrA12/17) were also identified. A total of 191 virulence genes were identified. Among them, 57 belonged to type-three secretion system (T3SS) encoding genes, 55 belonged to fimbrial adherence encoding genes, and 39 belonged to flagella-encoding genesConclusionsThis study demonstrated that multi-resistance mechanisms consistent with an XDR-phenotype, along with various virulence encoding genes of a S. Indiana strain in China These findings highlight the importance of cooperation among different sectors in order to monitor the spread of resistant pathogens among food animal, foods of animal origin and human beings that might further take measures to protect consumers' health.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2vOGkUW
via IFTTT

The effect of high β-glucan flour incorporation into instant rice porridge on satiety and energy intake

Publication date: Available online 27 July 2017
Source:Bioactive Carbohydrates and Dietary Fibre
Author(s): Jowee Ng, Iain A Brownlee
Soluble dietary fibres such as oat β-glucan have been suggested to increase gastrointestinal viscosity to improve appetite regulation and reduce subsequent food intake. However, a paucity of research regarding the appetite-regulating effects of β-glucan in semisolid test meals exists. The aim of this study was to examine the appetite-regulating effects of instant rice porridge enriched with oat β-glucan on postprandial satiety and 24-hour prospective energy intake. In a crossover, single blind study design, seventeen healthy volunteers consumed instant rice porridge enriched with 1g oat β-glucan and control rice porridge. Appetite ratings at baseline and during the 210minutes following the consumption of test meals were recorded using visual analog scales (VAS). Food diaries were used to record dietary intake prospectively over a 24-hour period. No significant differences between treatments were observed in hunger, fullness, satiety, desire to snack and capacity to eat. However, consumption of the β-glucan enriched porridge resulted in a significant reduction (p = 0.026) in energy intake (1715 kJ) in the post-meal 24-hour period. Low doses of high-viscosity β-glucan-rich flour in a semisolid meal appeared to decrease prospective energy intake over 24hours, with no postprandial effects on appetite regulation within 210minutes.

Graphical abstract

image


from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2uHQ2bH
via IFTTT

The impact of supplementation with dietary fibres on weight loss: a systematic review of randomised controlled trials

Publication date: Available online 27 July 2017
Source:Bioactive Carbohydrates and Dietary Fibre
Author(s): Kia Yong Chew, Iain A Brownlee
The prevalence of excess body weight has significantly increased, with recent estimates suggesting 1.9 billion people are overweight or obese worldwide. While intake of dietary fibre (mainly from plant-based foods) is associated with improved weight management over time, it is uncertain whether dietary fibre isolates will benefit weight loss. The present study aimed to systematically assess the current evidence that dietary fibre supplementation can impact on weight loss in overweight adults. Blinded, randomised-controlled trials were retrieved from Scopus and Cochrane Central Register of Controlled Trials databases. Studies with free-living, overweight adult participants and fibre supplementation in various forms (i.e. as pills, capsules or powder mix formats) were included. A total of 32 trials were identified that met these criteria. Meta-analysis of statistically pooled data for chitosan (n=6) found significant increases in weight loss (effect size −0.42, 95% confidence interval: −0.81 to −0.03, P<0.001) in treatment groups compared with control groups. For glucomannan (n=5), non-significant difference was found (effect size −0.58, 95% confidence interval: −1.52 to 0.35, P<0.001). Risk of bias within included studies appeared to be low with mean scores of >3 on the Jadad scale and 13 studies scoring the highest possible value. Evidence on the potential impact of supplementation with other fibre types on weight loss was limited by a low number of studies and varied methodological approaches. Further research is recommended to explore these underlying issues to improve the paucity of evidence. A number of elements of study design should also be carefully considered in future work.

Graphical abstract

image


from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2uHA01f
via IFTTT

IJMS, Vol. 18, Pages 1640: Neuroendocrine Differentiation in Metastatic Conventional Prostate Cancer Is Significantly Increased in Lymph Node Metastases Compared to the Primary Tumors

IJMS, Vol. 18, Pages 1640: Neuroendocrine Differentiation in Metastatic Conventional Prostate Cancer Is Significantly Increased in Lymph Node Metastases Compared to the Primary Tumors

International Journal of Molecular Sciences doi: 10.3390/ijms18081640

Authors: Vera Genitsch Inti Zlobec Roland Seiler George Thalmann Achim Fleischmann

Neuroendocrine serum markers released from prostate cancers have been proposed for monitoring disease and predicting survival. However, neuroendocrine differentiation (NED) in various tissue compartments of metastatic prostate cancer is poorly described and its correlation with specific tumor features is unclear. NED was determined by Chromogranin A expression on immunostains from a tissue microarray of 119 nodal positive, hormone treatment-naïve prostate cancer patients who underwent radical prostatectomy and extended lymphadenectomy. NED in the primary cancer and in the metastases was correlated with tumor features and survival. The mean percentage of NED cells increased significantly (p &lt; 0.001) from normal prostate glands (0.4%), to primary prostate cancer (1.0%) and nodal metastases (2.6%). In primary tumors and nodal metastases, tumor areas with higher Gleason patterns tended to display a higher NED, although no significance was reached. The same was observed in patients with a larger primary tumor volume and higher total size and number of metastases. NED neither in the primary tumors nor in the metastases predicted outcome significantly. Our data suggest that (a) increasing levels of neuroendocrine serum markers in the course of prostate cancer might primarily derive from a poorly differentiated metastatic tumor component; and (b) NED in conventional hormone-naïve prostate cancers is not significantly linked to adverse tumor features.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2tIexnG
via IFTTT

Snake bite

Snake bites: A bite of a venomous snake, such as a rattlesnake, copperhead, cottonmouth water moccasin, or coral snake. A bite from one of these snakes should be considered a medical emergency. See also: Rattlesnake bite; Snake antivenin.



