A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme, Published online: 22 January 2019; doi:10.1038/s41467-018-08145-2

Somatic alterations in the exonuclease domain of DNA polymerase ɛ have been linked to the development of highly mutated cancers. Here, the authors report that a major consequence of the most common cancer-associated Polɛ variant is a dramatically increased DNA polymerase activity.

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