When is a sentinel node biopsy indicated for patients with primary melanoma? An update of the ‘Australian guidelines for the management of cutaneous melanoma’

When is a sentinel node biopsy indicated for patients with primary melanoma? An update of the 'Australian guidelines for the management of cutaneous melanoma':

Abstract

A sentinel lymph node biopsy is a surgical staging procedure performed for patients with primary cutaneous melanoma who are clinically lymph-node negative to determine whether there is low volume nodal metastasis in the draining lymph node field. A systematic review was recently performed to update the Australian clinical practice guidelines for the diagnosis and management of melanoma, addressing the question, 'When is a sentinel lymph node biopsy indicated?' This article discusses the findings of the systematic review and the evidence base for the updated guidelines.

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://orlhealth.blogspot.com/2017/07/when-is-sentinel-node-biopsy-indicated.html
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Exposure to biologic therapies during conception and pregnancy: a systematic review

Exposure to biologic therapies during conception and pregnancy: a systematic review:

Summary

Biologic therapies are effective treatments for psoriasis and are often used in women of childbearing age. To evaluate the safety of biologic therapy in conception and/or pregnancy, we have performed a systematic review of Pubmed, MEDLINE, EMBASE and Cochrane databases for multivariable adjusted studies of women exposed to biologic therapy relevant to the treatment of psoriasis during conception and/or pregnancy. We identified four population-based cohort studies involving 1300 women exposed to TNF-α inhibitors (TNFi) 3 months prior to or during the first 3 months of pregnancy. These studies showed a trend towards drug-specific harm with TNFi exposure in women with different inflammatory diseases, with an increased risk of congenital malformations (3 studies; odds ratio [OR] range: 1.32–1.64) and pre-term birth (one study; OR: 1.69, 95% CI 1.10–2.60). This trend did not reach statistical significance in all studies; study heterogeneity, variation across comparator cohorts, inadequate adjustment for important confounding variables such as co-therapy, and an absence of a common constellation of malformations mean there is uncertainty about the causal role of TNFi. No studies specifically addressed the effect of TNFi exposure in psoriasis during conception and/or pregnancy, or of IL-17 and IL12/23 antagonists in any indication. When counselling women these findings must be balanced against the potential impact of untreated severe psoriasis on conception and/or pregnancy and maternal wellbeing; on-going pharmacovigilance via registries remains essential to address this evidence gap.

This article is protected by copyright. All rights reserved.

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://orlhealth.blogspot.com/2017/07/exposure-to-biologic-therapies-during.html
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Wound healing in epidermolysis bullosa

Wound healing in epidermolysis bullosa:

Abstract

Epidermolysis bullosa (EB) is a group of inherited diseases characterised by recurrent skin blistering due to impaired epidermal or dermo-epidermal adhesion. In some subtypes, damage to internal organs causes serious comorbidities, and an increased risk of early and aggressive squamous cell carcinoma (SCC) characterizes recessive dystrophic EB (RDEB). It is likely that EB will only be cured by mutation-correction interventions, but until that goal becomes a reality we need to pool and extend knowledge about wound management and other strategies to improve quality of life for people with EB.

This article is protected by copyright. All rights reserved.

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://orlhealth.blogspot.com/2017/07/wound-healing-in-epidermolysis-bullosa.html
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Considering the impact of pregnancy on the natural history of hidradenitis suppurativa

Considering the impact of pregnancy on the natural history of hidradenitis suppurativa:

Abstract

Hidradenitis suppurativa (HS) is a chronic and debilitating inflammatory skin disease that disproportionately affects women of childbearing age. Yet, little has been written about the impact of pregnancy on the natural history of HS. It has been postulated that apocrine-gland activity diminishes in pregnancy, accounting for symptom remission.

This article is protected by copyright. All rights reserved.

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Cutaneous Indeterminate Cell Histiocytosis of Donor Origin After Allogeneic Hematopoietic Stem-Cell Transplantation.

Cutaneous Indeterminate Cell Histiocytosis of Donor Origin After Allogeneic Hematopoietic Stem-Cell Transplantation.: Allogeneic hematopoietic stem-cell transplantation and solid-organ transplantation are associated with an increased risk of secondary neoplasms. Indeterminate cell histiocytosis (ICH) is a rare disease composed of so-called indeterminate cells, an alleged cutaneous dendritic cell subset displaying histological and some ultrastructural and immunophenotypic features of Langerhans cells but lacking Birbeck granules. We report a case of cutaneous ICH occurring after allogeneic hematopoietic stem-cell transplantation for a myelodysplastic syndrome in a 56-year-old man. Microsatellite analysis demonstrated that the neoplastic cells were derived from the donor's hematopoietic system. This case broadens the spectrum of complications after stem-cell transplantation and demonstrates that cutaneous ICH in the setting of myelodysplastic syndromes may have a nonrelated origin to dysplastic myeloid cells.

Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://orlhealth.blogspot.com/2017/07/cutaneous-indeterminate-cell_19.html
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Phytochemicals and Naturally Occurring Substances in the Chemoprevention of Skin Cancer

Phytochemicals and Naturally Occurring Substances in the Chemoprevention of Skin Cancer:

Abstract

Purpose of Review

Non-melanoma skin cancer outnumbers all other cancers combined by three to four-fold while melanoma is the fifth most common cancer overall, and the deadliest form of skin cancer. Despite treatment advancements in the past several decades, incidence continues to rise. Phytochemicals and other naturally occurring substances may provide sustainable chemopreventive solutions. The purpose of this study is to review the key findings from the literature and report on the level of evidence based on study design.

