MAKO Robotic Assisted Total Hip Replacement (THR) for Patients with Fused Hips

xlomafota13 shared this article with you from Inoreader MAKO Robotic Assisted Total Hip Replacement (THR) for Patients with Fused Hips Via The International Journal of Medical Robotics and Computer Assisted Surgery Abstract Background : Previous articles about MAKO robotic-assisted total hip replacement (THR) were mainly in patients with comparatively normal anatomy. Methods : From July 2020 to June 2021, we performed MAKO robotic-assisted THR in three hip-fused patients. We assessed the accuracy of prostheses implantation, collected clinical data, and discussed the value of this technique in this kind of patients. Result : All three patients achieved good leg length and prostheses position. A patient got femoral artery injury during the surgery. Moreover, she developed a thrombus. All three patients got acceptable Visual Analogue Scale (VAS) scores and function recovery six months later. Conclusion : MAKO robotic-assisted THR achieved excellent prosthesis position in hip fused patients. More cases are needed to confirm this advantage. The function recovery was acceptable. Caution should be paid to protect the surrounding abnormal arteries, especially in a limited surgical field. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

DNA methylation‐derived systemic inflammation indices and their association with oropharyngeal cancer risk and survival

xlomafota13 shared this article with you from Inoreader DNA methylation‐derived systemic inflammation indices and their association with oropharyngeal cancer risk and survival Via Head & Neck Cannot fetch mobilized content. Please try again later. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Lidocaine represses the malignant behavior of lung carcinoma cells via the circ_PDZD8/miR-516b-5p/GOLT1A axis

xlomafota13 shared this article with you from Inoreader Lidocaine represses the malignant behavior of lung carcinoma cells via the circ_PDZD8/miR-516b-5p/GOLT1A axis Via Cellular and Molecular Biology Histol Histopathol. 2022 Jan 21:18423. doi: 10.14670/HH-18-423. Online ahead of print. ABSTRACT Lung carcinoma is the most prevalent malignancy in adults. Lidocaine (Lido) has been confirmed to exert an anti-tumor role in many human cancers. However, the role and underlying mechanism of Lido in lung carcinoma remain poorly understood. Cell proliferation ability, migration, invasion, and apoptosis were measured by Colony formation, 5-ethynyl-2'-deoxyuridine (EdU), Cell Counting Kit-8 (CCK-8), transwell, and flow cytometry assays. Circ_PDZD8, microRNA-516b-5p (miR-516b-5p), and Golgi transport 1A (GOLT1A) levels were detected by real-time quantitative polymerase chain reaction (RT-qPCR). Protein levels of proliferating cell nuclear antigen (PCNA) and GOLT1A were examined by western blot assay. The binding relationship between miR-516b-5p and circ_PDZD8 or GOLT1A was predicted by circular RNA Interactome or Starbase 3.0 and then verified by a dual-luciferase reporter assay. The biological roles of circ_PDZD8 and Lido on lung carcinoma cell growth were examined by the xenograft tumor model in vivo. Lido suppressed proliferation, migration, invasion, and induced apoptosis in lung carcinoma cells. Circ_PDZD8 and GOLT1A were increased, miR-516b-5p was decreased in lung carcinoma tissues and cell lines. Their expression presented the opposite trend in Lido-triggered lung carcinoma cells. Circ_PDZD8 might overturn the repression of Lido on cell growth ability and metastasis in this tumor. Mechanically, circ_PDZD8 might regulate GOLT1A expression by sponging miR-516b-5p. Circ_PDZD8 weakened the anti-lung carcinoma effect of Lido in vivo. Circ_PDZD8 might mitigate the inhibitory effect of Lido on tumor cell malignancy by modulating the miR-516b-5p/GOLT1A axis, providing a novel insight for lung carcinoma treatment. PMID:35060113 | DOI:10.14670/HH-18-423 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Patient experience of diagnosis and management of spontaneous intracranial hypotension: a cross-sectional online survey

