Curing hepatitis C virus (HCV) after organ transplantation: Increased risk of rejection following HCV elimination

Hepatitis C virus (HCV) infection in the post-transplantation setting adversely affects survival of liver recipients and other solid organ recipients.^1,2 Therefore, curing HCV infection is highly desirable after organ transplantation. With the availability of direct-acting antivirals (DAA), HCV cure is nearly universally possible. Could there be any downsides to curing HCV? We describe two patients developing acute liver rejection following the cure of HCV. These cases highlight a need for vigilance in monitoring for rejection after cure of HCV.

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