Recent Findings

A comprehensive PubMed search was completed from 1984 to present using keywords "skin cancer chemoprevention" alone and with "phytochemicals," "alternative," "essential oils," and "vitamins." This search demonstrated that the literature strongly endorses the role of naturally occurring substances in the context of skin cancer chemoprevention, however the literature is predominantly comprised of data based on in vitro and animal based models.

Summary

Prior to acceptance into mainstream practice, high quality prospective studies to evaluate the role of naturally occurring compounds in the context of skin cancer chemoprevention are indicated.

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://orlhealth.blogspot.com/2017/07/phytochemicals-and-naturally-occurring.html
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Risk of Cancer in Patients with Psoriasis on Biologic Therapies: A Systematic Review

Risk of Cancer in Patients with Psoriasis on Biologic Therapies: A Systematic Review:

Summary

Biologic therapies are highly effective in psoriasis, but have profound effects on innate and adaptive immune pathways that may negatively impact on cancer immunosurveillance mechanisms. To investigate the risk of cancer in psoriasis patients treated with biologic therapy we searched Medline, Embase, and the Cochrane Library (up to August 2016) for randomized control trials, prospective cohort studies and systematic reviews that reported cancer incidence in people exposed to biologic therapy for psoriasis compared to a control population. Eight prospective cohort studies met our inclusion criteria. All the evidence reviewed related to tumour necrosis factor inhibitors (TNFi) with the exception of one study on ustekinumab. An increased risk of non-melanoma skin cancer (NMSC), particularly squamous cell carcinoma, was reported with TNFi compared to both a general United States population and a rheumatoid arthritis population treated with TNFi. No evidence for increased risk of cancers (reported as all cancers, lymphoma, melanoma, prostate, colorectal and breast cancer) other than NMSC was identified. There were important limitations to the studies identified including choice of comparator arms, inadequate adjustment for confounding factors and failure to account for latency periods of cancer. There remains a need for ongoing pharmacovigilance in relation to cancer risk and biologic therapy; to determine whether the NMSC signal is specifically attributable to TNFi, further investigation is required using prospectively-collected data with adjustment for known NMSC risk factors. Systematic review registration number: PROSPERO; 2015:CRD42015017538.

This article is protected by copyright. All rights reserved.

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://orlhealth.blogspot.com/2017/07/risk-of-cancer-in-patients-with_40.html
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Barriers to using electronic evidence based literature in nursing practice: a systematised review

Abstract

Background

Nurses' use of electronic literature has remained limited.

Objectives

The aim of this study was to identify barriers concerning application of electronic literature on evidence based practice in nursing.

Methods

Six bibliographic databases were searched using the following keywords: challenges, barriers, obstacles, evidence based practice, EBP, information seeking, online databases, electronic literature, bibliographic databases and nurs*. Results were filtered to peer reviewed empirical studies, written in English or Persian and published from 2010 to 2017. Studies were selected based on specified inclusion criteria, and quality of the included studies was assessed. The approved articles (n = 21) were extracted and synthesised.

Discussion

There are different types of barriers in using electronic evidence based literature in nursing demonstrating the issue as a multi-faceted problem. Not having enough time to conduct a search was the first major barrier noted by almost 81% (n = 17) of the reviewed studies followed by lack of knowledge on searching skills (66%; n = 14) and access requirements (38%; n = 8).

Conclusions

There appears to be an important role for hospital management in providing nurses with enough time and access to online information while at work and also for health care librarians together with nursing leaders in providing the required training on using electronic evidence based literature.

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More Evidence for Carotenoid Antioxidants in Photoprotection More Evidence for Carotenoid Antioxidants in Photoprotection

Might lycopene and other carotenoids offer protection against photoageing and skin cancers caused by UV exposure?The British Journal of Dermatology (Source: Medscape Today Headlines)

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Gene Score for Recurrence Risk in ER-Positive Breast Cancer Gene Score for Recurrence Risk in ER-Positive Breast Cancer

Can this gene recurrence score help determine which patients with ER-positive breast cancer are good candidates for radiotherapy after adjuvant chemotherapy plus tamoxifen?Journal of the National Cancer Institute (Source: Medscape Today Headlines)

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Epigenetics and Oxidative Stress in Aging

Aging is a multifactorial process characterized by the progressive loss of physiological functions, leading to an increased vulnerability to age-associated diseases and finally to death. Several theories have been proposed to explain the nature of aging. One of the most known identifies the free radicals produced by the mitochondrial metabolism as the cause of cellular and DNA damage. However, there are also several evidences supporting that epigenetic modifications, such as DNA methylation, noncoding RNAs, and histone modifications, play a critical role in the molecular mechanism of aging. In this review, we explore the significance of these findings and argue how the interlinked effects of oxidative stress and epigenetics can explain the cause of age-related declines.

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Versatile distally based neurocutaneous saphenous flap in the era of microsurgery

Versatile distally based neurocutaneous saphenous flap in the era of microsurgery:

Abstract

Background

The reconstruction of soft tissue defects in the distal third of the leg and ankle joint remains a challenge for reconstructive surgeons. Presently, the distally based neurocutaneous flaps are the predominant surgical alternatives to free tissue transfer. In this article, we describe our experience with the distally based saphenous neurocutaneous flap for reconstructing soft tissue defects in this region.

Methods

A retrospective review of all patients who underwent reconstruction of the leg distal third and ankle joint at our department from January 1996 to June 2016 was carried out. Only patients who underwent reconstructive surgery for acute traumatic injuries were included. The fasciocutaneous pedicle was 3–4 cm wide, and the anatomical structures consisted of the superficial and deep fascia, saphenous nerve, greater saphenous vein and their accompanying vessels together with an islet of subcutaneous cellular tissue and skin. The size of skin islands ranged from 5–7 to 10–14 cm².