xlomafota13 shared this article with you from Inoreader Patient experience of diagnosis and management of spontaneous intracranial hypotension: a cross-sectional online survey Via leak of cerebrospinal fluid BMJ Open. 2022 Jan 20;12(1):e057438. doi: 10.1136/bmjopen-2021-057438. ABSTRACT OBJECTIVES: To present the results of a survey of patients with spontaneous intracranial hypotension (SIH) secondary to spinal cerebrospinal fluid (CSF) leak, documenting the patient experience of its diagnosis and management as well as quantifying its impact on quality of life. DESIGN: A cross-sectional anonymous online survey was designed in conjunction with the CSF Leak Association patient charity. The survey included questions on diagnosis, investigations and treatments received, as well as validated disability and quality of life questionnaires. PARTICIPANTS: Sixty-four patients with a confirmed diagnosis of SIH who were receiving treatment within the UK were included in the analysis. The mean age was 42.8 years, 94% were female and 43 had ongoing symptoms of SIH. RESULTS: Patients who presented to their general practitioner with symptoms of SIH were seen an average three times before being referred to a specialist, and in just under half of patients, the diagnosis was not made by the first specialist they saw. There was variability in which investigations were performed and how urgently they were organised. The mean EuroQol (EQ-5D-5L) Visual Analogue Scale score was 36.4/100 and median Headache Impact Test-6 score was 68/78 (very severe impact). More than half of the respondents reported that they had to amend work duties due to SIH, more than a quarter reported that they had lost their job and two-thirds reported that their condition had affected their financial health. Only 23.4% of patients felt that they had received enough help and advice to manage their pain due to SIH. CONCLUSIONS: SIH is a highly disabling disorder, affecting multiple domains, including pain, mobility, activities of daily living, financial circumstances and employment. Diagnostic delay and misdiagnosis are common, and currently there is a lack of consistency in the investigation and management of SIH in the UK. PMID:35058269 | DOI:10.1136/bmjopen-2021-057438 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Aberrant origin of bilateral vertebral arteries associated with bovine aortic arch

xlomafota13 shared this article with you from Inoreader Aberrant origin of bilateral vertebral arteries associated with bovine aortic arch Via radiol anat Surg Radiol Anat. 2022 Jan 21. doi: 10.1007/s00276-021-02880-w. Online ahead of print. ABSTRACT PURPOSE: Variance of aortic arch branches are clinically significant as they are encountered in multiple endovascular treatments. The knowledge of different variants is crucial to perform successful vascular interventions. METHODS: We report a novel anatomical variant of aortic arch found on contrast-enhanced computed tomography scan during a workup of cervical lymphadenopat hy. RESULTS: The CT neck revealed a bovine aortic arch with an aberrant origin of bilateral vertebral arteries from the aortic arch. The right vertebral artery arose between the bovine trunk and the left subclavian artery, while the left vertebral artery was present distal to the left subclavian artery. CONCLUSION: This article sheds light on the potential clinical significance of these various types of aortic arch branches. Knowing the exact type of variant is particularly important in patient undergoing management involving carotid and surrounding vessels. PMID:35061096 | DOI:10.1007/s00276-021-02880-w< /a> View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

E-health, digitalization, or digital transformation: Impact on cancer supportive care

xlomafota13 shared this article with you from Inoreader E-health, digitalization, or digital transformation: Impact on cancer supportive care Via Association française pour l'étude du cancer Bull Cancer. 2022 Jan 18:S0007-4551(21)00421-5. doi: 10.1016/j.bulcan.2021.08.015. Online ahead of print. ABSTRACT The value of comprehensive oncology management including supportive care is well established, but it remains challenged by the increasing need and access disparities. By enabling real-time, dynamic, technology-assisted assessments and interventions, e-health is a key for optimizing supportive care in Oncology in 2021. Indeed, e-health has the potential to improve communication between the patient and the healthcare professional, improve the assessment and management of symptoms and toxicities, and optimize patient engagement across the continuum of care. We are witnessing a new era of patient-centered care, where the patient becomes an actor in his or her own care. In this review, we present the definitions and the French legal framework of e-health, and some currently available e-health solutions in oncology focused on su pportive care, including the issues of their validation and financing. We will also discuss the challenges and access for patients, as well as the issues of access, security and transfer of health data. PMID:35063184 | DOI:10.1016/j.bulcan.2021.08.015 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

