The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope

The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope

The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope, Published online: 04 February 2019; doi:10.1038/s41467-019-08437-1

The TERB1-TERB2-MAJIN complex mediates the attachment of telomeres to the nuclear envelope. Here the authors present the crystal structures of the human TERB1-TERB2 and TERB2-MAJIN subcomplexes and show that Terb2 mutations, which abolish complex formation cause aberrant homologous pairing and disordered synapsis in mouse.

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