CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

CD8⁺ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

CD8⁺ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens, Published online: 19 February 2019; doi:10.1038/s41467-019-08774-1

Autoreactive T cells are suspected to destroy hypocretin-producing neurons in narcolepsy. Here the authors detect CD8 T cells recognizing narcolepsy-related proteins in healthy individuals and in patients with narcolepsy, and show that the frequency of self-reactive CD8 T cells differs between patients and controls sharing the same HLA-II risk allele.

from A via a.sfakia on Inoreader https://go.nature.com/2IxndJg