Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

In living cells, redox chains rely on nanoconfinement – using tiny enclosures such as the mitochondrial matrix or chloroplast stroma to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, NADP+ and NADPH are cycled rapidly between ferredoxin‐NADP+ reductase and a second enzyme – pairs being juxtaposed within the 5‐100 nm‐scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support can drive and exploit a potentially unlimited number of enzyme‐catalyzed reactions.

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