Suppression of autophagic activity by Rubicon is a signature of aging

Suppression of autophagic activity by Rubicon is a signature of aging

Suppression of autophagic activity by Rubicon is a signature of aging, Published online: 19 February 2019; doi:10.1038/s41467-019-08729-6

Autophagic activity decreases with age via unknown mechanisms. Here the authors show that expression of the negative autophagy regulator Rubicon increases with age, that its genetic ablation improves lifespan and ameliorates a number of age-associated phenotypes in invertebrates and in mouse models.

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