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GSE106605 Covalent inhibitor of the Rho family inhibits the migration of breast cancer cells

Contributors : Zhongya Sun ; Hao Zhang ; Liping Liao ; Cheng LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSmall GTPase proteins usually serve as molecular switches in various biological process, such as the proliferation, survival, and migration of cells. Mutations or aberrant activations of small GTPase proteins, such as Ras, are frequently observed in various kinds of cancers. Drug discovery efforts that target the Ras family proteins are making breakthroughs, while the discovery of efficient inhibitors that target the Rho family proteins is still stagnant. Protein members from the Rho family, such as RhoA and Cdc42, are key regulators of the migration and invasion of cancer cells. Thus inhibitors of the Rho family proteins are promising to be...

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