Stereoselective synthesis of sulfur-containing β-enaminonitrile derivatives through electrochemical Csp3–H bond oxidative functionalization of acetonitrile

Stereoselective synthesis of sulfur-containing β-enaminonitrile derivatives through electrochemical Csp³–H bond oxidative functionalization of acetonitrile

Stereoselective synthesis of sulfur-containing β-enaminonitrile derivatives through electrochemical Csp³–H bond oxidative functionalization of acetonitrile, Published online: 19 February 2019; doi:10.1038/s41467-019-08762-5

Direct α-functionalization of acetonitrile, a bulk chemical, is usually limited to its enolate chemistry. Here, the authors show an electro-oxidative C(sp3)–H bond functionalization of acetonitrile with thiols to afford tetrasubstituted olefins with high stereoselectivity.

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