A Tissue Engineered Construct for Laryngeal Regeneration: A Proof‐of‐Concept Device Design Study

xlomafota13 shared this article with you from Inoreader A Tissue Engineered Construct for Laryngeal Regeneration: A Proof‐of‐Concept Device Design Study Via The Laryngoscope Objectives/Hypothesis Develop a patient-specific tissue engineered construct for laryngeal reconstruction following a partial laryngectomy. Study Design Bench and animal research. Methods A construct made from a porous polyethylene scaffold shaped in a canine-specific configuration and seeded with autologous canine adipose-derived stem cells in fibrin glue was implanted in a canine following a partial laryngectomy. After 1 year, the construct was first evaluated in vivo with high-speed imaging and acoustic–aerodynamic measures. It was then explanted and evaluated histologically. Results The canine study at 1 year revealed the construct provided voicing (barking) with acoustic and aerodynamic measures within normal ranges. The canine was able to eat and breathe normally without long-term support. The construct was integrated with epithelialization of all areas except the medial portion of the vocal fold structure. No anti-infective agents were needed after the standard perioperative medications were completed. Conclusion This study provided a successful first step toward developing a patient-specific composite construct for patients undergoing partial laryngectomies. Level of Evidence Not Applicable Laryngoscope, 2022 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Auditory Behavior in Adult-Blinded Mice

xlomafota13 shared this article with you from Inoreader Auditory Behavior in Adult-Blinded Mice Via Journal of the Association for Research in Otolaryngology Abstract Cross-modal plasticity occurs when the function of remaining senses is enhanced following deprivation or loss of a sensory modality. Auditory neural responses are enhanced in the auditory cortex, including increased sensitivity and frequency selectivity, following short-term visual deprivation in adult mice (Petrus et al. Neuron 81:664–673, 2014). Whether or not these visual deprivation–induced neural changes translate into improved auditory perception and performance remains unclear. As an initial investigation of the effects of adult visual deprivation on auditory behaviors, CBA/CaJ mice underwent binocular enucleation at 3–4 weeks old and were tested on a battery of learned behavioral tasks, acoustic startle response (ASR), and prepulse inhibition (PPI) tests beginning at least 2 weeks after the enucleation procedure. Auditory brain stem responses (ABRs) were also measured to screen for potential effects of visual deprivation on non-behavioral hearing function. Control and enucleated mice showed similar tone detection sensitivity and frequency discrimination in a conditioned lick suppression test. Both groups showed normal reactivity to sound as measured by ASR in a quiet background. However, when startle-eliciting stimuli were presented in noise, enucleated mice showed decreased ASR amplitude relative to controls. Control and enucleated mice displayed no significant differences in ASR habituation, PPI tests, or ABR thresholds, or wave morphology. Our findings suggest that while adult-onset visual deprivation induces cross-modal plasticity at the synaptic and circuit levels, it does not substantially influence simple auditory behavioral performance. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Therapeutic diminution of Interleukin-10 with intranasal theophylline administration in hyposmic patients

xlomafota13 shared this article with you from Inoreader Therapeutic diminution of Interleukin-10 with intranasal theophylline administration in hyposmic patients Via American Journal of Otolaryngology Publication date: Available online 28 January 2022 Source: American Journal of Otolaryngology Author(s): Whitney Hosein, Robert I. Henkin View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Spindle cell carcinoma of larynx: a report of 3 cases

xlomafota13 shared this article with you from Inoreader Spindle cell carcinoma of larynx: a report of 3 cases Via Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Jan 7;57(1):59-61. doi: 10.3760/cma.j.cn115330-20210304-00106. NO ABSTRACT PMID:35090213 | DOI:10.3760/cma.j.cn115330-20210304-00106 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Research progress of nasal mucosal epithelial cells in chronic rhinosinusitis

xlomafota13 shared this article with you from Inoreader Research progress of nasal mucosal epithelial cells in chronic rhinosinusitis Via Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Jan 7;57(1):78-81. doi: 10.3760/cma.j.cn115330-20210303-00103. NO ABSTRACT PMID:35090218 | DOI:10.3760/cma.j.cn115330-20210303-00103 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Place of Linacs in extracranial stereotactic radiotherapy: Are they now equivalent to Cyberknife®?

