Novel Therapeutic Strategy for Pharyngoesophageal Stricture following Total Laryngectomy.

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Novel Therapeutic Strategy for Pharyngoesophageal Stricture following Total Laryngectomy.

Otolaryngol Head Neck Surg. 2018 Dec 11;:194599818815164

Authors: Wu PI, Szczesniak MM, Fox DA, Maclean J, Blom ED, Cook IJ

Abstract
Current therapeutic strategies for pharyngoesophageal stricture, while effective in the short term, are protracted and costly in the longer term. Conceptually, if a stricture can be dilated with minimal tissue injuries, the rate of fibrosis and the resultant stricture recurrence could be reduced. We evaluated a prototype computer-controlled syringe pump device programmed to distend a commercially available balloon dilator at variable rate, asserting incremental lumen distension pressures tailored to the resistive force encountered within the stricture. We completed 17 graded dilatation procedures among 4 total laryngectomy patients. All patients had a short-term response (1 month), with a mean decrement (improvement) in Sydney Swallow Questionnaire score of 448 (total score range, 0-1700; normal <234). The overall procedural tolerability and safety were encouraging; the only complication was the displacement of the voice prosthesis during 1 dilatation. From a technical viewpoint, the main challenge was to maintain the balloon in position during dilatation.

PMID: 30526296 [PubMed - as supplied by publisher]

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