MedTerms (TM) is the Medical Dictionary of MedicineNet.com.
We Bring Doctors' Knowledge To You

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2w5kxb3
via IFTTT

Acquired pachydermatoglyphia: the cutaneous manifestation of pulmonary tumours

Description

A 74-year-old man with active smoking habits presented to the emergency department with a 2-month history of weight loss (20% of previous body mass), dyspnoea and night sweats. Physical examination showed clinical signs of respiratory distress, significant cachexia and thickened velvety palms with pronounced folds (figure 1). The laboratory results revealed leucocytosis of 15 700 cells/µl, thrombocytosis of 547 000/µl and elevated C reactive protein of 6.65 mg/dL. A posteroanterior chest radiograph showed a right pleural effusion and consolidation suggestive of pneumonia.

Figure 1

Thickened velvety palms with pronounced folds consistent with acquired pachydermatoglyphia.

The patient was given antibiotics and submitted to pleural effusion drainage for symptomatic relief. A skin biopsy of the palms was obtained and the histopathological examination identified signs of hyperkeratosis, acanthosis and papillomatosis consistent with acquired pachydermatoglyphia (figure 2).

Figure 2

Skin biopsy consistent with acquired...



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2h7zxm2
via IFTTT

Bacteraemia and liver abscess due to Fusobacterium necrophorum

Fusobacterium necrophorum is the oropharyngeal pathogen usually associated with Lemierre's syndrome, a pharyngeal infection which evolves to sepsis, septic emboli and thrombophlebitis of the adjacent neck vessels. It is an uncommon causative bacteria of a liver abscess, and an extensive workup should, therefore, be performed in order to rule out potential sources of the infection. This case report describes the workup that led to the diagnosis of a colorectal carcinoma, which was deemed to be the source of the Fusobacterium bacteraemia.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2eSy2aC
via IFTTT

Hypertrophic olivary degeneration

Description

A 30-year-old man underwent MRI of the internal auditory meatus as a routine follow-up after excision of a large left vestibular schwannoma, 2.5 years previously. MRI images showed an incidental finding of left hypertrophic olivary degeneration (figure 1 and figure 2). This phenomenon occurs as a result of Wallerian degeneration of the olivary nucleus secondary to a lesion in the triangle of Guillain and Mollaret, also known as the dento-rubro-olivary pathway (figure 3). The differential diagnoses of hypertrophic olivary degeneration include infarction, infection, neoplasms and demyelination. Differentials can be excluded by the absence contrast enhancement (figure 2).

Figure 1

Axial T2-weighted sequence showing intratumoral haemorrhage within a large left cerebello-pontine angle lesion in keeping with a vestibular schwannoma (panel A). Axial fluid attenuated inversion recovery (FLAIR) image through the posterior fossa after 6 months demonstrating atrophic changes and haemosiderin deposition in the left middle cerebellar peduncle...



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2h88Zkm
via IFTTT

Hiatal hernia mimicking heart problems

Description

A 73-year-old man presented to the emergency department with symptoms of acute coronary syndrome. Findings on examination were dyspnoea, chest tightness and a burning sensation behind the sternum.

On admission, 3 hours after the onset of symptoms, his 12-lead ECG showed a left bundle branch block. Cardiac enzymes revealed only marginally elevated creatine kinase, aspartate transaminase and lactate dehydrogenase levels; however, troponin I (<0.04 ng/mL) was increased to 17 and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) to 1472 pg/mL (73 year normal range: 10–220 pg/mL). Though the consulting cardiologist determined coronary angiography to be unnecessary at the time, the patient was promptly sent to the intensive care unit (ICU) for monitoring and for quick intervention, if needed.

At that time, further information was gathered from the patient and his family. Apparently, the symptoms had started during lunch. The patient had experienced these symptoms several times in the preceding months; this time, however, the...