New European approval: Idecabtagene vicleucel in relapsed and/or refractory myeloma after at least 3 lines of treatment

xlomafota13 shared this article with you from Inoreader New European approval: Idecabtagene vicleucel in relapsed and/or refractory myeloma after at least 3 lines of treatment Via Association française pour l'étude du cancer Bull Cancer. 2022 Jan 18:S0007-4551(21)00686-X. doi: 10.1016/j.bulcan.2021.10.007. Online ahead of print. NO ABSTRACT PMID:35063182 | DOI:10.1016/j.bulcan.2021.10.007 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Exploration of chest wall perforator vascular anatomy on standard breast MRI: A potential aid to chest wall perforator flap planning

xlomafota13 shared this article with you from Inoreader Exploration of chest wall perforator vascular anatomy on standard breast MRI: A potential aid to chest wall perforator flap planning Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Dec 1:S1748-6815(21)00639-2. doi: 10.1016/j.bjps.2021.11.092. Online ahead of print. ABSTRACT Local chest wall perforator flaps (CWPFs) are a volume replacement technique permitting breast-conserving surgery in patients who otherwise may require a mastectomy. These flaps are based on one or more perforating arteries arising from the lateral chest wall that travel through the soft tissue and into the sub-dermal plexus to perfuse the flap. Examples include the lateral intercostal and lateral thoracic artery perforators (LICAP and LTAP, respectively). Cross-sectional imaging of perforating vessels is not routinely performed, and vessels are mapped pre- and peri-operatively using a hand-held acoustic doppler device. As many breast cancer patients undergo pre-operative MRI scanning for oncological purposes, we investigated the role of MRI in mapping the vascular anatomy to aid with the surgical planning o f CWPFs. We collated data retrospectively on a cohort of breast cancer patients who underwent breast MRI as part of routine pre-operative imaging. Axial 3D high-resolution dynamic contrast-enhanced MRI sequences with multiplanar reconstructions were analysed by a consultant radiologist. The presence and calibre of lateral chest wall perforator vessels were assessed. Fifty patients were suitable for inclusion. A consistent pattern of lateral chest wall vasculature was observed. Forty-eight patients (96%) demonstrated a bilateral lateral thoracic artery (LTA) descending inferiorly along the chest wall with two-thirds of these communicating with perforating intercostal vessels. True independent LICAP vessels were identified in six patients. From our observations, lateral CWPFs are dependent on an intricate intercommunication between intercostal vessels and the LTA which in turn supply perforators to the lateral chest wall donor site. PMID:35063384 | DOI:10.1016/j.bjps.2021.11.092 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The management and outcome of large volume liposarcomas encasing the sciatic nerve

xlomafota13 shared this article with you from Inoreader The management and outcome of large volume liposarcomas encasing the sciatic nerve Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Oct 22:S1748-6815(21)00505-2. doi: 10.1016/j.bjps.2021.09.070. Online ahead of print. ABSTRACT This paper outlines the oncological outcomes of patients with large volume liposarcomas of the posterior thigh who underwent nerve-preserving surgery utilising epineural dissection. Thirty-seven consecutive patients (group I) with a mean age of 66.2 (31-96) were surgically treated with a planned marginal resection and epineurectomy for liposarcoma with known sciatic nerve involvement between March 1997 and January 2015. The mean follow-up was 79 months (15-192). All patients underwent multidisciplinary team (MDT) pre-operative assessment and staging, with follow-up in Sarcoma Clinic. Pre-operative function was assessed by applying the Toronto extremity salvage score (TESS). Oncological and functional outcomes were recorded. In grades 1, 2, and 3, 24, 6, and 7 liposarcomas, respectively, were included with m ean volume 1859 cm3. Sciatic nerve involvement extended for 13-30 cm; in one case, the nerve was abutting the tumour throughout its length. Soft tissue reconstructive surgery was required in three cases. The remainder underwent direct primary closure. Seventeen patients underwent post-operative adjuvant radiotherapy 46-60 Gy and three received chemotherapy. There was local recurrence of disease in three patients. One patient had post-radiation wound breakdown treated non-operatively. Three patients died of an unrelated cause. When compared to a cohort of 37 patients without sciatic nerve involvement (group II), there were no significant differences in local and systemic recurrence rate or post-operative survival. In conclusion, sciatic nerve-preserving surgery is both possible and safe when using a planned epineural dissection in large volume tumours encasing the sciatic nerve. PMID:35063385 | DOI:10.1016/j.bjps.2021.09.070 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Towards decoding selective attention through cochlear implant electrodes as sensors in subjects with contralateral acoustic hearing

