Studying flies and mice, Jasper and colleagues demonstrate that repeated regenerative episodes result in the loss of tissue stem cells (SCs) due to the transient activation of the growth regulator mTORC1 during SC activation. Pharmacological inhibition of mTORC1 can prevent this loss and limit the age-related decline in SC numbers.
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Πέμπτη 7 Δεκεμβρίου 2017
mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance
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