Glioblastoma Stem Cells and Their Microenvironment.

Authors: Sattiraju A, Sai KKS, Mintz A Abstract Glioblastoma (GBM) is the most common primary malignant astrocytoma associated with a poor patient survival. Apart from arising de novo, GBMs also occur due to progression of slower growing grade III astrocytomas. GBM is characterized by extensive hypoxia, angiogenesis, proliferation and invasion. Standard treatment options such as surgical resection, radiation therapy and chemotherapy have increased median patient survival to 14.6 months in adults but recurrent disease arising from treatment resistant cancer cells often results in patient mortality. These treatment resistant cancer cells have been found to exhibit stem cell like properties. Strategies to identify or target these Glioblastoma Stem Cells (GSC) have proven to be unsucc...

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://ift.tt/2jpxZm0
via IFTTT