Results

A total of 170 patients (142 men and 28 women) were included in this study. The mean follow-up period was 3 months. All flaps survived with partial necrosis in three patients. Severe venous congestion occurred only in five patients. However, the flap was eventually salvaged after limb elevation and interrupted bloodletting. All donor sites were closed using split-skin grafting.

Conclusions

The reverse saphenous neurocutaneous flap proved to be a reliable and efficient method for reconstructing soft tissue defects in the distal third of the leg and ankle joint.

Level of Evidence: Level IV, therapeutic study

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Hering's Law in Congenital Ptosis: Evaluation of the Contralateral Response to Unilateral Congenital Ptosis Repair.

Hering's Law in Congenital Ptosis: Evaluation of the Contralateral Response to Unilateral Congenital Ptosis Repair.: Purpose: To determine the applicability and clinical relevance of Hering's law for the eyelids in cases of congenital ptosis.

Methods: A retrospective chart review and digital photograph analysis of patients who underwent unilateral congenital ptosis repair at a tertiary, university-based, Oculoplastics clinic was conducted. Pre- and postoperative eyelid height (marginal reflex distance), upper eyelid symmetry, and brow position were determined using ImageJ analysis software. Changes in these values, and the relationship between the change in ipsi- and contralateral eyelid heights and brow positions, were determined.

Results: In 51 patients, the mean change in contralateral upper eyelid position (marginal reflex distance) following unilateral repair was -0.5 mm with 29% (n = 15) demonstrating a greater than 1 mm contralateral descent. The contralateral brow position remained stable with a mean change of +0.1 mm. No significant differences were seen between the 15 patients who demonstrated a contralateral upper eyelid descent greater than 1 mm and the remainder of the cohort in terms of amblyopia rate (p = 0.71), mean preoperative marginal reflex distance (p = 0.14), mean change in ipsilateral marginal reflex distance (p = 0.32), mean change in contralateral brow position (p = 0.44), or mean postoperative upper eyelid asymmetry (1.3 mm vs. 1.2 mm). Overall, the mean upper eyelid asymmetry improved from 2.6 mm preoperatively to 1.2 mm postoperatively. None of the 51 patients underwent subsequent contralateral ptosis repair.

Conclusions: Hering's law for the eyelids applies to cases of congenital ptosis but has little clinical significance due to improved upper eyelid asymmetry following unilateral surgery.

(C) 2017 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://ift.tt/2vEEXrd
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Transcanalicular Diode Laser-Assisted Revision Surgery for Failed Dacryocystorhinostomy With or Without Distal or Common Canalicular Obstruction.

Transcanalicular Diode Laser-Assisted Revision Surgery for Failed Dacryocystorhinostomy With or Without Distal or Common Canalicular Obstruction.: Purpose: To report the outcomes of transcanalicular diode laser-assisted revision surgery for failed dacryocystorhinostomy with/without distal or common canalicular obstruction.

Methods: The medical records and recorded videos of consecutive transcanalicular diode laser-assisted revision surgeries performed for failed dacryocystorhinostomy between May 2011 and May 2015 were reviewed. Cases of unavailability of video and cases lost to follow up after surgery were excluded from the study. With respect to the level of obstruction, lacrimal drainage systems were divided into Group 1 (obstruction at the level of the ostium) and Group 2 (obstruction at the level of the distal or common canaliculus). Data associated with anatomical and functional success were analyzed.

Results: Revision dacryocystorhinostomy surgeries were performed on 68 patients during the study period. Transcanalicular diode laser-assisted revision surgeries were performed on 48 eyes of 39 patients. Mean follow-up period after revision surgery was 13.3 +/- 12.6 months. Overall, anatomical success rate was 83.3% (40/48) and functional success rate was 68.8% (33/48). Anatomical success rates and functional success rates in the 2 groups showed no significant difference (80.0% [24/30] vs. 86.7% [13/15], p = 0.699; 70.0% [21/30] vs. 66.7% [10/15], p = 1.000, respectively).

Conclusions: Transcanalicular diode laser-assisted revision surgery may be an alternative technique for failed dacryocystorhinostomy. Distal or common canalicular obstruction did not affect the outcomes of revision surgeries.

(C) 2017 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.

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Doctors' group offers ideas for easing cancer costs

The American Society of Clinical Oncology has some suggestions for easing patients' money woes. (Source: Health News - UPI.com)

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McCain's brain tumor is particularly aggressive type

Sen. John McCain's tumor is one of the most aggressive forms of brain cancer (Source: ABC News: Health)

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Low Rate of Cancer Recurrence for Nipple - Sparing Mastectomy

Research suggests that the cosmetically superior procedure comes with no added risk of recurrence (Source: The Doctors Lounge - Oncology)

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PD-L1 Testing in Lung Cancer

This video reviews the use of PD-L1 testing in selecting patients for frontline lung cancer treatment with pembrolizumab and examines which patients might not be appropriate for immunotherapy. (Source: CancerNetwork)

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Nerlynx Approved to Help Prevent Breast Cancer's Return

Title: Nerlynx Approved to Help Prevent Breast Cancer's ReturnCategory: Health NewsCreated: 7/18/2017 12:00:00 AMLast Editorial Review: 7/19/2017 12:00:00 AM (Source: MedicineNet Cancer General)

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Most Women Should Forgo Ovarian Cancer Screening: Panel

Title: Most Women Should Forgo Ovarian Cancer Screening: PanelCategory: Health NewsCreated: 7/18/2017 12:00:00 AMLast Editorial Review: 7/19/2017 12:00:00 AM (Source: MedicineNet Cancer General)

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Health Tip: Getting Too Much Sun?

