Response to letter to the editor of Carcinogenesis by Pira et al. , 2017

We conducted a cross-sectional study of 43 workers exposed to formaldehyde in the workplace and 51 unexposed controls (1) to examine the biological plausibility that formaldehyde causes myeloid leukemia (2). In our article entitled 'Chromosome-wide aneuploidy study of cultured circulating myeloid progenitor cells from workers occupationally exposed to formaldehyde' published in 2015 in Carcinogenesis (3), we reported that aneuploidy rates were increased for multiple chromosomes in 29 formaldehyde-exposed workers compared to 23 controls (3). Of particular interest was our a priori hypothesized increase in monosomy 7, the most frequent autosomal monosomy in acute myeloid leukemia (AML) (4) that was elevated in an initial report from a smaller subgroup of this study (1). A letter to the editor by Pira et al. (5) has raised a number of concerns about our article. We welcome the opportunity to respond and further clarify our study's findings.

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