Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine

Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine

Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine, Published online: 20 February 2019; doi:10.1038/s41467-019-08854-2

The RV144 vaccine trial showed reduced risk of HIV-1 acquisition, but mechanisms underlying protection are poorly understood. Here, Fourati et al. assess the transcriptomic profile of blood collected from 223 vaccinees and 40 placebo recipients and identify IRF7 as a mediator of protection.

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