SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer

SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer

SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer, Published online: 04 February 2019; doi:10.1038/s41467-019-08380-1

Non-small cell lung cancers with inactivating SMARCA4 mutations are currently undruggable. Here, the authors show that the absence of SMARCA4/2 reduces chromatin accessibility at the CCND1 locus, leading to a subsequent reduction in cyclin D1 expression, which promotes vulnerability of these cancers to CDK4/6 inhibition.

from A via a.sfakia on Inoreader https://go.nature.com/2RD0o6j