Altered Expression Pattern of CD55 and CD59 on Red Blood Cells in Anemia of Chronic Kidney Disease

Objective: To investigate the expression pattern of CD55 and CD59 on red blood cells (RBCs) in anemic chronic kidney disease (CKD) patients, and factors that might infleunce their expression. Subjects and Methods: Nighty one adult anemic CKD patients and 80 healthy controls (HC) were enrolled. Anemic CKD patients were divided into 3 subgroups based on receiving erythropoietin (EPO) and renal replacement therapies (RRT). Flow cytometric analysis of CD55 and CD59 expression was performed on RBCs from blood samples obtained from CKD patients and HC. Results: CD59 deficiency was significantly higher among CKD patients than HC [n=68 (74.7%)] vs. [n=13 (16.3%)], respectively (p

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