xlomafota13 shared this article with you from Inoreader Place of Linacs in extracranial stereotactic radiotherapy: Are they now equivalent to Cyberknife®? Via Association française pour l'étude du cancer Bull Cancer. 2022 Jan 25:S0007-4551(22)00003-0. doi: 10.1016/j.bulcan.2021.10.008. Online ahead of print. ABSTRACT Extracranial stereotactic radiotherapy has developed recently, since the years 1990-2000. Devices specifically dedicated to this type of treatment were then developed and shared the favors of radiation oncologists: Tomotherapy® and especially Cyberknife®, which offered the advantage of "tracking" with the possibility of real time motion correction, allowing an increase in the precision of targeting volumes. Recently, the latest generations of linear accelerators (Linac) have been developed, integrating much higher dose rates, an improved ballistic precision with a very short treatment duration time and the possibility of real time motion management (with notably the possibility of adaptive radiotherapy in real time with the development of "MLC tracking"). So are Linacs able to perform equivalent (not inferior) extracrani al stereotactic radiotherapy treatments to those with Cyberknife®, the historical gold standard in this field? This article presents a comparison of these two treatment devices, by successively considering dose distributions in the irradiated volume, distant received doses from this volume (including the "integral dose"), problems linked to the duration of the sessions and those linked to motion management. PMID:35090720 | DOI:10.1016/j.bulcan.2021.10.008 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Mediastinal basal pulmonary artery identification and classification by three-dimensional reconstruction

xlomafota13 shared this article with you from Inoreader Mediastinal basal pulmonary artery identification and classification by three-dimensional reconstruction Via radiol anat Surg Radiol Anat. 2022 Jan 29. doi: 10.1007/s00276-022-02889-9. Online ahead of print. ABSTRACT PURPOSE: The primary objective of the present study was to use CT angiography and 3D reconstruction to assess and to classify the mediastinal pulmonary basal segmental arteries. METHODS: We report a particular type of bifurcated left lower pulmonary artery, namely, the "mediastinal basal pulmonary artery" type, which is the first branch from the proximal the left pulmonary a rtery (LPA) between the left main bronchus (LMB) and the left superior pulmonary vein (LSPV) and proceeding directly into the lower lobe. There are many types of mediastinal basal pulmonary arteries, and these can be classified worldwide in a unified way and format, which will be beneficial for clinical records, annotation and academic exchange. RESULTS: The mediastinal basal pulmonary arteries are described either as "supernumerary" when duplicating or "displaced" when replacing the normal arterial branching pattern of the lower lobe. The displaced type is more frequent than the supernumerary type. There are 12 types of left mediastinal basilar arteries. CONCLUSION: This is the first report to categorize the mediastinal basal pulmonary artery, is the first to suggest a system for mediastinal basal pulmonary artery nomenclature, and creates simplified models for use when planning anatomical segmentectomy. Knowledge and recognition of this rare and special condition may f acilitate better diagnosis and treatment of these patients. PMID:35092478 | DOI:10.1007/s00276-022-02889-9 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Onset and resolution failure of recurrent benign paroxysmal positional vertigo: the role of cervical range of motion

