68Ga-PSMA-11 PET/MR Can Be False Positive in Normal Prostatic Tissue

Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein expressed in the cytosol of normal prostate tissue and highly overexpressed on the membrane of prostate cancer, therefore increasingly used to image prostate cancer. We report a case of a 65-year-old man with two focal PSMA-positive areas on a 68Ga-PSMA-11 PET/MR, one corresponding to a prostate carcinoma (Gleason score 4 + 3) and another region without any evidence of malignancy, but with corresponding high PSMA-expression on immunohistochemistry. Received for publication August 14, 2018; revision accepted December 16, 2018. Conflicts of interest and sources of funding: none declared. Correspondence to: Daniela A. Ferraro, MD, Department of Nuclear Medicine, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland. E-mail: Daniela.ferraro@usz.ch. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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