Exploring the landscape of focal amplifications in cancer using AmpliconArchitect

Exploring the landscape of focal amplifications in cancer using AmpliconArchitect

Exploring the landscape of focal amplifications in cancer using AmpliconArchitect, Published online: 23 January 2019; doi:10.1038/s41467-018-08200-y

Focal amplifications are prevalent in many cancer genomes. Here, the authors present AmpliconArchitect (AA), a computational tool for reconstructing their architecture, and reveal an extrachromosomal origin for focal amplifications, including hybrid human-virus elements in HPV-mediated cancers.

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