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2eSd8IM
via IFTTT

Postoperative gluteal compartment syndrome following microsurgical free-flap hand reconstruction: the importance of early recognition and treatment

Compartment syndrome, a surgical emergency, is caused by an increase in pressure within a closed osseofascial space, often due to trauma. This causes a decrease in tissue perfusion and ultimately tissue necrosis and multiorgan failure if not treated in a timely fashion. Gluteal compartment syndrome is a rare variant and often caused by a period of immobilisation secondary to intoxication with alcohol or drugs or during long operations, typically in the supine position. We report on a case of gluteal compartment syndrome developing in a patient postoperatively following a long microsurgical procedure to a hand, which has not been documented before. Although rare, we highlight the clinical course and diagnostic criteria, which are essential for early identification and treatment.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2h7NP6i
via IFTTT

Adjunctive extracorporeal carbon dioxide removal in refractory status asthmaticus

Status asthmaticus (SA) is a life-threatening disorder. Severe respiratory failure may require extracorporeal membrane oxygenation (ECMO). Previous reports have demonstrated utility of ECMO in SA in various patients with varying success. A 25-year-old man was admitted with status asthmatics and severe hypercapnic respiratory failure. Despite tailored ventilator therapies, such as pressure control ventilation and maximal pharmacological therapy, including general anaesthesia, the patientâ™s condition deteriorated rapidly. Veno-venous ECMO (VV-ECMO) was provided for respiratory support. The patientâ™s clinical condition improved over the following 72âhours and was discharged from the intensive care unit on day 3. This case report demonstrates the successful use of VV-ECMO in a patient with severe respiratory failure due to SA, who failed to respond to maximal therapy. This case adds support to a growing body of literature that shows that ECMO can be used with success for refractory status asthmaticus.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2eS6aU7
via IFTTT

Intraparotid ductal ectasia: rare cause of parotid swelling

A 41-year-old patient was hospitalised for a chronic right parotid mass. A cervical ultrasound revealed a cystic mass of the parotid. Cervical MRI found a ductal ectasia of the parotid and submandibular glands associated with a retention cyst of the right parotid. He had a right total parotidectomy. Histopathological examination of the lesion revealed a multilocular cystic mass with a diffuse glandular ectasia of salivary ducts. The patient had an uneventful postoperative course without any recurrence of symptoms.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2h7zkPM
via IFTTT

Gamna-Gandy nodules of the spleen and asplenism in SLE: a novel association?

Description

We present a case of a 53-year-old woman who presented to the emergency room with acute abdominal pain, fever and haemodynamic and respiratory instability and was admitted to the intensive care unit with fulminant septic shock with multiorgan failure. CT imaging of the abdomen showed no gross abnormalities, initial laboratory results are presented in table 1.

Table 1

Laboratory test results

ParameterValueReference valueUnitCRP96<10mg/LESR7<20mm/hourHb8.07.0–9.2mmol/LHt0.400.32–0.44L/LMCV9582–89fLWBC6.5

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2eRQxw0
via IFTTT

Extramacular dome-shaped elevation: a novel finding in a case of high myopia

Description

Dome-shaped macula (DSM) is an elevation at the macula seen in about 5%–10% cases of high myopia, usually within a posterior staphyloma, caused by localised inward scleral and choroidal convexity.1 It may lead to visual deterioration when associated with serous foveal detachment (44% cases).2 3 Herein, we describe a similar but 'Extramacular dome-shaped elevation (EDSE)' associated with a large retinal hole.

A 23-year-old myopic female patient was referred to our clinic for pre refractive surgery fundus screening. She had a history of diminution of vision in the left eye more than the right eye since childhood and was using myopic glasses for the same. Best-corrected visual acuity on Snellen chart was 20/20 in the right eye and 20/200 in the left eye. Lower acuity in the left eye was attributed to anisometropic amblyopia as her refractive error was –6.75 D sphere...



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2h7R0ut
via IFTTT

Sclerosing lymphangitis of the penis associated with marked penile oedema and skin erosions

Sclerosing lymphangitis of the penis is a benign, under-reported condition consisting of a asymptomatic firm cord-like swelling around the coronal sulcus of the penis usually affecting men in the second or third decade of life. Penile oedema and erosions are rarely reported. Clinical signs may be remarkable contrasting with the self-limited character of the disease. We report a new case of sclerosing lymphangitis of the penis occurring in a 59-year-old patient marked by penile swelling and several overlying skin erosions, and discuss the clinical features and the pathogenesis aspects of the disease.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2eSURL6
via IFTTT

Accidental hypothermic cardiac arrest and rapid mediastinal warming with pleural lavage: a survivor after 3.5 hours of manual CPR

A 30-year-old man suffered post-traumatic hypothermic cardiac arrest. On arrival in the emergency department, rectal core temperature was 23°C. Manual cardiopulmonary resuscitation (CPR) was continued as no mechanical chest compression device was available, and active and passive rewarming was undertaken. Bilateral thoracostomies confirmed good lung inflation. Defibrillation and intravenous epinephrine were discontinued until core temperature was elevated above 30°C. Extracorporeal rewarming was unavailable. When no increase in rectal temperature was achieved after 90 min, an alternative oesophageal probe confirmed mediastinal temperature as 23°C. Bilateral chest drain insertion, followed by microwave-heated saline pleural lavage, rapidly raised the oesophageal temperature above 30°C with subsequent successful defibrillation, initially to pulseless electrical activity and finally return of spontaneous circulation 3.5 hours after the commencement of CPR. The patient recovered fully and was discharged without neurological deficit. Rapid mediastinal warming with pleural lavage should be considered in units with no access to extracorporeal rewarming service.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2eS5sWX
via IFTTT

