Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads, Published online: 20 February 2019; doi:10.1038/s41467-019-08691-3

Melanocortin-1 receptor is a palmitoylated protein and variants of the receptor are associated with red hair colour and susceptibility to melanoma. Here, the authors describe a method to enhance the palmitoylation of the receptor, which can inhibit melanomagenesis in mice.

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