A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression

A functional subset of CD8⁺ T cells during chronic exhaustion is defined by SIRPα expression

A functional subset of CD8⁺ T cells during chronic exhaustion is defined by SIRPα expression, Published online: 15 February 2019; doi:10.1038/s41467-019-08637-9

SIRPa is most commonly known as a phagocytosis inhibitory receptor expressed by myeloid cells. Here the authors show SIRPa is expressed on a subset of CD8+ T cells with higher proliferative and effector activity during the chronic phase of the immune response to viral infection.

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