Resting state functional connectivity in neurosurgical patients under propofol anesthesia: detectability and variability between patients and between sessions.

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Resting state functional connectivity in neurosurgical patients under propofol anesthesia: detectability and variability between patients and between sessions.

World Neurosurg. 2019 Feb 16;:

Authors: Metwali H, Raemaekers M, Kniese K, Samii A

Abstract
BACKGROUND: Intraoperative assessment of the functional connectivity (FC) provides a new possibility of mapping the eloquent brain region before, during, and after tumor resection. a systematic analysis of the detectability of FC and its variation between subjects and session.
METHODS: the FC was analyzed in 10 pituitary adenoma patients under propofol anesthesia before and after tumor resection. The FC of each session (totally 20 sessions) was correlated to a reference matrix of a group of healthy subjects to evaluate the variations of the overall, interhemispheric and intrahemispheric FC between sessions.
RESULTS: The resting state patterns could be detected during anesthesia (F(1,9)= 112.14; p<0.001)There was a significant effect of session (F(1,9)= 19,401; p=0.002), which included a reduction in resting state from first to the second session. There was no effect of connection type (F(2,8)=1,498; p=0.280), nor was there an interaction between connection type and session (F(2,8),=0.187; p=0.833). The correlation between the observed reduction in resting state activity between the sessions, and the time span between sessions was not significant (r=0.25;p=0.29). The FC of the first session showed a significant correlation to the initial dose of anesthesia (r= 0.7, P= 0.007). However, there was no significant correlation between the total dose of propofol and the FC of the second session (r=1.7; p=0.6).
CONCLUSION: Significant FC could be detected under anesthesia but showed a significant decrease in the second session. To implement the FC intraoperative brain mapping, further studies are required to optimize the depth sedation in order to obtain stable FC between sessions.

PMID: 30780041 [PubMed - as supplied by publisher]

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