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A robust and powerful two-step testing procedure for local ancestry adjusted allelic association analysis in admixed populations

ABSTRACTGenetic association studies in admixed populations allow us to gain deeper understanding of the genetic architecture of human diseases and traits. However, population stratification, complicated linkage disequilibrium (LD) patterns, and the complex interplay of allelic and ancestry effects on phenotypic traits pose challenges in such analyses. These issues may lead to detecting spurious associations and/or result in reduced statistical power. Fortunately, if handled appropriately, these same challenges provide unique opportunities for gene mapping. To address these challenges and to take these opportunities, we propose a robust and powerful two-step testing procedure Local Ancestry Adjusted Allelic (LAAA) association. In the first step, LAAA robustly captures associations due to allelic effect, ancestry effect, and interaction effect, allowing detection of effect heterogeneity across ancestral populations. In the second step, LAAA identifies the source of association, namely a…
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Methods for meta-analysis of multiple traits using GWAS summary statistics

ABSTRACTGenome-wide association studies (GWAS) for complex diseases have focused primarily on single-trait analyses for disease status and disease-related quantitative traits. For example, GWAS on risk factors for coronary artery disease analyze genetic associations of plasma lipids such as total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides (TGs) separately. However, traits are often correlated and a joint analysis may yield increased statistical power for association over multiple univariate analyses. Recently several multivariate methods have been proposed that require individual-level data. Here, we develop metaUSAT (where USAT is unified score-based association test), a novel unified association test of a single genetic variant with multiple traits that uses only summary statistics from existing GWAS. Although the existing methods either perform well when most correlated traits are affected by the genetic variant in the same direction or are powerful when only …

What is a calculus bridge?

SOMETIMES you need a phone call from your dentist to remind you to schedule a teeth-cleaning appointment. Other times, just running your tongue over your teeth may get you to pay a visit to the dentist.

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Patterson Companies, Inc. (PDCO) Stake Decreased by TD Asset Management Inc.

TD Asset Management Inc. lowered its holdings in Patterson Companies, Inc. by 32.4% in the 3rd quarter, according to its most recent Form 13F filing with the Securities and Exchange Commission . The fund owned 56,216 shares of the company's stock after selling 26,922 shares during the quarter.

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Effects of Rhodomyrtus tomentosa extract on virulence factors of Candida albicans and human neutrophil function

Publication date: Available online 10 December 2017
Source:Archives of Oral Biology
Author(s): Jutharat Hmoteh, Khadar Syed Musthafa, Supayang Piyawan Voravuthikunchai
Objective: Candida albicans has become a major problem of oral candidiasis due to increase in antibiotic resistance. Rhodomyrtus tomentosa, a medicinal plant possessing several phytochemical constituents, has been considered as a potential source of antimicrobial and immunomodulatory agents. The aim of this study was to investigate anti-virulence and immunostimulatory activity of R. tomentosa ethanolic leaf extract against C. albicans.MethodsThe effects of the extract on C. albicans were assessed on germ tube production, adherence of the organisms to surfaces, and biofilm. In addition, the effects of the extract on phagocytosis and killing activity of neutrophils against the pathogen were investigated.ResultsSuppression of germ tube production following 30min exposure to the extract at 256μg/mL was significantly incr…

Reliability of a new test food to assess masticatory function

Publication date: Available online 9 December 2017
Source:Archives of Oral Biology
Author(s): Laura Khoury-Ribas, Raul Ayuso-Montero, Bernat Rovira-Lastra, Maria Peraire, Jordi Martinez-Gomis.
ObjectiveThis study assessed the reliability and validity of masticatory function assessment using a new test food, Optozeta.DesignThirty-five adults participated in the cross-sectional clinical part of the study; ten of them performed a retest. They performed two free-style masticatory tests consisting of five trials of 20 cycles each chewing three pieces of Optosil or Optozeta placed in a latex bag. Optozeta was created by mixing 50% Optosil with 50% of Zetalabor. Masticatory performance, masticatory laterality and chewing rate were assessed. Reliability and construct validity were assessed using the intraclass correlation coefficient (ICC) and Spearman correlations, respectively.ResultsHigher ICC values were observed for each aspect of masticatory function as assessed using Optozeta compar…

Over 40 children received free dental care at MTC

MTC Students Kayla Green and Sergio Flores assist Dr. Maria Pardo, DDS at the "Project Smart Smiles" clinic at Manatee Technical College Friday Dec. 8, 2017. MTC Students Kayla Green and Sergio Flores assist Dr. Maria Pardo, DDS at the "Project Smart Smiles" clinic at Manatee Technical College Friday Dec. 8, 2017.

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Lawmakers push for licensing system for dental therapists

A bipartisan group of New Mexico lawmakers is seeking to expand dental care in rural areas by creating a new system of licensed dental workers. The Albuquerque Journal reports the legislators are seeking to establish dental therapists - a mid-level professional between a dentist and a hygienist.

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Smile, there's free dental care in Whitehorse this weekend

'All of our staff also wanted to do it, and we're happy to help,' said Sammy Hachem, co-owner of Riverstone Dental Clinic in Whitehorse. The clinic will offer free care on Saturday, to people with no dental insurance.