Here's what it can do (Source: Cancercompass News: Other Cancer)

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Doctors' Group Offers Ideas for Easing Cancer Costs

New drugs routinely priced at $100,000 a year, ASCO says (Source: Cancercompass News: Other Cancer)

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'Nipple-Sparing' Mastectomies Don't Raise Odds of Cancer's Return: Study

Research suggests that the cosmetically superior procedure comes with no added risk (Source: Cancercompass News: Breast Cancer)

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How not to die: ‘ stupid cancer ’ community helps angry young people live

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

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Accuracy of Lymph Node Imaging in Prostate Cancer: A Prospective Cohort Study to Determine the Concordance Between Two Imaging Modalities, " Combidex " Magnetic Resonance Imaging (Nano MRI) and 68Ga-PSMA Positron Emission Tomography (PET)

Conditions:   Prostate Cancer;   Lymph Node Metastases Interventions:   Diagnostic Test: Ferumoxtran-10 enhanced MRI; MRI contrast agent;   Diagnostic Test: 68Ga PSMA PET-CT Sponsors:   Radboud University;   Astellas Pharma Inc;   Canisius-Wilhelmina Hospital;   Catharina Ziekenhuis Eindhoven Recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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HPV Self-Sampling for Cervical Cancer Screening Among Transgender Men and Transmasculine Individuals

Condition:   Cervical Cancer Screening Intervention:   Behavioral: HPV self-sampling Sponsor:   University of Miami Recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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Non-invasive Absolute Intracranial Pressure Measurement in Patients With Malignant Middle Cerebral Artery Infarction for Determination of Timing to Descompressive Craniectomy.

Condition:   Intracranial Pressure Increase Intervention:   Device: Medical Device Vittamed 205 Sponsors:   Kienzler Jenny;   Schweizer National Fond Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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Study Evaluating Nivolumab (Anti-PD-1 Antibody) Alone Versus Nivolumab Plus Ipilimumab (Anti-CTLA-4 Antibody) in Patients With Resectable and Potentially Resectable Hepatocellular Carcinoma (HCC) (CA209-956)

Conditions:   Malignant Neoplasms of Digestive Organs;   Hepatocellular Carcinoma Interventions:   Drug: Nivolumab;   Drug: Ipilimumab Sponsors:   M.D. Anderson Cancer Center;   Bristol-Myers Squibb Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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Distribution of Lymph Node Metastases in Esophageal Carcinoma

Conditions:   Esophageal Neoplasms;   Lymph Node Metastases Intervention:   Sponsor:   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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Very Low Carbohydrate Diet Effects to GPS, Serum Lactate and TNF Alpha on Colorectal Cancer

Conditions:   Diet Modification;   Colorectal Adenocarcinoma;   Systemic Inflammation;   TNF Alpha;   Lactate Intervention:   Other: Very Low Carbohydrate Diet Sponsor:   Dr. Soetomo General Hospital Not yet recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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Electroacupuncture for Postoperative Ileus After Laparoscopic Surgery for Mid and Low Rectal Cancer

Conditions:   Postoperative Ileus;   Rectal Cancer Interventions:   Procedure: Electroacupuncture;   Procedure: Sham Acupuncture Sponsor:   Chinese University of Hong Kong Recruiting - verified July 2017 (Source: ClinicalTrials.gov)

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What is glioblastoma, the brain cancer John McCain has been diagnosed with?

This is the kind of brain cancer that killed Sen. Ted Kennedy, CBS News chief medical correspondent Dr. Jon LaPook said (Source: Health News: CBSNews.com)

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5 questions about the brain cancer diagnosed in Sen. John McCain

Glioblastoma, the cancer with which Sen. John McCain (R-Ariz.) has been diagnosed, is a highly lethal malignancy that killed Sen. Edward Kennedy (D-Mass.) and Beau Biden, the son of former vice president Joseph Biden. Here is what you need to know: What is glioblastoma? Glioblastoma is an aggressive cancer that is the most common of all […]Related:Zion, the world's youngest double hand transplant recipient, can now swing a baseball batScientists plan to trick Zika-carrying mosquitoes into breeding themselves out of existenceUnapproved stem-cell treatments touted on federal database ClinicalTrials.gov, study says (Source: Washington Post: To Your Health)

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Sen. John McCain Diagnosed With Brain Cancer

Sen. John McCain of Arizona was diagnosed with a brain tumor. (Source: WebMD Health)

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Immunohistochemical expression of ER- α and PR in papillary thyroid carcinoma.

This study included 62 primary and six metastatic papillary thyroid carcinoma cases. Nineteen and 38.7% of primary PTC cases showed positive nuclear expression for ER and PR, respectively. Metastatic cases showed 66.7% positive ER expression and all were negative for PR. Oestrogen receptor expression showed significant higher positivity in metastatic compared to primary PTC (p = 0.02) and it was significantly associated with primary PTC associated with thyroiditis (p = .002). Progesterone receptor expression was significantly associated with old age in primary PTC (p = .003) and it showed significant coparallel expression with ER (p = .000). Oestrogen and progesterone receptors expressed in papillary thyroid carcinoma opening the door for further studies to verify if those patients could b...

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Brain imaging before primary lung cancer resection: a controversial topic.

CONCLUSION: The rate of brain metastases identified in this study was similar to previous studies. This would suggest that preoperative staging of the central nervous system may change the management pathway in a small group of patients. However, for this group of patients, the change would be significant either sparing them non-curative surgery or allowing aggressive management of oligometastatic disease. Therefore, we would recommend pre-operative brain imaging with MRI for all patients undergoing potentially curative lung resection. PMID: 28717395 [PubMed] (Source: Ecancermedicalscience)

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Intraoperative radiotherapy: review of techniques and results.

