Richter Syndrome Presenting With Colon Localization

A 75-year-old man, who had been diagnosed with small lymphocytic lymphoma with cervical localization, underwent 18F-FDG PET/CT with iodinated contrast medium due to the appearance of cervical swelling suspected of illness relapse. PET/CT revealed intense 18F-FDG uptake in multiple cervical and subdiaphragmatic lymph nodes and in the left parotid. Moreover, diffuse uptake and wall thickening of the colon were evident; endoscopy with biopsy revealed a diffuse large B-cell lymphoma. Transformation into a more aggressive lymphoma occurs in 2% to 8% of small lymphocytic lymphoma, the so-called Richter syndrome. Extranodal localization in the sigmoid colon is an extremely rare site for transformed lymphoma. Received for publication April 24, 2018; revision accepted October 13, 2018. Conflict of interest and sources of funding: none declared. Correspondence to: Mariadea Lavalle, MD, Nuclear Medicine Unit, Ente Ecclesiastico Ospedale Generale Regionale "F. Miulli," S.P. 127 Acquaviva/Santeramo Km. 4100, 70021 Acquaviva delle Fonti, Bari, Italy. E-mail: m.lavalle@miulli.it. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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