CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage, Published online: 03 January 2019; doi:10.1038/s41467-018-07971-8

Gene editing strategies are typically designed to correct mutant genes, but most neurodegenerative diseases are sporadic. Here the authors describe a strategy to selectively edit the C-terminus of APP and attenuate amyloid-β production, while upregulating neuroprotective α-cleavage.

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