Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis, Published online: 12 December 2018; doi:10.1038/s41467-018-07698-6

Activation of PI3K plays a role in pulmonary inflammation. Here, the authors develop a drug inhibitor of PI3K, and show that it inhibits lung inflammation and damage in mouse models of asthma and lung fibrosis.

from A via a.sfakia on Inoreader https://ift.tt/2Eq3BUJ