Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments

Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments

Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments, Published online: 31 January 2019; doi:10.1038/s41467-019-08465-x

For mesenchymal stem cells (MSCs), matrix remodeling is associated with enhanced osteogenic differentiation. Here authors find that MSCs in viscoelastic hydrogels exhibit volume expansion during cell spreading, and greater volume expansion is associated with enhanced osteogenesis.

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