A Mixed Variant of Castleman Disease Detected by Somatostatin Receptor Scintigraphy with 99mTc-HYNIC-TOC and 18F-FDG PET/CT

A 50-year-old woman was found with a hypervascular abdominal mass in the right lower quadrant in contrast-enhanced CT. Somatostatin receptor scintigraphy with 99mTc-HYNIC-TOC showed positivity of the abdominal mass and detected additional lesion with moderate increased radioactivity in the right axilla. In 18F-FDG PET/CT, both of the lesions were FDG-avid. A hypermetabolic node in the right supraclavicular fossa was also noted. The histopathological examination of the abdominal mass after surgical resection revealed Castleman disease, a mixed hyaline vascular and plasma cell variant. The right axillary and supraclavicular lesions were considered involvement of Castleman disease. Received for publication September 23, 2018; revision accepted October 22, 2018. Conflicts of interest and sources of funding: This work is supported by the CAMS Initiative for Innovative Medicine (CAMS-I2M, 2017-I2M-3-001). None declared to all authors. Correspondence to: Yaping Luo, MD, Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital; Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine Wangfujing, Dongcheng District, Beijing 100730, People's Republic of China. E-mail: luoyaping@live.com. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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