SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4, Published online: 19 December 2018; doi:10.1038/s41467-018-07620-0

SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects specifically against MLL-rearranged AML cells.

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