Personalized Management of Cardiovascular Disorders

Personalized management of cardiovascular disorders (CVDs), also referred to as personalized or precision cardiology in accordance with general principles of personalized medicine, is the selection of best treatment for an individual patient. It involves the integration of various 'omics' technologies such as genomics and proteomics as well as other new technologies such as nanobiotechnology. Molecular diagnostics and biomarkers are important for linking diagnosis with therapy and monitoring of therapy. Because CVDs involve perturbations of large complex biological networks, a systems biology approach to CVD risk stratification may be used for improving risk-estimating algorithms and modeling of personalized benefit-of-treatment may be helpful for guiding choice of intervention. Bioinformatic tools are helpful in analyzing and integration of large amount of data from various sources. Personalized therapy is considered during drug development including methods of targeted drug delivery and clinical trials. Individualized recommendations consider multiple factors for patients' risk of heart disease - genetic as well as epigenetic. Examples of personalized treatment of chronic myocardial ischemia, heart failure, and hypertension. Similar approaches can be used for management of atrial fibrillation, and hypercholesterolemia as well as use of anticoagulants. Personalized management includes pharmacotherapy, surgery, life style modification and combinations thereof. Further progress in understanding of the pathomechanism of complex cardiovascular diseases and identification of causative factors at the individual patient level will provide opportunities for development of personalized cardiology. Application of principles of personalized medicine will improve the care of the patients with CVDs.


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