Disseminated tuberculosis in relatively asymptomatic young woman

Description

A previously healthy 20-year-old woman presented to the emergency department with a history of one episode of generalised tonic–clonic seizure. No history of fever or constitutional symptoms. At admission, she was haemodynamically stable and Glasgow Coma Scale was 8, with no focal neurological deficits. For the workup of seizures, MRI brain (figure 1) was done which revealed multiple ring-enhancing lesions in bilateral temporal, frontal and right parietal lobes. Cerebrospinal fluid examination showed normal cell count with high protein (84 mg/dL) and normal glucose levels (43 mg/dL), and high adenosine deaminase (9.3 U/L) level. Chest X-ray showed (figure 2A) miliary mottling which was confirmed by contrast-enhanced CT (CECT) chest (figure 2B and C). CECT abdomen (figure 3A and B) revealed thick-walled multiloculated collection (7.3x8.4x14.2 cm) with thick internal septations in the left lumbar and iliac fossa region. Pelvic collections were drained with an image-guided pig tail insertion and...



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2h7QVqF
via IFTTT

A perforated caecal volvulus in the foramen of Winslow

The aim of this report is to discuss with high-quality images, a case of a caecal volvulus herniating through the foramen of Winslow with signs of perforation.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2v4UMu9
via IFTTT

Processing of calamine with modern analytical techniques: Processed with Huanglian Decoction (黄连汤) and Sanhuang Decoction (三黄汤)

Abstract

Objective

To determine the pyrolysis characteristics of calcined and processed calamine, qualitatively and quantitatively compare the contents of related elements, morphology and functional groups of the pyrolysis products dried at different heating temperatures and explore the critical temperature and the optimal drying temperature for the process of calamine with Huanglian Decoction (HLD, 黄连汤) and San Huang Decoction (SHD, 三黄汤).

Methods

Pyrolysis products were prepared by programmable and constantly heating the calcined and processed calamine to or at different heating temperatures. Thermogravimetry (TG) was used to test their pyrolysis characteristics. Fourier transform infrared spectroscopy and scanning electron microscopeenergy dispersive spectrometer were used to determine their morphology, functional groups and element contents. Page model was used to investigate the constant drying kinetics of processed calamine.

Results

The adding of HLD or SHD to calcined calamine (CC) can slow its weight loss in drying pyrolysis process. The temperature ranges where HLD and SHD can affect its weight loss were 65–150 °C and 74–180 °C, respectively. The drying temperature was optimized as 90 °C. The drying kinetic for the processed calamine fits Page model shows good linearity.

Conclusions

The critical temperature and the optimal drying temperature where HLD and SHD can affect the weight loss rate in the process of calamine were explored using the theories and methods of both biophysical chemistry and processing of Chinese materia medica. This work provides a good example for the study of the process of other Chinese medicines using modern analytical techniques.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2u3em5U
via IFTTT

Mechanically Loading Cell/Hydrogel Constructs with Low-Intensity Pulsed Ultrasound for Bone Repair

Tissue Engineering Part A , Vol. 0, No. 0.


from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2u3d0Im
via IFTTT

Human Plasma Rich in Growth Factors Improves Survival and Neurite Outgrowth of Spiral Ganglion Neurons In Vitro

Tissue Engineering Part A , Vol. 0, No. 0.


from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2tOfEX6
via IFTTT

MANDIBULAR PSEUDOCARCINOMATOUS HYPERPLASIA: A RARE POSTOPERATIVE COMPLICATION AND MANAGEMENT

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): LUCIANA YAMAMOTO DE ALMEIDA, CÁSSIO EDVARD SVERZUT, ALEXANDRE ELIAS TRIVELLATO, JESSICA LUANA DOS SANTOS, ALFREDO RIBEIRO DA SILVA, LANA KEI YAMAMOTO ALMEIDA, JORGE ESQUICHE LEÓN




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2tIpgP9
via IFTTT

HISTOPLASMOSIS IN AN HIV-INFECTED PATIENT: REPORT OF AN UNUSUAL CLINICAL MANIFESTATION

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): FELIPE MARTINS SILVEIRA, ANA PAULA NEUTZLING GOMES, SANDRA BEATRIZ CHAVES TARQUÍNIO, THAÍSE GOMES E NÓBREGA, KARINE DUARTE DA SILVA, ANA CAROLINA UCHOA VASCONCELOS




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2v4nHhY
via IFTTT

THE USE OF L-PRF (LEUKOCYTE-PLATELET-RICH FIBRIN) IN THE TREATMENT OF MRONJ

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): GUSTAVO MALUF DIB VALERIO, GABRIELLE SCATTOLIN MOREIRA, ANDRÉ LINS CAVALCANTI CORRÊA DA COSTA, EDUARDO FREGNANI, PAULO SÉRGIO SILVA SANTOS




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2v4pMdK
via IFTTT

Information for Readers

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2





from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2tIr1LS
via IFTTT

PRIMARY CUTANEOUS CD8+ T-CELL LYMPHOMA: CASE REPORT SHOWING FACIAL EDEMA WITH MARKED SWELLING OF EYELID AND LIP

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): DAPHINE CAXIAS TRAVASSOS, ELAINE MARIA SGAVIOLI MASSUCATO, CLÁUDIA MARIA NAVARRO, ALFREDO RIBEIRO DA SILVA, ANDREIA BUFALINO, LUCIANA YAMAMOTO DE ALMEIDA, JORGE ESQUICHE LEÓN




