A scalable total synthesis of Et‐743 and lurbinectedin

An efficient and scalable approach for total synthesis of Et‐743 and lubinectedin (about 1.6% overall yield in 26 total steps from Cbz‐protected (S)‐tyrosine) is described, and features the use of a common advanced intermediate to create the right and left parts of these antitumor drugs, and a light‐mediated remote C‐H bond activation to assemble a benzo[1,3]dioxole‐embodied intermediate.

from A via a.sfakia on Inoreader http://bit.ly/2sS7ytu