Kinetic Resolution and Dynamic Kinetic Resolution of Chromene via Rh‐Catalyzed Asymmetric Hydroarylation

A highly efficient kinetic resolution and dynamic kinetic resolution of chromene is reported for the first time via a Rh‐catalyzed asymmetric hydroarylation pathway. This newly developed approach offers a versatile access of various chiral 2,3‐diaryl‐chromenes containing two vicinal stereogenic centers as well as the recovered chiral flavenes in high yields with excellent ee (s factor is up to 532). Particularly noteworthy is that this strategy can be further extended to the establishment of a dynamic version of kinetic resolution of chromene acetals, in which it allows complete access of chiral isoflavanes and α‐aryl hydrocoumarin successfully.

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