Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages

Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages

Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages, Published online: 15 February 2019; doi:10.1038/s41467-019-08788-9

Shape transformation of proteins created by design in the laboratory is challenging. Here, the authors present a disulfide-mediated approach for the preparation of 16-mer, 24-mer, and 48-mer nanocages from an 8-mer bowl-like protein building block.

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