This article aims to provide a review of the rationale, techniques, and outcomes for IORT across different sites relevant to current clinical practice. PMID: 28717396 [PubMed] (Source: Ecancermedicalscience)

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Regulation of fetal male germ cell development by members of the TGF β superfamily

Publication date: Available online 19 July 2017 Source:Stem Cell Research Author(s): Cassy Spiller, Guillaume Burnet, Josephine Bowles There is now substantial evidence that members of the transforming growth factor-β (TGFβ family) regulate germ cell development in the mouse fetal testis. Correct development of germ cells during fetal life is critical for establishment of effective spermatogenesis and for avoiding the formation of testicular germ cell cancer in later life. Here we consider the evidence for involvement of various TGFβ family members, attempt to reconcile discrepancies and clarify what we believe to be the likely in vivo roles of these factors. (Source: Stem Cell Research)

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'Housewife's luxurious Hamptons gala is all about finding a cure - Page Six

Page Six

'Housewife's luxurious Hamptons gala is all about finding a cure Page Six A routine check-up in 2013 revealed the thyroid cancer hadn't been cured, and, in fact, the disease had spread to his lungs. The reality star said she became angry that the treatment her 71-year-old husband had undergone, which works for many cancer ...

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What is glioblastoma, the brain cancer John McCain has been diagnosed with?

This is the kind of brain cancer that killed Sen. Ted Kennedy, CBS News chief medical correspondent Dr. Jon LaPook said (Source: Health News: CBSNews.com)

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5 questions about the brain cancer diagnosed in Sen. John McCain

Glioblastoma, the cancer with which Sen. John McCain (R-Ariz.) has been diagnosed, is a highly lethal malignancy that killed Sen. Edward Kennedy (D-Mass.) and Beau Biden, the son of former vice president Joseph Biden. Here is what you need to know: What is glioblastoma? Glioblastoma is an aggressive cancer that is the most common of all […]Related:Zion, the world's youngest double hand transplant recipient, can now swing a baseball batScientists plan to trick Zika-carrying mosquitoes into breeding themselves out of existenceUnapproved stem-cell treatments touted on federal database ClinicalTrials.gov, study says (Source: Washington Post: To Your Health)

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Sen. John McCain Diagnosed With Brain Cancer

Sen. John McCain of Arizona was diagnosed with a brain tumor. (Source: WebMD Health)

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Teens drink less if they know alcohol causes cancer — but most don't — Adelaide University and SAHMRI study finds - The Advertiser

The Advertiser

Teens drink less if they know alcohol causes cancer — but most don't — Adelaide University and SAHMRI study finds The Advertiser Teens are less likely to drink if they know that alcohol is a major cause of cancer, but most are unaware of the link, a South Australian study has found. "We need to get the message through that what may be considered harmless fun actually has ... and more »

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Systematic review of patient-reported outcomes after revision endoscopic sinus surgery

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Sen. John McCain diagnosed with brain cancer

(Source: CNN.com - Health)

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Sen. John McCain diagnosed with aggressive type of brain cancer - Chicago Tribune

Chicago Tribune

Sen. John McCain diagnosed with aggressive type of brain cancer Chicago Tribune According to the American Brain Tumor Association, more than 12,000 people a year are diagnosed with glioblastoma, a particularly aggressive type of tumor. The American Cancer Society puts the five-year survival rate for patients over 55 at about 4 ... Doctors: Sen. John McCain diagnosed with aggressive brain cancerLincoln Journal Star Sen. John McCain diagnosed with brain cancerkgw.com all 69 news articles »

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Sen. John McCain diagnosed with brain cancer

(Source: CNN.com - Health)

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Fat-free mass depletion in patients with COPD in Brazil: development of a new cutoff point and its relation with mortality and extrapulmonary manifestations

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Effects of procedure, upright equilibrium time, sex and BMI on the precision of body fluid measurements using bioelectrical impedance analysis

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Therapeutic lifestyle change diet enriched in legumes reduces oxidative stress in overweight type 2 diabetic patients: a crossover randomised clinical trial

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Results of Screening in Familial Non-Medullary Thyroid Cancer

Thyroid , Vol. 0, No. 0.


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[The 8th edition of the AJCC Cancer Staging Manual : Updates in otorhinolaryngology, head and neck surgery].

CONCLUSION: The new classification is a challenge for all specialties involved in tumor staging and therapy. The advantage for the patient lies in a more accurately adjustable treatment modality through more precise classification of tumors. Good collaboration and rapid implementation of the new classification is required in all disciplines involved in head neck tumor diagnostics and therapy. PMID: 28717958 [PubMed - as supplied by publisher] (Source: HNO)

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Hyperthermia-enhanced targeted drug delivery using magnetic resonance-guided focussed ultrasound: a pre-clinical study in a genetic model of pancreatic cancer.

CONCLUSION: This study demonstrates that HIFU-induced hyperthermia in combination with LTSL-Dox can be a non-invasive and effective method in enhancing the localised delivery and penetration of doxorubicin into pancreatic tumours. PMID: 28715967 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)

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Direct ‐Acting Antivirals and Recurrence of Hepatocellular Carcinoma

(Source: Liver Transplantation)

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Risk of secondary malignancies after radiation therapy for breast cancer: Comprehensive results.

