Outcomes of controlled human malaria infection after BCG vaccination

Outcomes of controlled human malaria infection after BCG vaccination

Outcomes of controlled human malaria infection after BCG vaccination, Published online: 20 February 2019; doi:10.1038/s41467-019-08659-3

Immune activation induces long-term alterations of setpoints, impacting responses to subsequent unrelated stimuli. Here the authors show that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activation markers and parasitemia.

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