Tumor Identification of Less Aggressive or Indolent Lymphoma With Whole-Body 11C-Acetate PET/CT

Purpose The aim of this study was to investigate the diagnostic performance of whole-body [11C]acetate PET/CT in less aggressive or indolent lymphomas, wherein [18F]FDG PET/CT would exhibit limited sensitivity. Methods Between September 2016 and May 2018, we prospectively evaluated 17 patients (9 men, 8 women; mean age [range], 71 [45–87] years) with pathologically proven less aggressive or indolent lymphomas according to Non-Hodgkin's Lymphoma Classification Project, using both [18F]FDG PET/CT and [11C]acetate PET/CT (performed on the same day). Detected nodal lesions were recorded according to the Ann Arbor classification. Extranodal (EN) lesions were also evaluated. We compared whole-body lesion detection between [18F] FDG PET/CT and [11C]acetate PET/CT using the McNemar test. Results In all patients, significantly more nodal and EN lesions were detected using [11C]acetate PET/CT than [18F]FDG PET/CT (nodal: 84 vs 64 regions; P

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