CONCLUSION: There was an increased risk of secondary malignancies for breast cancer patients both with and without radiation therapy compared to the general population. There was an increased risk in specific sites for patients treated with radiation therapy. This risk was most evident in young patients and who had longer latency periods. PMID: 28719811 [PubMed - as supplied by publisher] (Source: Breast)

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'Flip or Flop' contractor Frank 'the Tank' rushed to hospital amid cancer battle - AOL

AOL

'Flip or Flop' contractor Frank 'the Tank' rushed to hospital amid cancer battle AOL Cancer has been an unsettlingly large presence among the "Flip or Flop" team in recent years. Tarek El Moussa was diagnosed with thyroid cancer after a registered nurse emailed the show's production company in 2013 to suggest that El Moussa get a ...

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Former US Presidential candidate and war hero John McCain diagnosed with brain cancer - Express.co.uk

Express.co.uk

Former US Presidential candidate and war hero John McCain diagnosed with brain cancer Express.co.uk Barack Obama tweeted: "John McCain is an American hero & one of the bravest fighters I've ever known. Cancer doesn't know what it's up against. Give it hell, John." Hillary Clinton tweeted: "John McCain is as tough as they come. Thinking of John, Cindy ... and more »

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Cytological study of DNA content and nuclear morphometric analysis for aid in the diagnosis of high-grade dysplasia within oral leukoplakia

Publication date: Available online 18 July 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Xi Yang, Xuan Xiao, Wenyan Wu, Xuemin Shen, Zengtong Zhou, Wei Liu, Linjun Shi
ObjectiveTo quantitatively examine the DNA content and nuclear morphometric status of oral leukoplakia (OL) and investigate its association with the degree of dysplasia in a cytologic study.Study DesignOral cytobrush biopsy was carried out to obtain exfoliative epithelial cells from lesions before scalpel biopsy at the same location in a blinded series of 70 patients with OL. Analysis of nuclear morphometry and DNA content status using image cytometry was performed with oral smears stained with the Feulgen-thionin method.ResultsNuclear morphometric analysis revealed significant differences in DNA content amount, DNA index, nuclear area, nuclear radius, nuclear intensity, sphericity, entropy, and fractal dimension (all P < .01) between low-grade and high-grade dysplasia. DNA content analysis identified 34 patients with OL (48.6%) with DNA content abnormality. Nonhomogeneous lesion (P = .018) and high-grade dysplasia (P = .008) were significantly associated with abnormal DNA content. Importantly, the positive correlation between the degree of oral dysplasia and DNA content status was significant (P = .004, correlation coefficient = 0.342).ConclusionCytology analysis of DNA content and nuclear morphometric status using image cytometry may support their use as a screening and monitoring tool for OL progression.



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Prenatal antidepressant use and risk of autism

Although the causes of autism spectrum disorder are largely unknown, among the first clues were observations of greater than expected aggregation of psychiatric disorders in families of children with...

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Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials

Objective To synthesise the evidence on the overall and differential effects of interventions based on diet and physical activity during pregnancy, primarily on gestational weight gain and maternal...

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Pediatric primary Sjögren syndrome presenting with bilateral ranulas: A case report and systematic review of the literature

Primary Sjögren syndrome is uncommon in children, and the standard clinical criteria used in diagnosis of adult Sjögren syndrome will miss many children with the disease. Floor of mouth ranulas have not been described in Sjögren syndrome.

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The risk ratio for development of hereditary sensorineural hearing loss in consanguineous marriage offspring

This study aims to define the relative risk of development of hearing loss in offspring of consanguineous marriages.

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Prenatal antidepressant use and risk of autism

Although the causes of autism spectrum disorder are largely unknown, among the first clues were observations of greater than expected aggregation of psychiatric disorders in families of children with...

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Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials

Objective To synthesise the evidence on the overall and differential effects of interventions based on diet and physical activity during pregnancy, primarily on gestational weight gain and maternal...

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Is Intra-Articular Steroid Injection to the Temporomandibular Joint for Juvenile Idiopathic Arthritis More Effective and Efficient When Performed With Image Guidance?

Related Articles

Is Intra-Articular Steroid Injection to the Temporomandibular Joint for Juvenile Idiopathic Arthritis More Effective and Efficient When Performed With Image Guidance?

J Oral Maxillofac Surg. 2017 Apr;75(4):694-700

Authors: Resnick CM, Vakilian PM, Kaban LB, Peacock ZS

Abstract
PURPOSE: To compare short-term outcomes and procedure times for intra-articular steroid injection (IASI) to the temporomandibular joint (TMJ) with and without the use of intraoperative image guidance for patients with juvenile idiopathic arthritis (JIA).
MATERIALS AND METHODS: This is a retrospective study of children with JIA who underwent TMJ IASI at Boston Children's Hospital (Boston, MA). Patients were divided into groups according to IASI technique: 1) "landmark" group if performed by an oral and maxillofacial surgeon using an anatomic landmark technique with no intraoperative image guidance or 2) "image-guided" group if performed by an interventional radiologist using intraoperative ultrasound and computed tomography. Predictor variables included IASI technique (landmark vs image guided), age, gender, JIA subtype, category of medications for arthritis, and presence of family history of autoimmune disease. Outcome variables were changes in patient-reported pain, maximal incisal opening (MIO), synovial enhancement ratio (ER), and total procedure time.
RESULTS: Forty-five patients with 71 injected TMJs were included. Twenty-two patients with 36 injected TMJs were in the landmark group and 23 patients with 35 injected joints were in the image-guided group. There were no relevant differences in age, gender, family history of rheumatologic disease, or disease subtype between groups. There were no differences in resolution of pain (P = 1.00), increase in MIO (P = .975), or decrease in ER (P = .492) between groups, but procedure times averaged 49 minutes longer for the image-guided group (P < .008).
CONCLUSIONS: There were no statistical differences in short-term outcomes, but procedure times were longer for the image-guided group. Although specific indications for the use of image guidance might exist, routine use of this procedure cannot be justified.

