Evaluating the Prognosis of Ischemic Stroke Using Low-Dose Multimodal Computed Tomography Parameters in Hyperacute Phase

Purpose The aim of this study was to evaluate the potential value of low-dose multimodal computed tomography (CT) in predicting prognosis of acute ischemic stroke (AIS) within 6 hours. Methods The admission "one-stop-shop" multimodal CT examination, including noncontrast CT (NCCT), low-dose CT perfusion, and CT angiography (CTA), was performed in patients with symptoms of stroke within 6 hours. Noncontrast CT, CTA source image (CTA-SI), cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), and mean transit time (MTT) maps were studied using Alberta Stroke Program Early CT Score (ASPECTS). The regional leptomeningeal collateral (rLMC) score (0–20) was dichotomized into 2 groups: good (11–20) and poor (0–10) rLMC. Poor functional outcomes were defined by a modified Rankin scale score of 3 to 6. Results One hundred forty-four patients were ultimately selected; 43.8% of them showed poor functional outcomes. They had lower ASPECTSs on NCCT, CTA-SI, CBV, CBF, TTP, and MTT, and poor rLMC was more frequently associated with poor functional outcomes (all P

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