Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor

Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor

Nature Immunology, Published online: 30 October 2017; doi:10.1038/ni.3868

The tumor microenvironment represents a stressful cellular environment. Zou and colleagues show that T_reg cells in tumors have heightened sensitivity to apoptosis, but unexpectedly this increases their suppressive potency.

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