Barcode-free next-generation sequencing error validation for ultra-rare variant detection

Barcode-free next-generation sequencing error validation for ultra-rare variant detection

Barcode-free next-generation sequencing error validation for ultra-rare variant detection, Published online: 28 February 2019; doi:10.1038/s41467-019-08941-4

Next generation sequencing has difficulty in detecting rare-frequency variants due to high sequencing errors. Here the authors present a barcode-free error validation method that physically extracts erroneous reads to identify true variants.

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