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2v4P0bK
via IFTTT

HUMAN PAPILLOMAVIRUS-ASSOCIATED ORAL EPITHELIAL DYSPLASIA

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): SANDRA R. TORRES, WLADIMIR CORTEZZI, ELLEN BRILHANTE CORTEZZI, MICHELLE AGOSTINI, ALICIA RUMAYOR PIÑA, BRUNO AUGUSTO BENEVENUTO DE ANDRADE, MÁRIO JOSÉ ROMAÑACH




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2tHYQwL
via IFTTT

Editorial Board

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2





from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2v4Qd2Z
via IFTTT

SURGICAL TREATMENT OF BOTRYOID ODONTOGENIC CYST WITH IMMEDIATE AUTOGENOUS BONE GRAFT

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): HENRIQUE CÔRTES MEIRA, MARIA CASSIA FERREIRA DE AGUIAR, PATRÍCIA CARLOS CALDEIRA, VAGNER RODRIGUES SANTOS, MARIA LETÍCIA FERREIRA ARAÚJO, IGRAINE CRISTINA RODRIGUES VIDAL, RICARDO ALVES MESQUITA




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2tI2vuG
via IFTTT

CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS OF THE MANDIBLE

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): AGUIDA MARIA MENEZES AGUIAR MIRANDA, FÁBIO RAMÔA PIRES, JULIANA DE NORONHA SANTOS NETTO, SIMONE MACEDO AMARAL, MARIA DA GLÓRIA MERI LEÃO, MARIANA CAPITÃO




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2v4E6Tn
via IFTTT

ORAL LESION COMPATIBLE WITH HPV WITH POSTERIOR SQUAMOUS CELL CARCINOMA

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): JOSE FERREIRA MENEZES FILHO, VIVIANE SILVA SIQUEIRA, ANELISE RIBEIRO PEIXOTO ALENCAR, FABRÍCIO PASSADOR SANTOS, ANDRESA BORGES SOARES, RUFINO KLUG




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2v4eFS0
via IFTTT

AN UNUSUAL PRESENTATION OF FACIAL INFILTRATING LIPOMATOSIS

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): MARIANNA SAMPAIO SERPA, ANA PAULA MOLINA VIVAS, MATHEUS HENRIQUE ALVES DE LIMA, RENATA MENDONÇA MORAES, JOSÉ SATURNINO DA SILVA, FELIPE D'ALMEIDA COSTA, FÁBIO ABREU ALVES




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2tIpeXx
via IFTTT

ESTOMATONET: TELEDIAGNOSIS IN ORAL MEDICINE IMPROVING THE ACCESS OF PRIMARY CARE PATIENTS TO SPECIALIZED TREATMENT

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): VINICIUS COELHO CARRARD, MICHELLE ROXO GONÇALVES, JÉSSICA RODRIGUEZ STREY, CARLOS PILZ, MARCELO RODRIGUES GONÇALVES, MARCO ANTONIO TREVIZANI MARTINS, ERNO HARZHEIM




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2v4bZnl
via IFTTT

ORAL METASTATIC BREAST ADENOCARCINOMA IN A MALE PATIENT

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): NATHALIA DE ALMEIDA FREIRE, NATHALIE HENRIQUES DA SILVA CANEDO, MICHELLE AGOSTINI, BRUNO AUGUSTO BENEVENUTO DE ANDRADE, MÁRIO JOSÉ ROMAÑACH




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2tIr22o
via IFTTT

ORAL MANIFESTATION OF MUCORMYCOSIS IN A BONE MARROW TRANSPLANTED PATIENT

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): BERNAR MONTEIRO BENITES, FELIPE PAIVA FONSECA, CLAUDIA PARAHYBA JOFFILY, YANA AUGUSTA SARKIS NOVIS, SERGIO SAMIR ARAP, RAFAEL SARLO VILELA, EDUARDO RODRIGUES FREGNANI




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2v4D3D4
via IFTTT

ODONTOGENIC CARCINOMA WITH DENTINOID: A CASE REPORT OF AN UNUSUAL MALIGNANT TUMOR

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): ROGERIO GONDAK, KATYA PULIDO DÍAZ, MARISOL MARTÍNEZ MARTÍNEZ, LEANDRO AURELIO LIPORONI MARTINS, PABLO AGUSTIN VARGAS, ADALBERTO MOSQUEDA-TAYLOR




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2tHYOVF
via IFTTT

FIRST AND FATAL MANIFESTATION OF ACQUIRED IMMUNODEFICIENCY SYNDROME

alertIcon.gif

Publication date: August 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 124, Issue 2
Author(s): DANIELA ASSIS DO VALE, DANIELLE LIMA CORRÊA DE CARVALHO, MARÍLIA TRIERVEILER, KAREM LÓPEZ ORTEGA




from ! ORL Sfakianakis via paythelady.61 on Inoreader http://ift.tt/2v4zg8z
via IFTTT

Allogeneic Reduced-Intensity Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease: a Single-Center Prospective Trial

Abstract

Purpose

The purpose of this study was to evaluate engraftment and adverse events with a conditioning and prophylactic regimen intended to achieve high rates of engraftment with minimal graft-versus-host disease (GVHD) in allogeneic transplantation for chronic granulomatous disease in a single center.

