Integrin CD11b activation drives anti-tumor innate immunity

Integrin CD11b activation drives anti-tumor innate immunity

Integrin CD11b activation drives anti-tumor innate immunity, Published online: 19 December 2018; doi:10.1038/s41467-018-07387-4

Recruitment of myeloid cells can be regulated by integrin CD11b. Here the authors show that in the tumor microenvironment, CD11b is not essential for recruitment of myeloid cells but rather induces macrophage anti-tumorigenic polarization via stimulating let7a and NFκB signaling and that pharmacological activation of CD11b enhances survival in mouse models of cancer.

from A via a.sfakia on Inoreader https://ift.tt/2BwfzID