Effects of Mucuna pruriens on Free Fatty Acid Levels and Histopathological Changes in the Brains of Rats Fed a High Fructose Diet

Objective: To investigate free fatty acid levels and histopathologic changes in the brain of rats fed a high fructose diet and to evaluate the effects of Mucuna pruriens, known to have antidiabetic activity, on these changes. Materials and Methods: The study comprised of 28 mature female Wistar rats. The rats were divided into four groups, each included 7 rats. Group 1: control; Group 2: fed a high fructose diet (HFrD), Group 3: fed normal rat chow and Mucuna pruriens, and Group 4: fed a high fructose diet and Mucuna pruriens for 6 weeks. At the end of 6 weeks, the rats were decapitated, blood and brain tissues were obtained. Serum glucose and triglyceride levels were measured. Free fatty acid (FFA) levels were measured in one cerebral hemisphere of each rat and histopathological changes in the other. The Mann Whitney-U test was used to compare quantitative continuous data between two independent groups, and the Kruskal Wallis test was used to compare quantitative continuous data between more than two independent groups. Results: Arachidonic acid and docosahexaenoic acid levels were significantly higher in Group 2 than Group 1 (p

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