Methods

Forty patients, 37 male, with chronic granulomatous disease were transplanted. Transplant products were matched sibling peripheral blood stem cells (PBSCs) in four and matched unrelated donor (MUD) bone marrow in three, and one patient received mismatched unrelated PBSCs. Thirty-two patients received MUD PBSCs. All patients received a conditioning regimen of busulfan/alemtuzumab (with low-dose total body irradiation for MUD recipients) with sirolimus graft-versus-host disease prophylaxis.

Results

Engraftment occured in 38/40 recipients (95%). Acute or chronic GVHD occurred in 18 (45%) and 5 (12.5%), respectively, with 6 episodes of grades III–IV and/or steroid refractory GVHD. Overall survival was 33/40 (82.5%) and event-free survival was 30/40 (80%). Successful engraftment was associated with myeloid and NK cell, but not CD3+ chimerism. Myeloid engraftment was greater than 70% in 30/32 recipients at mean follow-up of 3.4 years. Evidence of persistent immunodeficiency was not seen in successful transplants. Attempts to rescue failed or poorly functioning grafts were associated with unacceptable morbidity and mortality.

Conclusions

A reduced-intensity allogeneic transplant protocol based on alemtuzumab and busulfan with sirolimus GVHD prophylaxis produced high rates of successful engraftment and minimal regimen-related toxicity. Prolonged clinical follow-up has confirmed its efficacy in ameliorating CGD-related disease. Outcomes were not acceptable with donor cell infusion rescue of cause with poor graft function.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2eSgXhb
via IFTTT

A Phase I study to determine safety, pharmacokinetics, and pharmacodynamics of ANF-RHO™, a novel PEGylated granulocyte colony-stimulating factor, in healthy volunteers

Summary

Patients receiving pegfilgrastim (Neulasta®) for the treatment of neutropenia can experience bone pain following the injections required to achieve effective neutrophil levels. The safety, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of ANF-RHO™, a novel pegylated granulocyte colony stimulating factor, were assessed in a randomized, controlled, double-blind Phase 1 clinical study in healthy volunteers. Subjects received a single subcutaneous dose of ANF-RHO over a range of 6 doses (5–50 μg/kg), placebo (saline), or the recommended clinical dose of pegfilgrastim administered at the labeled fixed 6 mg dosage (equivalent to 80–100 μg/kg). The primary outcome measure was safety and tolerability. Secondary outcomes included PK and PD effects on absolute neutrophil count (ANC) and number of CD34+ progenitor cells. Severity of bone pain was also assessed. In healthy volunteers, ANF-RHO was administered at ascending doses up to 50 μg/kg without significant adverse effects; appeared to be better (5 to 30 μg/kg) or equally well (50 μg/kg) tolerated, and had lower mean bone pain scores as compared to pegfilgrastim. ANF-RHO achieved CD34+ and ANC numbers at significantly lower doses, and had a significantly longer circulating half-life than pegfilgrastim. These results suggest that ANF-RHO can be provided less frequently, at a lower dose, and with fewer side effects. ANF-RHO had unique, prolonged PK/PD attributes as compared to marketed pegfilgrastim, suggesting that it may provide an improved clinical benefit in further clinical studies in patients with chemotherapy-induced or chronic idiopathic neutropenia.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2uHTvXu
via IFTTT

IJMS, Vol. 18, Pages 1625: High Salt Tolerance of a Bradyrhizobium Strain and Its Promotion of the Growth of Stylosanthes guianensis

IJMS, Vol. 18, Pages 1625: High Salt Tolerance of a Bradyrhizobium Strain and Its Promotion of the Growth of Stylosanthes guianensis

International Journal of Molecular Sciences doi: 10.3390/ijms18081625

Authors: Rongshu Dong Jie Zhang Hengfu Huan Changjun Bai Zhijian Chen Guodao Liu

Salinity is a serious limiting factor for the growth of rhizobia. Some rhizobia are tolerant to salt stress and promote plant growth, but the mechanisms underlying these effects are poorly characterized. The growth responses and osmoprotectants in four Bradyrhizobium strains were examined under salt stress in this study. Two-dimensional electrophoresis (2-DE) and mass spectrometry were conducted to investigate protein profiles in rhizobia exposed to salt stress. Subsequently, salt tolerance in stylo (Stylosanthes guianensis) inoculated with rhizobia was further detected in hydroponics. Results showed that the Bradyrhizobium strain RJS9-2 exhibited higher salt tolerance than the other three Bradyrhizobium strains. RJS9-2 was able to grow at 0.35 M NaCl treatment, while the other three Bradyrhizobium strains did not grow at 0.1 M NaCl treatment. Salt stress induced IAA production, and accumulation of proline, betaine, ectoine, and trehalose was observed in RJS9-2 but not in PN13-1. Proteomics analysis identified 14 proteins regulated by salt stress in RJS9-2 that were mainly related to the ABC transporter, stress response, and protein metabolism. Furthermore, under saline conditions, the nodule number, plant dry weight, and N concentration in stylo plants inoculated with RJS9-2 were higher than those in plants inoculated with PN13-1. These results suggest that the tolerance of RJS9-2 to salt stress may be achieved by the coordination of indole-3-acetic acid (IAA) production, osmoprotectant accumulation, and protein expression, thus promoting stylo growth.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2tO7TAz
via IFTTT