xlomafota13 shared this article with you from Inoreader Towards decoding selective attention through cochlear implant electrodes as sensors in subjects with contralateral acoustic hearing Via cortical auditory J Neural Eng. 2022 Jan 21. doi: 10.1088/1741-2552/ac4de6. Online ahead of print. ABSTRACT OBJECTIVES: Focusing attention on one speaker in a situation with multiple background speakers or noise is referred to as auditory selective attention. Decoding selective attention is an interesting line of research with respect to future brain-guided hearing aids or cochlear implants (CIs) that are designed to adaptively adjust sound processing through cortical feedback loops. This study investigates the feasibility of using the electrodes and backward telemetry of a CI to record electroencephalography (EEG). APPROACH: The study population included 6 normal-hearing (NH) listeners and 5 CI users with contralateral acoustic hearing. Cortical auditory evoked potentials (CAEP) and selective attention were recorded using a state-of-the-art high-density scalp EEG and, in the case of CI users, also using two CI electrodes as sensors in combination with t he backward telemetry system of these devices (iEEG). MAIN RESULTS: In the selective attention paradigm with multi-channel scalp EEG the mean decoding accuracy across subjects was 94.8 % and 94.6 % for NH listeners and CI users, respectively. With single-channel scalp EEG the accuracy dropped but was above chance level in 8 to 9 out of 11 subjects, depending on the electrode montage. With the single-channel iEEG, the selective attention decoding accuracy could only be analyzed in 2 out of 5 CI users due to a loss of data in the other 3 subjects. In these 2 CI users, the selective attention decoding accuracy was above chance level. SIGNIFICANCE: This study shows that single-channel EEG is suitable for auditory selective attention decoding, even though it reduces the decoding quality compared to a multi-channel approach. CI-based iEEG can be used for the purpose of recording CAEPs and decoding selective attention. However, the study also points out the need for further tec hnical development for the CI backward telemetry regarding long-term recordings and the optimal sensor positions. PMID:35062007 | DOI:10.1088/1741-2552/ac4de6 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cuneiform (cuniculatum) variant of oral squamous cell carcinoma revisited: Presentation of two cases and literature review of a rare entity

xlomafota13 shared this article with you from Inoreader Cuneiform (cuniculatum) variant of oral squamous cell carcinoma revisited: Presentation of two cases and literature review of a rare entity Via Head & Neck Abstract Background Oral carcinoma cuniculatum (OCC) is a rare, locally aggressive tumor, which tends to invade underlying bone. We present two cases of OCC, one demonstrating invasion of the mandible and the other limited to the tongue. Methods An 87-year-old male presented with a right-sided buccogingival lesion. Biopsy results led to a diagnosis of verrucous hyperplasia, which was later revised to OCC. Additionally, a 94-year-old female presented with a left lateral tongue lesion. A biopsy showed in-situ and invasive keratinizing squamous cell carcinoma that was later defined as a soft tissue OCC. Results Following surgical resection, the diagnosis of OCC was established in both patients. We provide a comprehensive literature review of OCC in the context of both case presentations. Conclusions OCC is a rare entity, which has a tendency to be misdiagnosed. We emphasize the importance of recognizing the common features of OCC in order to aid in accurate diagnosis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.