Changing temporal context in human temporal lobe promotes memory of distinct episodes.

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Changing temporal context in human temporal lobe promotes memory of distinct episodes.

Nat Commun. 2019 01 14;10(1):203

Authors: El-Kalliny MM, Wittig JH, Sheehan TC, Sreekumar V, Inati SK, Zaghloul KA

Abstract
Memories of experiences that occur around the same time are linked together by a shared temporal context, represented by shared patterns of neural activity. However, shared temporal context may be problematic for selective retrieval of specific memories. Here, we examine intracranial EEG (iEEG) in the human temporal lobe as participants perform a verbal paired associates memory task that requires the encoding of distinct word pairs in memory. We find that the rate of change in patterns of low frequency (3-12 Hz) power distributed across the temporal lobe is significantly related to memory performance. We also find that exogenous electrical stimulation affects how quickly these neural representations of temporal context change with time, which directly affects the ability to successfully form memories for distinct items. Our results indicate that the ability to retrieve distinct episodic memories is related to how quickly neural representations of temporal context change over time during encoding.

PMID: 30643130 [PubMed - indexed for MEDLINE]

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