Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase

Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase

Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase, Published online: 06 February 2019; doi:10.1038/s41467-019-08529-y

Development of bacterial resistance to an antibiotic can lead to collateral sensitivity to another drug. Here, the authors study collateral sensitivity conferred by mutations in the horizontally acquired β-lactamase CTX-M-15, and identify antibiotic combinations that constrain the evolution of resistance.

from A via a.sfakia on Inoreader https://go.nature.com/2BlaLGC