Catalytic enantioselective construction of axial chirality in 1,3-disubstituted allenes

Catalytic enantioselective construction of axial chirality in 1,3-disubstituted allenes

Catalytic enantioselective construction of axial chirality in 1,3-disubstituted allenes, Published online: 31 January 2019; doi:10.1038/s41467-018-07908-1

Highly enantioselective synthesis of allenes has been relying, so far, on the steric hindrance of substrates. Here the authors achieve excellent stereocontrol in the synthesis of chiral allenes with a palladium-DTBM-SEGPHOS catalytic system in a non-substrate-dependent manner.

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