xlomafota13 shared this article with you from Inoreader Onset and resolution failure of recurrent benign paroxysmal positional vertigo: the role of cervical range of motion Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Jan 29. doi: 10.1007/s00405-021-07226-1. Online ahead of print. ABSTRACT PURPOSE: To explore possible associations between cervical spine mobility, measured by cervical range of motion (CROM) and a possible earlier onset of recurrent benign paroxysmal positional vertigo (BPPV), as well as an increased failure rate of canalith repositioning procedures. METHODS: Medical records of 749 patients (247, 253 and 249 patients with a CROM ≤ 45°, between 45.1° and 55° and > 55.1°, respectively) with a first-time diagnosis of non-traumatic BPPV were included in this retrospective study. Age, gender, canal involvement and CROM values were treated as prospective prognostic factors for time of BPPV recurrence onset (RO) and number of manoeuvres needed to achieve resolution (resolution rate, RR). A multiple regression analysis was performed. RESULTS: A significant increase in the incidence of recur rent BPPV was found in patients with reduced CROM (139 [56.27%;], 102 [40.31%] and 87 [34.93%], respectively, belonging to ≤ 45°, 45.1°-55° and > 55.1° subgroups; X2 = 9.42, p = 0.008). A strong association between age, CROM and recurrent BPPV RO and RR was demonstrated, respectively (multiple correlation coefficients = 0.492678 and 0.593493, respectively, p value < 10-4). Canal involvement was in line with the previous experiences. CONCLUSION: The results from this retrospective analysis unveiled the previously unexplored relation between reduction in cervical spine mobility and BPPV recurrence and treatment failure. The data from this study do not indicate the mechanisms by which this comorbidity might directly cause recurrent BPPV. However, they may suggest CROM to be evaluated, in association with other known risk factors for increased susceptibility to BPPV recurrence. PMID:35091829 | DOI:10.1007/s00405-021-07226-1 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Bereavement Practices Among Head and Neck Cancer Surgeons

xlomafota13 shared this article with you from Inoreader Bereavement Practices Among Head and Neck Cancer Surgeons Via The Laryngoscope Objectives Head and neck cancer surgeons frequently interact with dying patients with advanced disease and their families, but little is known about their bereavement practices after a patient's death. The aim of this study is to elucidate the frequency of common bereavement practices, cited barriers to bereavement, and predictive physician factors that lead to an increase in bereavement practices among head and neck cancer surgeons. Methods A 20-item survey was sent to 827 active surgeons of the American Head and Neck Society. Approval was obtained and the survey was distributed through the American Head and Neck Society. Demographics, frequency of common bereavement practices, empathy, and barriers were assessed. Multiple linear regression was performed to determine physician factors associated with more frequent bereavement follow-up. Results There were 156 respondents (18.9% response rate). Overall, surgeons were more likely to usually/always call (48.5%) or send a letter (42.4%) compared with other practices such as attending funerals (0%), offering family meetings (18.6%), or referring family members to counseling (7.7%). Many barriers were cited as being at least somewhat important: being unaware about a patient's death (67.3%) was the most cited, whereas 51.3% cited a lack of mentorship/training in this area. Scoring higher on empathy questions (P ≤ .001) was associated with more frequent surgeon bereavement follow-up with the family of deceased patients. Conclusion There is substantial practice variation among surgeons suggesting a lack of consensus on their roles in bereavement follow-up. Having higher empathy was predictive of higher engagement. Level of Evidence NA Laryngoscope, 2022 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Diagnostic accuracy of conventional oral examination for detecting oral cavity cancer and potentially malignant disorders in patients with clinically evident oral lesions: Systematic review and meta‐analysis

xlomafota13 shared this article with you from Inoreader Diagnostic accuracy of conventional oral examination for detecting oral cavity cancer and potentially malignant disorders in patients with clinically evident oral lesions: Systematic review and meta‐analysis Via Head & Neck Abstract This systematic review evaluates the diagnostic accuracy of conventional oral examination (COE) versus incisional or excisional biopsy for the diagnosis of malignant and/or dysplastic lesions in patients with clinically evident lesions. Searches were conducted across five electronic databases from inception to January 2020. Meta-analyses were undertaken, where appropriate. Among 18 included studies, 14 studies were included in the meta-analysis, giving summary estimates for COE of 71% sensitivity and 85% specificity for the diagnosis of dysplastic and/or malignant lesions. The pooled diagnostic accuracy of identifying malignant-only lesions was reported in seven studies, giving a pooled estimate of 88% sensitivity and 81% specificity. Diagnostic accuracy of different types of dental/medical professionals in identifying dysplastic or malignant lesions gave varying estimates of sensitivity and specificity across three studies. Further research is needed to improve the diagnostic acc uracy of COE for early detection of dysplastic and malignant oral lesions. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.