Structural Gender-Dimorphism and the Biomechanics of the Gluteal Subcutaneous Tissue – Implications for the Pathophysiology of Cellulite

Objective: To investigate gender differences in gluteal subcutaneous architecture and biomechanics to better understand the pathophysiology underlying the mattress-like appearance of cellulite. Materials and Methods: 10 males and 10 female body donors (mean age: 76 ± 16.47 years; range: 36–92 years; mean BMI: 25.27 ± 6.24 kg/m2; range: 16.69-40.76) were used to generate full-thickness longitudinal and transverse gluteal slices. In the superficial and deep fatty layers, fat lobule number, height, and width were investigated. The force needed to cause septal breakage between the dermis and superficial fascia was measured using biomechanical testing. Results: Increased age was significantly related to decreased dermal thickness, independent of gender (OR 0.997, 95% CI [0.996 – 0.998], p

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