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Medication related osteonecrosis of the jaws associated with targeted therapy as monotherapy and in combination with antiresorptives. A report of 7 cases from the Copenhagen Cohort.

Related ArticlesMedication related osteonecrosis of the jaws associated with targeted therapy as monotherapy and in combination with antiresorptives. A report of 7 cases from the Copenhagen Cohort.Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Nov 06;:Authors: Abel Mahedi Mohamed H, Nielsen CEN, Schiodt MAbstract
OBJECTIVE: The aim of this study was to report cases of medication-related osteonecrosis of the jaws (MRONJ) associated with targeted therapy (TT) with or without concomitant antiresorptive treatment, among the Copenhagen ONJ cohort, which includes all consecutive cases of MRONJ seen in Copenhagen.
STUDY DESIGN: We retrospectively studied the treatment of 204 consecutive patients with MRONJ, seen between January 2010 and May 2016, to identify those associated with TT.
RESULTS: We detected 7 cases of MRONJ associated with TT (3.4%). Four patients received TT only, whereas 3 were concomitantly treated with bisphosphonates (n = 3) and/or denosumab (n = 3). The TT regimens i…

Consanguineous marriages in the genetic counseling centers of Isfahan and the ethical issues of clinical consultations

Consanguineous marriage, which is common in many regions in the world,  has absorbed much attention as a causative factor in raising the incidence of genetic diseases. The adverse effects may be attributed to the expression of the genes received from common ancestors and mortality and morbidity of the offspring. Iran has a high rate of consanguineous marriages. In recent years genetic counseling has come to be considered in health care services. This cross-sectional study was conducted in order to determine the prevalence and types of consanguineous marriages in the genetic clinics in Isfahan. We aimed to define the different types of marriages, specific categories of genetic disorders associated with consanguineous marriages, and mode of inheritance in the family tree. We also narratively reviewed the ethical aspects of the issue.The data were collected using a simple questionnaire. A total number of 1535 couples from urban and rural areas formed the study population. The marriages w…

School Notes: December 2017

Crozet Elementary School Principal Gwedette Crummie displays her reading assignments from the students during the Principal's Challenge. Photo: Lisa Martin Crozet Elementary Principal Gwedette Crummie's desk is piled with stacks of books-all suggestions from students for what she might read during this year's Principal's Reading Challenge.

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Angioleiomyoma of the Auricle: An Unusual Tumor on a Rare Location

Cutaneous angioleiomyomas (ALMs) (also known as vascular leiomyomas or angiomyomas) are unusual benign tumors of the skin deriving from the muscle layer of dermal blood vessels. They usually manifest as tender subcutaneous nodules, mostly encountered on the legs of adult women in their fifth or sixth life decade. ALMs rarely develop on the head/neck area, and even more rarely (

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Smear layer-deproteinizing improves bonding of one-step self-etch adhesives to dentin

Publication date: Available online 9 December 2017
Source:Dental Materials
Author(s): Ornnicha Thanatvarakorn, Taweesak Prasansuttiporn, Suppason Thittaweerat, Richard M. Foxton, Shizuko Ichinose, Junji Tagami, Keiichi Hosaka, Masatoshi Nakajima
ObjectivesSmear layer deproteinizing was proved to reduce the organic phase of smear layer covered on dentin surface. It was shown to eliminate hybridized smear layer and nanoleakage expression in resin–dentin bonding interface of two-step self-etch adhesive. This study aimed to investigate those effects on various one-step self-etch adhesives.MethodsFour different one-step self-etch adhesives were used in this study; SE One (SE), Scotchbond™ Universal (SU), BeautiBond Multi (BB), and Bond Force (BF). Flat human dentin surfaces with standardized smear layer were prepared. Smear layer deproteinizing was carried out by the application of 50ppm hypochlorous acid (HOCl) on dentin surface for 15s followed by Accel® (p-toluenesulfinic acid salt) fo…

Effect of tetracalcium phosphate/monetite toothpaste on dentin remineralization and tubule occlusion in vitro

Publication date: Available online 9 December 2017
Source:Dental Materials
Author(s): L. Medvecky, R. Stulajterova, M. Giretova, J. Mincik, M. Vojtko, J. Balko, J. Briancin
ObjectivesTo investigate the tubule occlusion and remineralization potential of a novel toothpaste with active tetracalcium phosphate/monetite mixtures under de/remineralization cycling.MethodsDentin de/remineralization cycling protocol consisted of demineralization in 1% citric acid at pH 4.6 with following remineralization with toothpastes and soaking in artificial saliva. Effectiveness of toothpastes to promote remineralization was evaluated by measurement of microhardness recovery, analysis of surface roughness, thickness of coating and scanning electron microscopy.ResultsThe novel tetracalcium phosphate/monetite dentifrice had comparable remineralization potential as commercial calcium silicate/phosphate (SENSODYNE®) and magnesium aluminum silicate (Colgate®) toothpastes and significantly higher than control …