A mosquito hemolymph odorant-binding protein family member specifically binds juvenile hormone. [Lipids]

Juvenile hormone (JH) is a key regulator of insect development and reproduction. In adult mosquitoes, it is essential for maturation of the ovary and normal male reproductive behavior, but how JH distribution and activity is regulated after secretion is unclear. Here, we report a new type of specific JH-binding protein, given the name mosquito juvenile hormone binding protein (mJHBP), which circulates in the hemolymph of pupal and adult Aedes aegypti males and females. mJHBP, is a member of the odorant-binding protein (OBP) family, and orthologs are present in the genomes of Aedes, Culex and Anopheles mosquito species. Using isothermal titration calorimetry, we show that mJHBP specifically binds JH II and JH III, but not eicosanoids or JH derivatives. mJHBP was crystallized in the presence of JH III and found to have a double OBP domain structure reminiscent of salivary "long" D7 proteins of mosquitoes. We observed that a single JH III molecule is contained in the N-terminal domain binding pocket that is closed in an apparent conformational change by a C-terminal domain-derived α-helix. The electron density for the ligand indicated a high occupancy of the natural 10R enantiomer of JH III. Of note, mJHBP is structurally unrelated to hJHBP from lepidopteran insects. A low level of expression of mJHBP in Ae. aegypti larvae suggests that it is primarily active during the adult stage where it could potentially influence the effects of JH on egg development, mating behavior, feeding or other processes.

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2vd1lvw
via IFTTT

Kinetic Analyses of Single-Strand Break Repair by Human DNA Ligase III Isoforms Reveals Biochemical Differences from DNA Ligase I [Enzymology]

Humans have three genes encoding DNA ligases with conserved structural features and activities, but they also have notable differences. The LIG3 gene encodes a ubiquitous isoform in all tissues (LIG3α) and a germ line-specific splicing isoform (LIG3β) that differ in the C-terminal domain. Both isoforms are found in the nucleus and the mitochondria. Here, we determined the kinetics and thermodynamics of single-strand break ligation by LIG3α and LIG3β, and compared this framework to that of LIG1, the nuclear replicative ligase. The kinetic parameters of the LIG3 isoforms are nearly identical under all tested conditions, indicating the BRCT domain specific to LIG3α does not alter ligation kinetics. Although LIG3 is only 22% identical to LIG1 across their conserved domains, the two enzymes had very similar maximal ligation rates. Comparison of the rate and equilibrium constants for LIG3 and LIG1 nevertheless revealed important differences. The LIG3 isoforms were 7 times more efficient than LIG1 at ligating nicked DNA under optimal conditions, mainly because of their lower KM value for the DNA substrate. This could explain why LIG3 is less prone to abortive ligation than LIG1. Surprisingly, the affinity of LIG3 for Mg2+ was 10 times weaker than that of LIG1, suggesting that Mg2+ availability regulates DNA ligation in vivo, as Mg2+ levels are higher in the mitochondria than in the nucleus. The biochemical differences between the LIG3 isoforms and LIG1 identified here will guide the understanding of both unique and overlapping biological roles of these critical enzymes.

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2w4STuI
via IFTTT

The interleukin-like epithelial-mesenchymal transition inducer ILEI exhibits a non-interleukin-like fold and is active as a domain-swapped dimer [Protein Structure and Folding]

Production and secretion of pro-metastatic proteins is a feature of many tumor cells. The FAM3C Interleukin-like epithelial-to-mesenchymal-transition (EMT) inducer, ILEI has been shown to be strongly up-regulated in several cancers and to be essential for tumor formation and metastasis in epithelial cells, correlating with a significant decrease in overall survival in colon and breast cancer patients. ILEI has been seen to interact with the γ-secretase presenilin 1 subunit (PS1). However, not much is known about the mechanism-of-action or the detailed ILEI structure. We here present the crystal structures of FAM3C ILEI and show that it exists as monomers but also as covalent dimers. The observed ILEI β-β-α fold confirmed previous indications that the FAM3C proteins do not form classical four-helix-bundle structures as was initially predicted. This provides the first experimental evidence that the Interleukin-like EMT-inducers are not evolutionarily related to the interleukins. However, more surprisingly the ILEI dimer structure was found to feature a trans-linked domain swap, converting an intramolecular disulfide to intermolecular. Interestingly, dimeric but not monomeric ILEI was subsequently found to cause a dose-dependent increase in EpRas cell invasiveness comparable to TGF-β, indicating that the dimer might be the active ILEI species. This is in line with a parallel study showing that covalent oligomerization of ILEI is essential for EMT and tumor progression in vivo. The structures and the activity data gives some first insight into the relationship between dimerization and ILEI function as well as indicate an intriguing link between ILEI, the PS1-protease, TGF-β and the TGF-β receptor 1.

