Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity

Metabolic heterogeneity underlies reciprocal fates of T_H17 cell stemness and plasticity

Metabolic heterogeneity underlies reciprocal fates of T_H17 cell stemness and plasticity, Published online: 19 December 2018; doi:10.1038/s41586-018-0806-7

Phenotypically, transcriptionally and metabolically diverse subsets of TH17 cells develop in a chronic autoimmune disease: one subset has inferred stemness features and low anabolic metabolism, while a reciprocal subset has higher metabolic activity that supports transdifferentiation into TH1 cells.

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