PMID: 28718441 [PubMed - in process]

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Detection of cancer biomarker protein on modified cellulose paper by fluorescence using aptamer-linked quantum dots

Analyst, 2017, Accepted Manuscript DOI: 10.1039/C7AN00624A, CommunicationPradip Das, Ulrich J. Krull Development of point-of-care bioassays for sensitive screening of protein-based cancer biomarkers would improve opportunity for early stage diagnosis. A strategy for a fluorescence resonance energy transfer (FRET)-based bioassay has been... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)

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An Ursolic Acid Derived Small Molecule Triggers Cancer Cell Death through Hyperstimulation of Macropinocytosis

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.7b00592 (Source: Journal of Medicinal Chemistry)

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Sensitive Electrochemical Detection of Nitric Oxide Release from Cardiac and Cancer Cells via a Hierarchical Nanoporous Gold Microelectrode

Analytical ChemistryDOI: 10.1021/acs.analchem.7b01430 (Source: Analytical Chemistry)

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Sen. John McCain diagnosed with brain cancer

McCain, 80, recently removed blood clot from above left eye; doctors then found a primary brain tumor, statement said Wednesday (Source: Health News: CBSNews.com)

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Differences in clinical characteristics and prognosis of sudden low- and high-frequency hearing loss.

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Differences in clinical characteristics and prognosis of sudden low- and high-frequency hearing loss.

Laryngoscope. 2017 Aug;127(8):1878-1884

Authors: Choo OS, Yang SM, Park HY, Lee JB, Jang JH, Choi SJ, Choung YH

Abstract
OBJECTIVES/HYPOTHESIS: We compared the clinical characteristics between acute low- and high-frequency hearing loss (LF and HF, respectively) patients, and the efficacy of three different treatment protocols (systemic steroids, intratympanic steroid injection, and combination therapy).
STUDY DESIGN: Prospective, randomized controlled study.
METHODS: A total of 111 patients diagnosed with LF or HF were treated on an outpatient basis. Each group was randomly divided into three equal subgroups based on therapy: oral steroid, intratympanic dexamethasone injection (IT), and combination therapy. Hearing gain was estimated by comparing pre- and post-treatment pure-tone averages. Recovery rate was assessed by Clinical Practice Guideline: Sudden Hearing Loss from the American Academy of Otolaryngology-Head and Neck Surgery.
RESULTS: In comparison of chief complaints, ear fullness and hearing loss were more common in the LF and HF group, respectively (P = .033 and P = .001, respectively). Hearing recovery rates were significantly different between the two groups (i.e., 74.1% [40/54] in the LF group and 45.6% [26/57] in the HF group; P < .001). Oral steroid therapy was most effective in the LF group (P = .017). In the HF group, all three modalities showed similar results, although IT tended to be the most effective (P = .390).
CONCLUSIONS: There were differences in chief complaints and treatment responses between LF and HF patients. Although they showed similar partial damage in the cochlea, the pathophysiology of LF and HF may be quite different.
LEVEL OF EVIDENCE: 1b. Laryngoscope, 127:1878-1884, 2017.

PMID: 28719039 [PubMed - in process]

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Identification of new tumor suppressor genes in triple-negative breast cancer

Although genomic sequencing has provided a better understating of the genetic landmarks in triple-negative breast cancer (TNBC), functional validation of candidate cancer genes (CCG) remains unsolved. In this study, we used a transposon mutagenesis strategy based on a two-step Sleeping Beauty (SB) forward genetic screen to identify and validate new tumor suppressors (TS) in this disease. We generated 120 siRNAs targeting 40 SB-identified candidate breast cancer TS genes and used them to downregulate expression of these genes in four human TNBC cell lines. Among CCG whose SB-mediated genetic mutation resulted in increased cellular proliferation in all cell lines tested, the genes ADNP, AP2B1, TOMM70A and ZNF326 showed tumor suppressor (TS) activity in tumor xenograft studies. Subsequent studies showed that ZNF326 regulated expression of multiple EMT and cancer stem cell (CSC) pathway genes. It also modulated expression of TS genes involved in the regulation of migration and cellular invasion and was a direct transcriptional activator of genes that regulate CSC self-renewal. ZNF326 expression associated with TNBC patient survival, with ZNF326 protein levels showing a marked reduction in TNBC. Our validation of several new tumor suppressor genes in TNBC demonstrate the utility of two-step forward genetic screens in mice, and offer an invaluable tool to identify novel candidate therapeutic pathways and targets.

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John McCain diagnosed with brain cancer - Washington Times

Washington Times

John McCain diagnosed with brain cancer Washington Times John McCain of Arizona, the influential Republican who has clashed with presidents of both parties over national security and foreign policy, has been diagnosed with brain cancer, his office said in a statement Wednesday night. The cancer was ... John McCain diagnosed with brain tumorChicago Tribune Sen. John McCain of Arizona has brain cancerOregonLive.com Doctors: Sen. John McCain has brain tumorSeacoastonline.com Chicago Sun-Times -The Globe and Mail all 559 news articles »

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Genetic syndrome needs more attention, terminally ill father says - The Press

The Press

Genetic syndrome needs more attention, terminally ill father says The Press A father given a life sentence by a genetic disorder believes more people need to know about the condition affecting him and his family. Jack Davis, 49, has been battling several cancers since his initial diagnosis of tongue and throat cancer in 2013 ...