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2w4Tnkf
via IFTTT

Interpace Diagnostics Announces Cigna Coverage of ThyGenX® - Nasdaq

0081f742-38d0-48e7-8ba7-82d5db3599ee?siz

Click Daily Finance
Interpace Diagnostics Announces Cigna Coverage of ThyGenX®
Nasdaq
ThyGenX utilizes state-of-the-art next-generation sequencing (NGS) to identify more than 100 genetic alterations associated with papillary and follicular thyroid carcinomas, the two most common forms of thyroid cancer. According to the American Cancer ...
Interpace Diagnostics Group, Inc. (NASDAQ:IDXG) Files An 8-K Other EventsMarket Exclusive

all 17 news articles »


from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2uDnMsn
via IFTTT

Ipsilateral radial and ulnar artery cannulation during the same coronary catheterization procedure

249-IMG01.jpg

CASE SERIES

Hippokratia 2016, 20(3):249-251

Koutouzis M1, Ziakas A2, Didagelos M2, Maniotis C1, Kyriakides Z1
1Cardiology Department, Red Cross General Hospital, Athens, 21st Cardiology Department, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2tHYwOr
via IFTTT

Left atrial appendage pericardial fluid: contrast-enhanced transesophageal echocardiography makes it visible

235-IMG01.jpg

CASE REPORT

Hippokratia 2016, 20(3):235-237

Kamperidis V1, Michou E1, Kouskouras K2, Nikolaidou O2, Karvounis H1
1
1st Cardiology Department, 2Radiology Department, AHEPA Hospital, Medical Faculty, Aristotle University of Thessaloniki, Thessaloniki, Greece



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2tI0M8o
via IFTTT

The effect of thoracic aortic balloon occlusion during hemorrhagic shock on spinal cord and visceral organ damage

LETTER

Hippokratia 2016, 20(3):255

Demiropoulos F1, Papazoglou K1, Miliaras D2
1
5th Department of Surgery, 2Laboratory of Histology and Embryology, Medical Faculty, Aristotle University of Thessaloniki, Thessaloniki, Greece



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2tI7mM9
via IFTTT

Diffusion weighted MRI and spectroscopy in invasive carcinoma of the breast at 3Tesla. Correlation with dynamic contrast enhancement and pathologic findings.

192-IMG01.jpg

RESEARCH ARTICLE

Hippokratia 2016, 20(3):192-197

Boulogianni G1, Chryssogonidis I2, Drevelegas A1
1Diagnostic Radiology Department, Interbalkan Medical Center, 2Diagnostic Radiology Department, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2v4htyu
via IFTTT

Extranodal marginal zone B-cell lymphoma arising in chronic myeloid leukaemia successfully treated with tyrosine kinase inhibitor: a case report

241-IMG01.jpg

CASE REPORT

Hippokratia 2016, 20(3):241-243

Mihaylov G1, Varbanova V1, Stoeva V1, Dikov T2
1
Clinical Hematology Department, 2Hematopathology and Immunohematology Department, National Hematological Disease Hospital, Sofia, Bulgaria



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2v4p5kw
via IFTTT

Increased oxidative stress in diabetic nephropathy and its relationship with soluble Klotho levels

RESEARCH ARTICLE

Hippokratia 2016, 20(3):198-203

Inci A1, Olmaz R1, Sarı F2, Coban M1, Ellidag HY3, Sarıkaya M1
1Division of Nephrology, Internal Medicine, Antalya Training and Research Hospital, 2Division of Nephrology, Internal Medicine, Akdeniz University, Faculty of Medicine, 3Division of Biochemistry, Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2tIiN6s
via IFTTT

Metastatic tumors to the head and neck region: a fifteen-year-long retrospective study

LETTER

Hippokratia 2016, 20(3):253

Krasic D1, Trajkovic M1, Zivkovic N2
1
Department of Maxillofacial Surgery, 2Department of Pathology, Faculty of Medicine, University of Niš, Niš, Serbia



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2v4GOZf
via IFTTT

Long-term mortality and follow-up after carotid artery stenting

204-IMG01.jpg

RESEARCH ARTICLE

Hippokratia 2016, 20(3):204-208

Arif S, Wojtasik J, Dziewierz A, Bartuś K, Dudek D, Bartuś S
2nd Department of Cardiology and Cardiovascular Interventions, University Hospital, Krakow, Poland



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2tIbM5D
via IFTTT

Massive bleeding in cardiac surgery. Definitions, predictors and challenges

I79-IMG01.jpg

REVIEW ARTICLE

Hippokratia 2016, 20(3):179-186

Petrou A1, Tzimas P1, Siminelakis S2
1Department of Anesthesiology and Postoperative Intensive Care, 2Department of Cardiothoracic Surgery, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Hellas



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2v4vRGT
via IFTTT

Αναζήτηση αυτού του ιστολογίου

! # Ola via Alexandros G.Sfakianakis on Inoreader