Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues

Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues

Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues, Published online: 23 January 2019; doi:10.1038/s41467-019-08296-w

The DNA ligase of African swine fever virus is one of the most error-prone ligases identified to date, but underlying molecular details are lacking. Here, Chen et al. report four AsfvLIG:DNA structures and identify a unique N-terminal domain and four unique active site residues that are crucial for its catalytic efficiency.

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