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Unusual presentation of primary cutaneous follicle centre B-cell Lymphoma (PC-FCL) of the nose.

Related Articles

Unusual presentation of primary cutaneous follicle centre B-cell Lymphoma (PC-FCL) of the nose.

J Plast Reconstr Aesthet Surg. 2017 Jul 10;:

Authors: Maruccia M, Di Taranto G, Ruggieri M, Vestita M, Soda G, Giudice G

PMID: 28716696 [PubMed - as supplied by publisher]

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"Isolated long thoracic nerve palsy": More than meets the eye.

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"Isolated long thoracic nerve palsy": More than meets the eye.

J Plast Reconstr Aesthet Surg. 2017 Jun 27;:

Authors: Maldonado AA, Zuckerman SL, Howe BM, Mauermann ML, Spinner RJ

Abstract
INTRODUCTION: Two main hypotheses have been proposed for the pathophysiology of long thoracic nerve (LTN) palsy: nerve compression and nerve inflammation. We hypothesized that critical reinterpretation of electrodiagnostic (EDX) studies and MRIs of patients with a diagnosis of non-traumatic isolated LTN palsy could provide insight into the pathophysiology and, potentially, the treatment.
MATERIAL AND METHODS: A retrospective review was performed of all patients with a diagnosis of non-traumatic isolated LTN palsy and an EDX and brachial plexus or shoulder MRI studies performed at our institution. The original EDX studies and MR examinations were reinterpreted by a neuromuscular neurologist and musculoskeletal radiologist, respectively, both blinded to our hypothesis.
RESULTS: Seven patients met the inclusion criteria as having a non-traumatic isolated LTN palsy. Upon reinterpretation, all of them were found to have findings not consistent with an isolated LTN. On physical examination, three of them (43%) presented with weakness in muscles not innervated by the LTN. Four of them (57%) had additional EDX abnormalities beyond the distribution of the LTN. Five of them (71%) had MRI evidence of enlargement of nerves or denervation atrophy of muscles outside the innervation of the LNT, without evidence of compression of the LTN in the middle scalene muscle.
CONCLUSION: In our series, all 7 patients, originally diagnosed as having an isolated LTN, on reinterpretation, were found to have a more diffuse muscle/nerve involvement pattern, without MR findings to suggest nerve compression. These data strongly support an inflammatory pathophysiology.

PMID: 28716694 [PubMed - as supplied by publisher]

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Prospective Cohort Study Depending on the Use of Palliative Care for Advanced Stage of Cancer Patients

Conditions:   Stage IV Breast Cancer;   Stage IV Pancreatic Cancer;   Stage IV Colon Cancer;   Stage IV Gastric Cancer;   Stage IV Lung Cancer;   Stage IV Liver Cancer;   Malignant Hematologic Neoplasm;   Biliary Cancer Metastatic;   Pediatric Leukemia;   Pediatric Lymphoma;   Pediatric Brain Tumor;   Pediatric Solid Tumor Interventions:   Behavioral: Early palliative care;   Behavioral: Routine hospice care Sponsors:   Seoul National University Hospital;   Seoul National University Bundang Hospital;   National Cancer Center, Korea;   Kyunghee University Medical Center;   Severance Hospital;   Gyeongsang National University Hospital;   Chungnam National University Hospital;   Chonbuk  National University Hospita...

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No significant impact of prior treatment profile with docetaxel on the efficacy of cabazitaxel in Japanese patients with metastatic castration-resistant prostate cancer.

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No significant impact of prior treatment profile with docetaxel on the efficacy of cabazitaxel in Japanese patients with metastatic castration-resistant prostate cancer.

Med Oncol. 2017 Aug;34(8):141

Authors: Miyake H, Sugiyama T, Aki R, Matsushita Y, Tamura K, Motoyama D, Ito T, Otsuka A

Abstract
The objective of this study was to retrospectively analyze the oncological outcomes of Japanese patients with metastatic castration-resistant prostate cancer (mCRPC) who received cabazitaxel. This study included a total of 63 consecutive Japanese mCRPC patients treated with cabazitaxel following the failure of docetaxel, and assessed the prognostic significance of cabazitaxel therapy in these patients focusing on the association of efficacies between two taxane agents. After treatment with cabazitaxel (median 5 cycles), prostate-specific antigen (PSA) decline was observed in 39 patients (61.9%), including 13 (27.0%) achieving the response defined by PSA decline ≥50%. The median progression-free survival (PFS) and overall survival (OS) periods after the introduction of cabazitaxel were 4.1 and 14.8 months, respectively. The response rate to cabazitaxel was not significantly different between responders and non-responders to prior docetaxel, and there was no significant correlation between the PFSs with docetaxel and cabazitaxel. Furthermore, univariate analyses of several parameters identified the performance status (PS) and clinical symptoms, but not the cycles of docetaxel therapy, total amount of administered docetaxel or objective response to docetaxel therapy, as significant predictors of OS on cabazitaxel therapy, of which only PS was independently associated with OS on multivariate analysis. These findings suggest that oncological outcomes in Japanese mCRPC patients receiving cabazitaxel are generally satisfactory, irrespective of the profiles related to prior treatment with docetaxel, and that it might be preferable to introduce cabazitaxel to mCRPC patients with a good PS to maximize the prognostic benefit of this agent.

PMID: 28718092 [PubMed - in process]

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Sen. John McCain diagnosed with brain cancer

McCain, 80, recently removed blood clot from above left eye; doctors then found a primary brain tumor, statement said Wednesday (Source: Health News: CBSNews.com)

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The Science of Passionate Sex

How to have hot sex, according to science.

-- Read more on ScientificAmerican.com

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